Intestinal Microbiota in Healthy Adults: Temporal Analysis Reveals Individual and Common Core and Relation to Intestinal Symptoms
Open accessAbstract
BACKGROUND: While our knowledge of the intestinal microbiota during disease is accumulating, basic information of the microbiota in healthy subjects is still scarce. The aim of this study was to characterize the intestinal microbiota of healthy adults and specifically address its temporal stability, core microbiota and relation with intestinal symptoms. We carried out a longitudinal study by following a set of 15 healthy Finnish subjects for seven weeks and regularly assessed their intestinal bacteria and archaea with the Human Intestinal Tract (HIT) Chip, a phylogenetic microarray, in conjunction with qPCR analyses. The health perception and occurrence of intestinal symptoms was recorded by questionnaire at each sampling point. PRINCIPAL FINDINGS: A high overall temporal stability of the microbiota was observed. Five subjects showed transient microbiota destabilization, which correlated not only with the intake of antibiotics but also with overseas travelling and temporary illness, expanding the hitherto known factors affecting the intestinal microbiota. We identified significant correlations between the microbiota and common intestinal symptoms, including abdominal pain and bloating. The most striking finding was the inverse correlation between Bifidobacteria and abdominal pain: subjects who experienced pain had over five-fold less Bifidobacteria compared to those without pain. Finally, a novel computational approach was used to define the common core microbiota, highlighting the role of the analysis depth in finding the phylogenetic core and estimating its size. The in-depth analysis suggested that we share a substantial number of our intestinal phylotypes but as they represent highly variable proportions of the total community, many of them often remain undetected. CONCLUSIONS/SIGNIFICANCE: A global and high-resolution microbiota analysis was carried out to determine the temporal stability, the associations with intestinal symptoms, and the individual and common core microbiota in healthy adults. The findings provide new approaches to define intestinal health and to further characterize the microbial communities inhabiting the human gut.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A strong association was evident between protein intake and Bacteroides, and in particular Ruminococcaceae and Lachnospiraceae, in explaining community diversity.
“A strong association was evident between protein intake and Bacteroides and, in particular, Ruminococcaceae and Lachnospiraceae, two of the most abundant families in human gut environments [188], in explaining community diversity.”
From The athletic gut microbiota (2020) · cites this paper as [188]
Higher Bifidobacterium abundance was inversely associated with abdominal pain and intestinal discomfort in a longitudinal study in healthy individuals.
“These correlations are in agreement with previous findings from a longitudinal study in healthy individuals, where higher Bifidobacterium abundance was inversely associated with abdominal pain and intestinal discomfort.”
From Adaptation to tolerate high doses of arabinoxylan is associated with fecal levels of <i>Bifidobacterium longum</i> (2024) · cites this paper as [59]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Mixed-Effects Models in Sand S-PLUS
Pinheiro, J. C., & Bates, D. M. (2000) · Statistics and Computing · doi:10.1007/978-1-4419-0318-1 · Cited by 11,187 · see citing works
Mixed-Effects Models in S and S-PLUS
(2001) · Technometrics · doi:10.1198/tech.2001.s574 · Cited by 9,278 · see citing works
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,185 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Nonparametric Statistical Methods
(1999) · Technometrics · doi:10.1080/00401706.1999.10485954 · Cited by 6,117 · see citing works
A Direct Approach to False Discovery Rates
Storey, J. D. (2002) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00346 · Cited by 5,603 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952 · see citing works
The rand 36‐item health survey 1.0
Hays, R. D., Sherbourne, C. D., & Mazel, R. M. (1993) · Health Economics · doi:10.1002/hec.4730020305 · Cited by 2,893 · see citing works
Nonparametric Statistical Methods.
Knott, M. J., Hollander, M., & Wolfe, D. A. (1974) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2344557 · Cited by 2,687 · see citing works
Succession of microbial consortia in the developing infant gut microbiome
Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540 · see citing works
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361 · see citing works
Prebiotic effects: metabolic and health benefits
Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,098 · see citing works
Nadkarni, M. A., Martin, F. E., Jacques, N. A., & Hunter, N. (2002) · Microbiology · doi:10.1099/00221287-148-1-257 · Cited by 1,931 · see citing works
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works
The RAND-36 measure of health-related quality of life
Hays, R. D., & Morales, L. S. (2001) · Annals of Medicine · doi:10.3109/07853890109002089 · Cited by 1,460 · see citing works
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works
Low counts of Faecalibacterium prausnitzii in colitis microbiota
Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20903 · Cited by 1,275 · see citing works
Long-term ecological impacts of antibiotic administration on the human intestinal microbiota
Jernberg, C., Löfmark, S., Edlund, C., & Jansson, J. K. (2007) · The ISME Journal · doi:10.1038/ismej.2007.3 · Cited by 1,134 · see citing works
Willing, B. P., Dicksved, J., Halfvarson, J., Andersson, A. F., Lucio, M., Zheng, Z., Järnerot, G., Tysk, C., Jansson, J. K., & Engstrand, L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.049 · Cited by 1,032 · see citing works
Rinttilä, T., Kassinen, A., Malinen, E., Krogius-Kurikka, L., & Palva, A. (2004) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2004.02409.x · Cited by 1,018 · see citing works
Self-citationKassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002 · see citing works
Self-citationMicrobial community profiling for human microbiome projects: Tools, techniques, and challengesPreprint
Hamady, M., & Knight, R. D. (2009) · Genome Research · doi:10.1101/gr.085464.108 · Cited by 998 · see citing works
Towards the human intestinal microbiota phylogenetic core
Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J., Ugarte, E., Muñoz‐Tamayo, R., Paslier, D. L. E., Nalin, R., et al. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01982.x · Cited by 927 · see citing works
Claesson, M. J., O’Sullivan, Ó., Wang, Q., Nikkilä, J., Marchesi, J. R., Smidt, H., de Vos, W. M., Ross, R. P., & O’Toole, P. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006669 · Cited by 880 · see citing works
Self-citationBecker, R. A., Chambers, J. M., & Wilks, A. R. (1989) · Biometrics · doi:10.2307/2531523 · Cited by 826 · see citing works
Louis, P., Young, P., Holtrop, G., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02066.x · Cited by 783 · see citing works
The impact of irritable bowel syndrome on health-related quality of life
Gralnek, I. M., Hays, R. D., Kilbourne, A., Naliboff, B., & Mayer, E. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.16484 · Cited by 781 · see citing works
Enrichment or depletion of a GO category within a class of genes: which test?
Rivals, I., Personnaz, L., Taing, L., & Potier, M. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl633 · Cited by 722 · see citing works
Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works
Self-citationHigh-throughput diversity and functionality analysis of the gastrointestinal tract microbiota
Zoetendal, E. G., Rajilić-Stojanović, M. D., & de Vos, W. M. (2008) · Gut · doi:10.1136/gut.2007.133603 · Cited by 672 · see citing works
Obesity, Diabetes, and Gut Microbiota
Musso, G., Gambino, R., & Cassader, M. (2010) · Diabetes Care · doi:10.2337/dc10-0556 · Cited by 662 · see citing works
Matsuki, T., Watanabe, K., Fujimoto, J., Takada, T., & Tanaka, R. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.12.7220-7228.2004 · Cited by 656 · see citing works
Salonen, A., Nikkilä, J., Jalanka, J., Immonen, O., Rajilić-Stojanović, M. D., Kekkonen, R. A., Palva, A., & de Vos, W. M. (2010) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2010.02.007 · Cited by 592 · see citing works
Self-citationDiversity of the human gastrointestinal tract microbiota revisited
Rajilić‐Stojanović, M., Smidt, H., & De Vos, W. M. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01369.x · Cited by 559 · see citing works
Matsuki, T., Watanabe, K., Fujimoto, J., Kado, Y., Takada, T., Matsumoto, K., & Tanaka, R. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.1.167-173.2004 · Cited by 498 · see citing works
Rajilić‐Stojanović, M., Heilig, H. G. H. J., Molenaar, D., Kajander, K., Surakka, A., Smidt, H., & De Vos, W. M. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01900.x · Cited by 484 · see citing works
tana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01427.x · Cited by 474 · see citing works
Kang, S., Denman, S. E., Morrison, M., Yu, Z., Dore, J. M., Leclerc, M., & McSweeney, C. S. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21319 · Cited by 365 · see citing works
Liu, C., Finegold, S. M., Song, Y., & Lawson, P. A. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65208-0 · Cited by 359 · see citing works
'Gut health': a new objective in medicine?
Bischoff, S. C. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-24 · Cited by 338 · see citing works
Resilience of the Dominant Human Fecal Microbiota upon Short-Course Antibiotic Challenge
Cochetiere, M. F. D. L., Durand, T., Lepage, P., Bourreille, A., Galmiche, J. P., & Dore, J. M. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5588-5592.2005 · Cited by 333 · see citing works
Practical Regression and Anova using R
Faraway, J. J. (2002) · Cited by 331 · see citing works
Scanlan, P. D., Shanahan, F., O'Mahony, C., & Marchesi, J. R. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00312-06 · Cited by 330 · see citing works
Quality of life measures in health care. II: Design, analysis, and interpretation.
Fletcher, A. E., Gore, S. M., Jones, D., Fitzpatrick, R. M., Spiegelhalter, D. J., & Cox, D. (1992) · BMJ · doi:10.1136/bmj.305.6862.1145 · Cited by 319 · see citing works
Lindström, K., & Martínez-Romero, M. E. (2005) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.63744-0 · Cited by 317 · see citing works
Highlighting new phylogenetic specificities of Crohn's disease microbiota
Mondot, S., Kang, S., Furet, J., de Cárcer, D. A., McSweeney, C., Morrison, M., Marteau, P., Doré, J., & Leclerc, M. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21436 · Cited by 283 · see citing works
Abdominal Pain, Bloating, and Diarrheain the United States:
Sandler, R. S., Stewart, W. F., Liberman, J. N., Ricci, J. A., & Zorich, N. L. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005554103531 · Cited by 268 · see citing works
Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
Salonen, A., de Vos, W. M., & Palva, A. (2010) · Microbiology · doi:10.1099/mic.0.043257-0 · Cited by 264 · see citing works
Self-citationMetagenomic Sequencing of an In Vitro-Simulated Microbial Community
Morgan, J. L., Darling, A. E., & Eisen, J. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010209 · Cited by 248 · see citing works
Absence of Oxalobacter formigenes in cystic fibrosis patients: a risk factor for hyperoxaluria
Sidhu, H., Hoppe, B., Hesse, A., Tenbrock, K., Brömme, S., Rietschel, E., & Peck, A. B. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03038-4 · Cited by 233 · see citing works
Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome
Malinen, E. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i36.4532 · Cited by 215 · see citing works
Vanhoutte, T., Huys, G. R. B., Brandt, E. D., & Swings, J. (2004) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2004.03.001 · Cited by 215 · see citing works
The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat
McKernan, D. P., Fitzgerald, P., Dinan, T. G., & Cryan, J. F. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01520.x · Cited by 205 · see citing works
Metagenomics: Facts and Artifacts, and Computational Challenges
Wooley, J., & Ye, Y. (2010) · Journal of Computer Science and Technology · doi:10.1007/s11390-010-9306-4 · Cited by 187 · see citing works
Nonparametric Statistical Methods
Sijtsma, K., & Emons, W. H. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-044894-7.01353-1 · Cited by 174 · see citing works
van den Bogert, B., de Vos, W. M., Zoetendal, E. G., & Kleerebezem, M. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.02477-10 · Cited by 174 · see citing works
Oxalobacter formigenes and its role in oxalate metabolism in the human gut
Stewart, C. S., Duncan, S. H., & Cave, D. R. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00864-4 · Cited by 146 · see citing works
Vlieg, J. E. V. H., Veiga, P., Zhang, C., Derrien, M., & Zhao, L. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.12.004 · Cited by 134 · see citing works
A gene expression bar code for microarray data
Zilliox, M. J., & Irizarry, R. A. (2007) · Nature Methods · doi:10.1038/nmeth1102 · Cited by 125 · see citing works
Ufnar, J. A., Wang, S., Christiansen, J. M., Yampara-Iquise, H., Carson, C. A., & Ellender, R. D. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.02989.x · Cited by 123 · see citing works
Impact of irritable bowel syndrome (IBS) on health-related quality of life (HRQOL)
Amouretti, M., Le Pen, C., Gaudin, A.-F., Bommelaer, G., Frexinos, J., Ruszniewski, P., Poynard, T., Maurel, F., Priol, G., & El Hasnaoui, A. (2006) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(06)73160-8 · Cited by 110 · see citing works
Engelbrektson, A. L., Korzenik, J. R., Pittler, A., Sanders, M. E., Klaenhammer, T. R., Leyer, G. J., & Kitts, C. L. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47615-0 · Cited by 95 · see citing works
In defence of phytochemical-rich dietary patterns
McKeown, N. M., & Jacobs, D. R. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000656 · Cited by 89 · see citing works
Sekelja, M., Berget, I., Næs, T., & Rudi, K. (2010) · The ISME Journal · doi:10.1038/ismej.2010.129 · Cited by 88 · see citing works
Maukonen, J., Mättö, J., Satokari, R. M., Söderlund, H., Mattila, T., & Saarela, M. (2006) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2006.00179.x · Cited by 69 · see citing works
Development of a Questionnaire to Measure Quality of Life in Patients with Irritable Bowel Syndrome
Wong, E. Y. L., Guyatt, G. H., Cook, D. J., Griffith, L. E., & Irvine, E. J. (1998) · The European Journal of Surgery · doi:10.1080/11024159850191247 · Cited by 57 · see citing works
Absence of Oxalobacter Formigenes in Cystic Fibrosis Patients: A Risk Factor for Hyperoxaluria
Sidhu, H., Höppe, B., Hesse, A., Tenbrock, K., Bromme, S., Rietschel, E., & Peck, A. B. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(05)69046-5 · Cited by 53 · see citing works
Analysis of treatment effects on the microbial ecology of the human intestine
Engelbrektson, A. L., Korzenik, J. R., Sanders, M. E., Clement, B., Leyer, G. J., Klaenhammer, T. R., & Kitts, C. L. (2006) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2006.00112.x · Cited by 51 · see citing works
Lahti, L., Elo, L. L., Aittokallio, T. A., & Samuel Kaski, A. (2009) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2009.38 · Cited by 42 · see citing works
Self-citationMethanogenic archaea in adult human faecal samples are inversely related to butyrate concentration
Abell, G. C. J., Conlon, M. A., & McOrist, A. L. (2006) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v18i3-4.7682 · Cited by 38 · see citing works
Methanogenic archaea in adult human faecal samples are inversely related to butyrate concentration
Abell, G. C. J., Conlon, M. A., & McOrist, A. L. (2006) · Microbial Ecology in Health and Disease · doi:10.1080/08910600601048969 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · see citing works
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
The first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182 · see citing works
Impacts of gut bacteria on human health and diseases
Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047493 · Cited by 1,055 · see citing works
Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.008 · Cited by 1,039 · see citing works
Biddle, A. S., Stewart, L. C., Blanchard, J. L., & Leschine, S. B. (2013) · Diversity · doi:10.3390/d5030627 · Cited by 1,031 · see citing works
Rossen, N. G., Fuentes, S., van der Spek, M. J., Tijssen, J. G., Hartman, J. H. A., Duflou, A., Löwenberg, M., van den Brink, G. R., Mathus-Vliegen, E. M. H., de Vos, W. M., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.03.045 · Cited by 921 · see citing works
Guinane, C. M., & Cotter, P. D. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13482996 · Cited by 846 · see citing works
Bäckhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V., & Finlay, B. B. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.10.012 · Cited by 836 · see citing works
Dewulf, E. M., Cani, P. D., Claus, S. P., Fuentes, S., Puylaert, P. G., Neyrinck, A. M., Bindels, L. B., de Vos, W. M., Gibson, G. R., Thissen, J.-P., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303304 · Cited by 825 · see citing works
The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific
Shkoporov, A. N., Clooney, A. G., Sutton, T. D. S., Ryan, F. J., Daly, K. M., Nolan, J. A., McDonnell, S. A., Khokhlova, E. V., Draper, L. A., Forde, A., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.09.009 · Cited by 737 · see citing works
Diversity of Bifidobacteria within the Infant Gut Microbiota
Turroni, F., Peano, C., Pass, D. A., Foroni, E., Severgnini, M., Claesson, M. J., Kerr, C., Hourihane, J., Murray, D., Fuligni, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036957 · Cited by 647 · see citing works
Salonen, A., Lahti, L., Salojärvi, J., Holtrop, G., Korpela, K., Duncan, S. H., Date, P., Farquharson, F., Johnstone, A. M., Lobley, G. E., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.63 · Cited by 626 · see citing works
Self-citationGut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
Mosca, A., Leclerc, M., & Hugot, J. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00455 · Cited by 612 · see citing works
Fate, activity, and impact of ingested bacteria within the human gut microbiota
Derrien, M., & van Hylckama Vlieg, J. E. T. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.03.002 · Cited by 605 · see citing works
Staudacher, H. M., Lomer, M. C. E., Anderson, J. L., Barrett, J. S., Muir, J. G., Irving, P. M., & Whelan, K. (2012) · The Journal of Nutrition · doi:10.3945/jn.112.159285 · Cited by 590 · see citing works
Mouse models for human intestinal microbiota research: a critical evaluation
Hugenholtz, F., & de Vos, W. M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2693-8 · Cited by 585 · see citing works
Optimizing methods and dodging pitfalls in microbiome research
Kim, D. J., Hofstaedter, C. E., Zhao, C., Mattei, L. M., Tanes, C., Clarke, E., Lauder, A. P., Sherrill-Mix, S. A., Chehoud, C., Kelsen, J. R., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0267-5 · Cited by 536 · see citing works
Hollister, E. B., Gao, C., & Versalovic, J. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.052 · Cited by 533 · see citing works
Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B., & Naliboff, B. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.027 · Cited by 512 · see citing works
The function of our microbiota: who is out there and what do they do?
Ottman, N., Smidt, H., de Vos, W. M., & Belzer, C. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00104 · Cited by 485 · see citing works
Fecal microbiota transplantation: in perspective
Gupta, S., Allen‐Vercoe, E., & Petrof, E. O. (2015) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15607414 · Cited by 484 · see citing works
Estaki, M., Pither, J., Baumeister, P., Little, J. P., Gill, S. K., Ghosh, S., Ahmadi-Vand, Z., Marsden, K. R., & Gibson, D. L. (2016) · Microbiome · doi:10.1186/s40168-016-0189-7 · Cited by 476 · see citing works
Role of the intestinal microbiome in health and disease: from correlation to causation
de Vos, W. M., & de Vos, E. A. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00505.x · Cited by 440 · see citing works
Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease
Chen, Y., Chen, D., Chen, L., Liu, J., Vaziri, N. D., Guo, Y. P., & Zhao, Y. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-018-1756-4 · Cited by 430 · see citing works
The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults
Lewis, D. A., Brown, R. L., Williams, J. P., White, P., Jacobson, S. K., Marchesi, J. R., & Drake, M. J. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00041 · Cited by 387 · see citing works
Techniques used to characterize the gut microbiota: a guide for the clinician
Fraher, M. H., O'Toole, P. W., & Quigley, E. M. M. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.44 · Cited by 385 · see citing works
Mohr, A. E., Jäger, R., Carpenter, K. C., Kerksick, C. M., Purpura, M., Townsend, J. R., West, N. P., Black, K., Gleeson, M., Pyne, D. B., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00353-w · Cited by 378 · see citing works
Applying the core microbiome to understand host–microbe systems
Risely, A. (2020) · Journal of Animal Ecology · doi:10.1111/1365-2656.13229 · Cited by 370 · see citing works
Microbiota conservation and BMI signatures in adult monozygotic twins
Tims, S., Derom, C., Jonkers, D. M., Vlietinck, R., Saris, W. H., Kleerebezem, M., de Vos, W. M., & Zoetendal, E. G. (2013) · The ISME Journal · doi:10.1038/ismej.2012.146 · Cited by 367 · see citing works
Jalanka-Tuovinen, J., Salojärvi, J., Salonen, A., Immonen, O., Garsed, K., Kelly, F. M., Zaitoun, A., Palva, A., Spiller, R. C., & de Vos, W. M. (2014) · Gut · doi:10.1136/gutjnl-2013-305994 · Cited by 340 · see citing works
Self-citationIrritable bowel syndrome: A microbiome-gut-brain axis disorder?
Kennedy, P. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14105 · Cited by 335 · see citing works
Aberrant gut microbiota composition at the onset of type 1 diabetes in young children
de Goffau, M. C., Fuentes, S., van den Bogert, B., Honkanen, H., de Vos, W. M., Welling, G. W., Hyöty, H., & Harmsen, H. J. M. (2014) · Diabetologia · doi:10.1007/s00125-014-3274-0 · Cited by 328 · see citing works
Wilson, B., & Whelan, K. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13700 · Cited by 326 · see citing works
Park, D.-Y., Ahn, Y.-T., Park, S.-H., Huh, C.-S., Yoo, S.-R., Yu, R., Sung, M.-K., McGregor, R. A., & Choi, M.-S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059470 · Cited by 317 · see citing works
McVey Neufeld, K. A., Mao, Y. K., Bienenstock, J., Foster, J. A., & Kunze, W. A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12049 · Cited by 299 · see citing works
Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults
Guarino, M. P. L., Altomare, A., Emerenziani, S., Rosa, C. D., Ribolsi, M., Balestrieri, P., Iovino, P., Rocchi, G., & Cicala, M. (2020) · Nutrients · doi:10.3390/nu12041037 · Cited by 286 · see citing works
The human microbiome as a reservoir of antimicrobial resistance
Penders, J., Stobberingh, E. E., Savelkoul, P. H. M., & Wolffs, P. F. G. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00087 · Cited by 272 · see citing works
Effects of bowel cleansing on the intestinal microbiota
Jalanka, J., Salonen, A., Salojärvi, J., Ritari, J., Immonen, O., Marciani, L., Gowland, P. A., Hoad, C. L., Garsed, K. C., Lam, C., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-307240 · Cited by 270 · see citing works
Self-citationLong‐term monitoring of the human intestinal microbiota composition
Rajilić-Stojanović, M. D., Heilig, H. G. H. J., Tims, S., Zoetendal, E. G., & de Vos, W. M. (2012) · Environmental Microbiology · doi:10.1111/1462-2920.12023 · Cited by 268 · see citing works
The gut microbiome: the role of a virtual organ in the endocrinology of the host
Evans, J. M., Morris, L. S., & Marchesi, J. R. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0131 · Cited by 264 · see citing works
Shetty, S. A., Hugenholtz, F., Lahti, L., Smidt, H., & de Vos, W. M. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw045 · Cited by 248 · see citing works
Self-citationGut microbiota, host health, and polysaccharides
Xu, X., Xu, P., Ma, C., Tang, J., & Zhang, X. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.12.009 · Cited by 245 · see citing works
Irritable bowel syndrome, the microbiota and the gut-brain axis
Raskov, H., Burcharth, J., Pommergaard, H.-C., & Rosenberg, J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1218585 · Cited by 243 · see citing works
Diverse Applications of Environmental DNA Methods in Parasitology
Bass, D., Stentiford, G. D., Littlewood, D. T. J., & Hartikainen, H. (2015) · Trends in Parasitology · doi:10.1016/j.pt.2015.06.013 · Cited by 243 · see citing works
Ringel-Kulka, T., Cheng, J., Ringel, Y., Salojärvi, J., Carroll, I., Palva, A., de Vos, W. M., & Satokari, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064315 · Cited by 230 · see citing works
Self-citationKorpela, K., Flint, H. J., Johnstone, A. M., Lappi, J., Poutanen, K. S., Dewulf, E. M., Delzenne, N. M., de Vos, W. M., & Salonen, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090702 · Cited by 228 · see citing works
Self-citationAssociation of dietary type with fecal microbiota in vegetarians and omnivores in Slovenia
Matijašić, B. B., Obermajer, T., Lipoglavšek, L., Grabnar, I., Avguštin, G., & Rogelj, I. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0607-6 · Cited by 220 · see citing works
The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls
Jalanka, J., Major, G., Murray, K., Singh, G., Nowak, A., Kurtz, C., Silos-Santiago, I., Johnston, J. M., de Vos, W. M., & Spiller, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020433 · Cited by 219 · see citing works
Impact of Diet on Human Intestinal Microbiota and Health
Salonen, A., & de Vos, W. M. (2014) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030212-182554 · Cited by 215 · see citing works
Self-citationIntestinal microbiota is a plastic factor responding to environmental changes
Candela, M., Biagi, E., Maccaferri, S., Turroni, S., & Brigidi, P. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.05.003 · Cited by 211 · see citing works
Rigsbee, L., Agans, R., Shankar, V., Kenche, H., Khamis, H. J., Michail, S., & Paliy, O. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.287 · Cited by 207 · see citing works
Recent Advances in Characterizing the Gastrointestinal Microbiome in Crohnʼs Disease
Wright, E. K., Kamm, M. A., Teo, S. M., Inouye, M., Wagner, J., & Kirkwood, C. D. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000382 · Cited by 207 · see citing works
Vallès, Y., Artacho, A., Pascual‐García, A., Ferrús, M. L., Gosalbes, M. J., Abellan, J. J., & Francino, M. P. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004406 · Cited by 202 · see citing works
Hiel, S., Bindels, L. B., Pachikian, B. D., Kalala, G., Broers, V., Zamariola, G., Chang, B. P. I., Kambashi, B., Rodriguez, J., Cani, P. D., et al. (2019) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz001 · Cited by 197 · see citing works
Lahti, L., Salonen, A., Kekkonen, R. A., Salojärvi, J., Jalanka, J., Palva, A., Orešič, M., & de Vos, W. M. (2013) · PeerJ · doi:10.7717/peerj.32 · Cited by 196 · see citing works
Self-citationKelley, C. F., Kraft, C. S., de Man, T. J., Duphare, C., Lee, H., Yang, J., Easley, K. A., Tharp, G. K., Mulligan, M. J., Sullivan, P. S., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.97 · Cited by 184 · see citing works
Martínez, I., Muller, C. E., & Walter, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069621 · Cited by 181 · see citing works
McDonald, J. A. K., Schroeter, K., Fuentes, S., Jong, I. H., Khursigara, C. M., de Vos, W. M., & Allen‐Vercoe, E. (2013) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2013.08.008 · Cited by 178 · see citing works
Temporal and technical variability of human gut metagenomes
Voigt, A. Y., Costea, P. I., Kultima, J. R., Li, S. S., Zeller, G., Sunagawa, S., & Bork, P. (2015) · Genome biology · doi:10.1186/s13059-015-0639-8 · Cited by 177 · see citing works
Fuentes, S., van Nood, E., Tims, S., Jong, I. H., ter Braak, C. J. F., Keller, J. J., Zoetendal, E. G., & de Vos, W. M. (2014) · The ISME Journal · doi:10.1038/ismej.2014.13 · Cited by 174 · see citing works
Dietary Factors: Major Regulators of the Gut's Microbiota
Moschen, A. R., Wieser, V., & Tilg, H. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.4.411 · Cited by 173 · see citing works
Estimating Time Since Death from Postmortem Human Gut Microbial Communities
Hauther, K. A., Cobaugh, K. L., Jantz, L. M., Sparer, T. E., & DeBruyn, J. M. (2015) · Journal of Forensic Sciences · doi:10.1111/1556-4029.12828 · Cited by 172 · see citing works
The impact of gut microbiota on kidney function and pathogenesis
Mahmoodpoor, F., Saadat, Y. R., Barzegari, A., Ardalan, M., & Vahed, S. Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.066 · Cited by 171 · see citing works
Dougal, K., de la Fuente, G., Harris, P. A., Girdwood, S. E., Pinloche, E., Geor, R. J., Nielsen, B. D., Schott, H. C., Elzinga, S., & Newbold, C. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087424 · Cited by 165 · see citing works
Identification of a Core Bacterial Community within the Large Intestine of the Horse
Dougal, K., de la Fuente, G., Harris, P. A., Girdwood, S. E., Pinloche, E., & Newbold, C. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077660 · Cited by 165 · see citing works
Vemuri, R., Shankar, E. M., Chieppa, M., Eri, R., & Kavanagh, K. (2020) · Microorganisms · doi:10.3390/microorganisms8040483 · Cited by 162 · see citing works
Cheng, J., Ringel‐Kulka, T., Jong, I. H., Ringel, Y., Carroll, I. M., de Vos, W. M., Salojärvi, J., & Satokari, R. M. (2015) · The ISME Journal · doi:10.1038/ismej.2015.177 · Cited by 160 · see citing works
Microbiome therapeutics: exploring the present scenario and challenges
Yadav, M., & Chauhan, N. S. (2021) · Gastroenterology report · doi:10.1093/gastro/goab046 · Cited by 157 · see citing works
Challenges of metabolomics in human gut microbiota research
Smirnov, K. S., Maier, T. V., Walker, A., Heinzmann, S. S., Forcisi, S., Martínez, I., Walter, J., & Schmitt‐Kopplin, P. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.03.006 · Cited by 153 · see citing works
Diet, Microbiota, and Metabolic Health: Trade-Off Between Saccharolytic and Proteolytic Fermentation
Korpela, K. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012830 · Cited by 153 · see citing works
Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease
Cheng, J., Kalliomäki, M., Heilig, H. G., Palva, A., Lähteenoja, H., de Vos, W. M., Salojärvi, J., & Satokari, R. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-113 · Cited by 152 · see citing works
Self-citationNylund, L., Satokari, R. M., Nikkilä, J., Rajilić-Stojanović, M. D., Kalliomäki, M. A., Isolauri, E., Salminen, S., & de Vos, W. M. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-12 · Cited by 152 · see citing works
Self-citationPiyathilake, C. J., Ollberding, N. J., Kumar, R., Macaluso, M., Alvarez, R. D., & Morrow, C. D. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0350 · Cited by 152 · see citing works
Rangel, I., Sundin, J., Fuentes, S., Repsilber, D., de Vos, W. M., & Brummer, R. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13399 · Cited by 151 · see citing works
Cui, M., Zhang, M., & Liu, K. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118530 · Cited by 150 · see citing works
Signature of Microbial Dysbiosis in Periodontitis
Meuric, V., Gall‐David, S. L., Boyer, É., Acuña-Amador, L., Martin, B., Fong, S. B., Barloy-Hubler, F., & Bonnaure‐Mallet, M. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.00462-17 · Cited by 149 · see citing works
Controversies and Recent Developments of the Low-FODMAP Diet.
Hill, P., Muir, J. G., & Gibson, P. R. (2017) · PubMed Central · Cited by 147 · see citing works
Wilson, B., Rossi, M., Dimidi, E., & Whelan, K. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy376 · Cited by 147 · see citing works
Xia, W.-J., Xu, M., Yu, X., Du, M., Li, X., Yang, T., Lu, L., Li, Y., Kang, K. B., Su, Q., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1854642 · Cited by 146 · see citing works
Azpiroz, F., Dubray, C., Bernalier‐Donadille, A., Cardot, J. ‐., Accarino, A. M., Serra, J., Wagner, A., Respondek, F., & Dapoigny, M. C. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12911 · Cited by 141 · see citing works
The interplay of extracellular matrix and microbiome in urothelial bladder cancer
Alfano, M., Canducci, F., Nebuloni, M., Clementi, M., Montorsi, F., & Salonia, A. (2015) · Nature Reviews Urology · doi:10.1038/nrurol.2015.292 · Cited by 134 · see citing works
The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems
Coates, M., Lee, M. J., Norton, D., & MacLeod, A. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02950 · Cited by 134 · see citing works
Altomare, A., Rosa, C. D., Imperia, E., Emerenziani, S., Cicala, M., & Guarino, M. P. L. (2021) · Nutrients · doi:10.3390/nu13051506 · Cited by 132 · see citing works
Lahtinen, P., Jalanka, J., Hartikainen, A. K., Mattila, E. J., Hillilä, M. T., Punkkinen, J., Koskenpato, J., Anttila, V., Tillonen, J., Satokari, R. M., et al. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15740 · Cited by 130 · see citing works
Disruption of the Human Gut Microbiota following Norovirus Infection
Nelson, A. M., Walk, S. T., Taube, S., Taniuchi, M., Houpt, E. R., Wobus, C. E., & Young, V. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048224 · Cited by 128 · see citing works
The Equine Gastrointestinal Microbiome: Impacts of Age and Obesity
Morrison, P. K., Newbold, C. J., Jones, E., Worgan, H. J., Grove‐White, D., Dugdale, A., Barfoot, C. F., Harris, P. A., & Argo, C. M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03017 · Cited by 127 · see citing works
Staudacher, H. M., & Whelan, K. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000021 · Cited by 126 · see citing works
Vincent, C., Miller, M. A., Edens, T. J., Mehrotra, S., Dewar, K., & Manges, A. R. (2016) · Microbiome · doi:10.1186/s40168-016-0156-3 · Cited by 124 · see citing works
Intestinal Microbiota and its Role in Irritable Bowel Syndrome (IBS)
Öhman, L., & Simrén, M. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0323-7 · Cited by 123 · see citing works
Buelow, E., Gonzalez, T. D. J. B., Fuentes, S., Piters, W. A. A. D. S., Lahti, L., Bayjanov, J. R., Majoor, E. A. M., Braat, J. C., van Mourik, M. S. M., Oostdijk, E. A. N., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0309-z · Cited by 121 · see citing works
Self-citationMicrobial community dynamics during the early stages of plant polymer breakdown in paddy soil
Wegner, C., & Liesack, W. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12815 · Cited by 120 · see citing works
The adult intestinal core microbiota is determined by analysis depth and health status
Salonen, A., Salojärvi, J., Lahti, L., & de Vos, W. M. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.03855.x · Cited by 114 · see citing works
Self-citationRethinking Diet to Aid Human–Microbe Symbiosis
Derrien, M., & Veiga, P. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.09.011 · Cited by 112 · see citing works
Zihler, A., Fuentes, S., Dostal, A., Payne, A. N., Vazquez-Gutierrez, P., Chassard, C., Grattepanche, F., de Vos, W. M., & Lacroix, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077772 · Cited by 111 · see citing works
Chang, B., Sang, L.-X., Wang, Y., Tong, J., Zhang, D., & Wang, B. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-151 · Cited by 109 · see citing works
Phylogenetic and Metabolic Tracking of Gut Microbiota during Perinatal Development
CHIERICO, F. D., Vernocchi, P., Petrucca, A., Paci, P., Fuentes, S., Praticò, G., Capuani, G., Masotti, A., Reddel, S., Russo, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137347 · Cited by 108 · see citing works
From pathogens to microbiota: How Drosophila intestinal stem cells react to gut microbes
Bonfini, A., Liu, X., & Buchon, N. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.02.008 · Cited by 106 · see citing works
Understanding the Intestinal Microbiome in Health and Disease
Costa, M., & Weese, J. S. (2018) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2017.11.005 · Cited by 106 · see citing works
Jalanka, J., Mattila, E. J., Jouhten, H., Hartman, J., de Vos, W. M., Arkkila, P., & Satokari, R. M. (2016) · BMC Medicine · doi:10.1186/s12916-016-0698-z · Cited by 105 · see citing works
- Authors
- Jalanka-Tuovinen, J., Salonen, A., Nikkilä, J., Immonen, O., Kekkonen, R., Lahti, L., Palva, A., & de Vos, W. M.
- Affiliations
- University of Helsinki (FI)
- Valio (Finland) (FI)
- Corresponding author
- Salonen, Anne
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-07-28
- Volume
- 6
- Issue
- 7
- Pages
- e23035
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3145776
- OpenAlex
- W2157800726
- Cited by
- 340
- References
- 75
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 19 · 2023: 17 · 2022: 23 · 2021: 20 · 2020: 23 · 2019: 19 · 2018: 19 · 2017: 34 · 2016: 32 · 2015: 28 · 2014: 31 · 2013: 44 · 2012: 20
- FWCI
- 12.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Tekes
- Valio
- Wageningen University and Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, healthy adults, temporal stability, core microbiome, intestinal symptoms, abdominal pain, bloating, Bifidobacterium, antibiotics, archaea, gut health
- MeSH terms
- Adult, Bacteria, DNA, Bacterial, Double-Blind Method, Feces, Female, Humans, Intestinal Diseases, Intestines, Longitudinal Studies, Male, Middle Aged, Phylogeny, RNA, Messenger, RNA, Ribosomal, 16S, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Biodiversity, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
