The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Prebiotic inulin‐type fructans and galacto‐oligosaccharides: definition, specificity, function, and application in gastrointestinal disorders
Open accessAbstract
Prebiotics are non‐digestible selectively fermented dietary fibers that specifically promote the growth of one or more bacterial genera in the gastrointestinal tract and thus provide health benefit to the host. The two most investigated prebiotics being the inulin‐type fructans and galacto‐oligosaccharides. Prebiotic specificity is mediated through species‐specific gene clusters within saccharolytic bacteria controlled by signaling sensors for various substrates. Prebiotic health benefits are attributed to immune regulation and bacterial metabolite production. In humans, prebiotic supplementation leads to increased growth of specific gut microbiota (e.g., bifidobacteria), immune modulation, and depending on the bacterial augmentation, short‐chain fatty acid production. Irritable bowel syndrome and Crohn's disease are gastrointestinal disorders associated with reductions in some gut bacteria and greater mucosal inflammation. Prebiotic supplementation studies have shown some promise at low doses for modulation of the gut bacteria and reduction of symptoms in IBS; however, larger doses may have neutral or negative impact on symptoms. Studies in Crohn's disease have not shown benefit to bacterial modulation or inflammatory response with prebiotic supplementation. Dietary restriction of fermentable carbohydrates (low FODMAP diet), which restricts some naturally occurring prebiotics from the diet, has shown efficacy in improving symptoms in irritable bowel syndrome, but it lowers the numbers of some key gut microbiota. Further research is required on the effect of prebiotics in gastrointestinal disorders and, in particular, on their use in conjunction with the low FODMAP diet.
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Immunological properties of inulin-type fructans
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Cited by
The gut microbiota at the intersection of diet and human health
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Dietary fibre in gastrointestinal health and disease
Gill, S. K., Rossi, M., Bajka, B., & Whelan, K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00375-4 · Cited by 979
Self-citationThe effects of vegetarian and vegan diets on gut microbiota
Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N. D., & Kahleova, H. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00047 · Cited by 713
Soluble Dietary Fiber, One of the Most Important Nutrients for the Gut Microbiota
Guan, Z.-W., Yu, E.-Z., & Feng, Q. (2021) · Molecules · doi:10.3390/molecules26226802 · Cited by 336
Healey, G., Murphy, R., Butts, C., Brough, L., Whelan, K., & Coad, J. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114517003440 · Cited by 267
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Metadata
- Authors
- Wilson, B., & Whelan, K.
- Venue
- Journal of Gastroenterology and Hepatology
- Publisher
- Wiley
- Published
- 2017-02-28
- Volume
- 32
- Issue
- S1
- Pages
- 64-68
- ISSN
- 0815-9319 (ISSN-L)
- 1440-1746
- OpenAlex
- W2597147518
- Cited by
- 321
- References
- 9
- FWCI
- 22.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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