The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes
Abstract
Aim: To provide an update of the review by Taylor (Journal of Clinical Periodontology, 2013, 40, S113) regarding the scientific evidence of the biological association between periodontitis and diabetes. Methods: Literature searches were performed using Me SH terms, keywords and title words and were published between 2012 and November 2016. All publications were screened for their relevance. The data from the articles were extracted and summarized in tables and a narrative review. Results: Small‐scale molecular periodontal microbiome studies indicate a possible association between altered glucose metabolism in pre‐diabetes and diabetes and changes in the periodontal microbiome, with no evidence for casual relationships. Clinical and animal studies found elevated gingival levels of IL 1‐β, TNF‐α, IL‐6, RANKL/OPG and oxygen metabolites in poorly controlled diabetes. In addition, individuals with diabetes and periodontitis exhibit high levels of circulating TNF‐α, CRP and mediators of oxidative stress, and successful periodontal treatment reduces their levels. Conclusions: The elevated pro‐inflammatory factors in the gingiva of patients with poorly controlled diabetes suggest a biological pathway that may aggravate periodontitis. Some evidence suggests that the systemic inflammatory burden in periodontitis has the potential to affect diabetes control, but no studies addressed the impact of successful periodontal therapy on the pathophysiological mechanisms involved in systemic complications of diabetes.
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Cites
Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062
Effect of Periodontal Treatment on Glycemic Control of Diabetic Patients
Teeuw, W. J., Gerdes, V. E. A., & Loos, B. G. (2010) · Diabetes Care · doi:10.2337/dc09-1378 · Cited by 522
Chapple, I. L. C., Genco, R., & working group 2 of the joint EFP/AAP workshop (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12077 · Cited by 446
A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes
Taylor, J. J., Preshaw, P. M., & Lalla, E. (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12059 · Cited by 425
Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice
Lalla, E., Lamster, I. B., Feit, M., Huang, L., Spessot, A., Qu, W., Kislinger, T., Lu, Y., Stern, D. M., & Schmidt, A. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8942 · Cited by 375
Diabetes mellitus related bone metabolism and periodontal disease
Wu, Y.-Y., Xiao, E., & Graves, D. T. (2015) · International Journal of Oral Science · doi:10.1038/ijos.2015.2 · Cited by 310
Treatment of periodontal disease for glycaemic control in people with diabetes
Simpson, T. C., Needleman, I., Wild, S. H., Moles, D. R., & Mills, E. J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004714.pub2 · Cited by 283
Molecular mechanisms of insulin resistance and the role of the adipocyte
Hotamisligil, G. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801497 · Cited by 269
Subgingival biodiversity in subjects with uncontrolled type‐2 diabetes and chronic periodontitis
Casarin, R. C. V., Barbagallo, A., Meulman, T., Santos, V. R., Sallum, E. A., Nociti, F. H., Duarte, P. M., Casati, M. Z., & Gonçalves, R. B. (2013) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2012.01498.x · Cited by 256 · cited 2×
“Recent studies that explored the possible association between the compositions of the periodontal flora in patients with diabetes using 16S rRNA Sequencing (Casarin et al., 2013; Zhou et al., 2013) found evidence which may indicate a difference in microbial composition in patients with diabetes mellitus (DM).”
BackgroundEngebretson, S., & Kocher, T. (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12084 · Cited by 236
Cited by
Sanz, M., Ceriello, A., Buysschaert, M., Chapple, I., Demmer, R. T., Graziani, F., Herrera, D., Jepsen, S., Lione, L., Madianos, P., et al. (2018) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12808 · Cited by 738
Self-citationJepsen, S., Caton, J. G., Albandar, J. M., Bissada, N. F., Bouchard, P., Cortellini, P., Demirel, K., de Sanctis, M., Ercoli, C., Fan, J., et al. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0733 · Cited by 602
Jepsen, S., Caton, J. G., Albandar, J. M., Bissada, N. F., Bouchard, P., Cortellini, P., Demirel, K., de Sanctis, M., Ercoli, C., Fan, J., et al. (2018) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12951 · Cited by 566
Sanz, M., Ceriello, A., Buysschaert, M., Chapple, I., Demmer, R. T., Graziani, F., Herrera, D., Jepsen, S., Lione, L., Madianos, P., et al. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.12.001 · Cited by 336
Self-citationAlbandar, J. M., Susin, C., & Hughes, F. J. (2018) · Journal of Periodontology · doi:10.1002/jper.16-0480 · Cited by 253
Metadata
- Authors
- Polak, D., & Shapira, L.
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2017-12-26
- Volume
- 45
- Issue
- 2
- Pages
- 150-166
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W2749653140
- Cited by
- 396
- References
- 62
- FWCI
- 29.00
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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