Relationships among gastrointestinal symptoms, sleep problems, challenging behaviour, comorbid psychopathology and autism spectrum disorder symptoms in children and adolescents with 15q duplication syndrome
Open accessAbstract
BACKGROUND: Comorbidity is the presence of at least two disorders in one person at one time. This study examined the frequency of gastrointestinal (GI) symptoms, sleep problems, comorbid psychopathology, challenging behaviour and autism spectrum disorder (ASD) symptoms in children and adolescents with duplication 15q syndrome (Dup15q), aged 3-17 years. This study also examined whether challenging behaviour in Dup15q is predicted by age, gender, presence of an intellectual disability, sleep problems, GI symptoms and comorbid psychopathology. METHOD: Parental measures were completed by 101 parents of children and adolescents with Dup15q. Questionnaires were composed of the Children's Sleep Habits Questionnaire, Behavior Problems Inventory - Short Form, GI Symptom Inventory, Social Communication Questionnaire and the Child Behavior Checklist. RESULTS: Sleep problems (94%), GI symptoms (87%) and challenging behaviour (100%) were common comorbidities represented in the sample in this study. Significant relationships were found between challenging behaviour and the presence of co-occurring sleep problems, GI symptoms, comorbid psychopathology and ASD symptoms. Further analysis revealed that these comorbidities also predicted challenging behaviour. CONCLUSION: This research demonstrated the importance of studying the relationships between GI symptoms, sleep problems, comorbid psychopathology, ASD symptoms and challenging behaviour in Dup15q and how these conditions can shape the Dup15q phenotype.
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Food selectivity in ASD, depending on its severity, can lead to a significant nutritional imbalance and be a direct contributing factor in the appearance of GIS.
“FS in ASD, depending on its severity, can lead to a significant nutritional imbalance [9,57,64,65], and be a direct contributing factor in the appearance of GIS.”
From Food Selectivity and Its Implications Associated with Gastrointestinal Disorders in Children with Autism Spectrum Disorders (2022) · cites this paper as [64]
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Robas, R., Tripathi, U., Rike, W. A., Sharma, O., & Stern, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.29.667422
“Therefore, food selectivity in ASD can lead to a significant nutritional imbalance that further contributes to GI problems (148–150).”
Robas, R., Tripathi, U., Rike, W. A., Sharma, O., & Stern, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199580
“Therefore, food selectivity in ASD can lead to a significant nutritional imbalance that further contributes to GI problems [116–118].”
Benítez-Provedo, C., García-Fernández, M., Gutiérrez‐Delicado, E., Alguacil, E. G., Cabrera, N. V. O., Garoz, B. F., Peñas, J. J. G., Casanova, N. L., Ballarà-Petitbò, M., Rodríguez, A. D., et al. (2026) · Epilepsia · doi:10.1002/epi.70311
- Authors
- Leader, G., Forde, J., Naughton, K., Maher, L., Arndt, S., & Mannion, A.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Leader, G.
- Venue
- Journal of Intellectual Disability Research
- Publisher
- Wiley
- Published
- 2020-10-18
- Volume
- 65
- Issue
- 1
- Pages
- 32-46
- ISSN
- 0964-2633 (ISSN-L)
- 1365-2788
- OpenAlex
- W3092874180
- Cited by
- 16
- References
- 80
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Intellectual Disability Research (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- gastrointestinal symptoms, sleep disorders, behavioral problems, comorbid psychopathology, autism symptoms, intellectual disability, children and adolescents, behavioral phenotypes
- MeSH terms
- Problem Behavior, Autism Spectrum Disorder, Adolescent, Mental Disorders, Child, Child, Preschool, Chromosomes, Human, Pair 15, Female, Gastrointestinal Diseases, Humans, Male, Psychopathology, Sleep, Sleep Wake Disorders, Trisomy, Comorbidity, Chromosome Duplication
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