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Cited by 76Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesFamily and Disability Support Research

Are gastrointestinal and sleep problems associated with behavioral symptoms of autism spectrum disorder?

Yang, Xiao-Lei, Liang, Shuang, Zou, Ming-Yang, Sun, Cai-Hong, Han, Pan-Pan, Jiang, Xi-Tao, Xia, Wei, Wu, Li-Jie·2018·Psychiatry Research
DOI 10.1016/j.psychres.2017.10.040
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Abstract

Many children with autism spectrum disorder (ASD) suffer from concurrent medical symptoms, including gastrointestinal (GI) and sleeping problems. However, there is limited information on the correlation between co-morbidities and autistic behavioral symptoms. In this study, we estimated the prevalence of GI and sleep problems in Chinese ASD children, examined the impacts of GI and sleep problems on autistic behavioral symptoms, and investigated the factors associated with GI and sleep problems. The survey included 169 ASD and 172 healthy children. Data regarding demographic characteristics, GI symptoms, sleep disturbances and behavioral symptoms were collected through questionnaires. GI and sleep problems were prevalent in Chinese ASD children. Moreover, ASD children with GI symptoms reported more severe ASD core symptoms than others. Autistic children's GI symptoms were associated with maternal sleep problems during pregnancy, child's 0-6 month food sources and picky eating. ASD children with sleep disturbances had lower performance in daily living skills, social cognition, social communication and intellectual development than ASD children without sleep disturbances. Sleep disturbances were associated with extra nutrient supply during lactation and feeding, and child's picky eating. Autistic children with GI or/and sleep problems may represent clinically relevant subtypes of ASD, for which targeted treatments may be needed.

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  • Children with ASD and GI pain may present with non-specific signs or symptoms including aggression, self-injury, irritability, abnormal vocalizations, motor signs, hyperactivity, changes in sleep patterns and/or anxiety.

    “Consequently, children with ASD and GI pain may present with non-specific signs or symptoms to express their discomfort, including aggression, self-injury, irritability, abnormal vocalizations (i.e. frequent swallowing, moaning), motor signs (i.e. grimacing, tapping), hyperactivity, changes in sleep patterns and/or anxiety 7325414.”

    From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [73]

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Authors
Yang, X.-L., Liang, S., Zou, M.-Y., Sun, C.-H., Han, P.-P., Jiang, X.-T., Xia, W., & Wu, L.-J.
Affiliations
Harbin Medical University (CN)
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2018-01
Volume
259
Pages
229-235
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2017.10.040
OpenAlex
W2765168094
Cited by
76
References
46
Citations by year
2026: 8 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 11 · 2020: 14 · 2019: 5 · 2018: 3
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Basic Research Program of China (2012CB517901)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
Keywords
autism spectrum disorder, gastrointestinal symptoms, sleep disorders, behavioral symptoms, comorbidities, picky eating, lactation nutrition, social communication, daily living skills, social cognition, intellectual development, Chinese children
MeSH terms
Autism Spectrum Disorder, Behavioral Symptoms, Child, Child, Preschool, China, Female, Gastrointestinal Diseases, Humans, Male, Surveys and Questionnaires, Sleep Wake Disorders, Social Behavior, Comorbidity, Prevalence, Case-Control Studies, Asian People

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