The DOI matches its Crossref record; 165 of the 166 references it cites were found in a registry or an index.
Peri‐implantitis
Open accessAbstract
Objectives: This narrative review provides an evidence‐based overview on peri‐implantitis for the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Methods: A literature review was conducted addressing the following topics: 1) definition of peri‐implantitis; 2) conversion from peri‐implant mucositis to peri‐implantitis, 3) onset and pattern of disease progression, 4) characteristics of peri‐implantitis, 5) risk factors/indicators for peri‐implantitis, and 6) progressive crestal bone loss in the absence of soft tissue inflammation. Conclusions: Peri‐implantitis is a pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri‐implant connective tissue and progressive loss of supporting bone. The histopathologic and clinical conditions leading to the conversion from peri‐implant mucositis to peri‐implantitis are not completely understood. The onset of peri‐implantitis may occur early during follow‐up and the disease progresses in a non‐linear and accelerating pattern. Peri‐implantitis sites exhibit clinical signs of inflammation and increased probing depths compared to baseline measurements. At the histologic level, compared to periodontitis sites, peri‐implantitis sites often have larger inflammatory lesions. Surgical entry at peri‐implantitis sites often reveals a circumferential pattern of bone loss. There is strong evidence that there is an increased risk of developing peri‐implantitis in patients who have a history of chronic periodontitis, poor plaque control skills, and no regular maintenance care after implant therapy. Data identifying “smoking” and “diabetes” as potential risk factors/indicators for peri‐implantitis are inconclusive. There is some limited evidence linking peri‐implantitis to other factors such as: post‐restorative presence of submucosal cement, lack of peri‐implant keratinized mucosa and positioning of implants that make it difficult to perform oral hygiene and maintenance. Evidence suggests that progressive crestal bone loss around implants in the absence of clinical signs of soft tissue inflammation is a rare event.
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“Early identification and intervention at the mucositis stage is critical [12, 13]”
From Confidence of primary care dental practitioners in the assessment, referral and maintenance of dental implants: a cross-sectional survey in Yorkshire (2026) · cites this paper as [12]
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Citations
Cites
Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216
Global Burden of Severe Periodontitis in 1990-2010: A Systematic Review and Meta-regression
Kassebaum, N. J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C. J. L., & Marcenes, W. (2014) · Journal of Dental Research · doi:10.1177/0022034514552491 · Cited by 2,209
Peri‐implant diseases: Consensus Report of the Sixth European Workshop on Periodontology
Lindhe, J., Meyle, J., & on behalf of Group D of the European Workshop on Periodontology (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01283.x · Cited by 1,524
Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 – 2012
Eke, P., Dye, B., Wei, L., Slade, G., Thornton-Evans, G., Borgnakke, W., Taylor, G., Page, R., Beck, J., & Genco, R. (2015) · The Journal of Periodontology · doi:10.1902/jop.2015.140520 · Cited by 1,442
Risk factors for periodontal disease
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Smoking‐Attributable Periodontitis in the United States: Findings From NHANES III
Tomar, S. L., & Asma, S. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.5.743 · Cited by 1,002
Lang, N. P., Berglundh, T., & on Behalf of Working Group 4 of the Seventh European Workshop on Periodontology (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01674.x · Cited by 930
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Lindquist, L. W., Carlsson, G. E., & Jemt, T. (1996) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1996.070405.x · Cited by 700
Experimental breakdown of peri‐implant and periodontal tissues. A study in the beagle dog
Lindhe, J., Berglundh, T., Ericsson, I., Liljenberg, B., & Marinello, C. P. (1992) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1992.030102.x · Cited by 667
Research works printed but not linked: 1
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Villarreal-Arizpe, K., Wang, I.-C., Pitchumani, P. K., Durán-Garnica, O., & Chan, H. (2026) · International Journal of Implant Dentistry · doi:10.1186/s40729-026-00675-5
Metadata
- Authors
- Schwarz, F., Derks, J., Monje, A., & Wang, H.
- Affiliations
- Goethe University Frankfurt (DE)
- University of Gothenburg (SE)
- University of Bern (CH)
- University of Michigan (US)
- Corresponding author
- Schwarz, Frank
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2018-06
- Volume
- 45
- Issue
- S20
- Pages
- S246-S266
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W4211043384
- Cited by
- 1,066
- References
- 166
- Citations by year
- 2026: 130 · 2025: 139 · 2024: 186 · 2023: 179 · 2022: 159 · 2021: 116 · 2020: 108 · 2019: 39 · 2018: 7
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal Of Clinical Periodontology (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- Oral Reconstruction Foundation
- Topics
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- peri-implantitis, peri-implant mucositis, dental implants, marginal bone loss, disease progression, risk factors, chronic periodontitis, plaque control, smoking, diabetes mellitus, keratinized mucosa, probing depth, histopathology, peri-implant maintenance
- MeSH terms
- Dental Plaque, Humans, Oral Hygiene, Stomatitis, Dental Implants, Peri-Implantitis
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