Antibiotic resistance in acne: changes, consequences and concerns

Karadag, A.S.; Aslan Kayıran, M.; Wu, C.‐Y.; Chen, W.; Parish, L.C.

doi:10.1111/jdv.16686

Cited by 91Acne and Rosacea Treatments and EffectsAntibiotic Use and ResistanceAntibiotic Resistance in Bacteria

Antibiotic resistance in acne: changes, consequences and concerns

Karadag, A.S., Aslan Kayıran, M., Wu, C.‐Y., Chen, W., Parish, L.C.·2021·Journal of the European Academy of Dermatology and Venereology

DOI 10.1111/jdv.16686

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Abstract

Antibiotic resistance in acne was first observed in the 1970s and has been a major concern in dermatology since the 1980s. The resistance rates and types of antimicrobials have subsequently shown great variations in regions and countries. Illustrative of this is the resistance to topical erythromycin and clindamycin which continues to be a problem worldwide, while resistance to systemic treatment with tetracyclines has remained low during the past decade. The resistance for the newer macrolides like azithromycin and clarithromycin has been increasing. The results of antibiotic resistance may include treatment failure of acne, disturbance of skin microbiota, induction of opportunistic pathogens locally and systemically, and dissemination of resistant strains to both healthcare personnel and the general population. The ensuing complications, such as aggravated opportunistic infections caused by Propionibacterium acnes and the emergence of multiresistant superbugs, have not yet been confirmed.

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To prevent the development of resistance, antibiotic monotherapy is not recommended.
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Authors: Karadag, A. S., Aslan Kayıran, M., Wu, C. ‐., Chen, W., & Parish, L. C.
Affiliations: Department of Dermatology and Venereology School of Medicine Istanbul Medeniyet University, Goztepe Research and Training Hospital Istanbul Turkey
Kaohsiung Medical University (TW)
Ministry of Health and Welfare (TW)
Thomas Jefferson University (US)
ORCID: Karadag, A.S.
Aslan Kayıran, M.
Wu, C.‐Y.
Chen, W.
Parish, L.C.
Venue: Journal of the European Academy of Dermatology and Venereology
Publisher: Wiley
Published: 2020-06-26
Volume: 35
Issue: 1
Pages: 73-78
ISSN: 0926-9959 (ISSN-L)
1468-3083
DOI: 10.1111/jdv.16686
OpenAlex: W3031272540
Cited by: 91
References: 77
Citations by year: 2026: 10 · 2025: 18 · 2024: 15 · 2023: 17 · 2022: 12 · 2021: 12 · 2020: 7
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of the European Academy of Dermatology and Venereology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords: antibiotic resistance, acne, Propionibacterium acnes, topical erythromycin, topical clindamycin, tetracycline, macrolides, azithromycin, clarithromycin, skin microbiome, opportunistic infections, multidrug resistance, treatment failure
MeSH terms: Acne Vulgaris, Anti-Bacterial Agents, Clindamycin, Drug Resistance, Microbial, Humans, Microbial Sensitivity Tests, Propionibacterium acnes, Drug Resistance, Bacterial

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Antibiotic resistance in acne: changes, consequences and concerns

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