Endothelial nitric oxide deficiency promotes Alzheimer’s disease pathology

The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat

O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.

Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268 · cited 2× · see citing works

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975 · see citing works

Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study

Kukull, W. A., Higdon, R., Bowen, J. D., McCormick, W. C., Teri, L., Schellenberg, G. D., van Belle, G., Jolley, L., & Larson, E. B. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1737 · Cited by 806 · see citing works

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

Peng, H., Libby, P., & Liao, J. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.14214 · Cited by 703 · see citing works

Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

Hoshi, M. M., Sato, M., Matsumoto, S., Noguchi, A., Yasutake, K., Yoshida, N., & Sato, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1237107100 · Cited by 494 · see citing works

THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE

Dudzinski, D. M., Igarashi, J., Greif, D. M., & Michel, T. M. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121844 · Cited by 425 · see citing works

Nitric Oxide Signaling Contributes to Late-Phase LTP and CREB Phosphorylation in the Hippocampus

Lü, Y.-F., Kandel, E. R., & Hawkins, R. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10250.1999 · Cited by 409 · see citing works

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

Iadecola, C., Zhang, F., Niwa, K., Eckman, C., Turner, S. K., Fischer, E., Younkin, S., Borchelt, D. R., Hsiao, K. K., & Carlson, G. A. (1999) · Nature Neuroscience · doi:10.1038/5715 · Cited by 399 · see citing works

eNOS, metabolic syndrome and cardiovascular disease

Huang, P. L. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.03.005 · Cited by 357 · see citing works

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

Kummer, M. P., Hermes, M., Delekarte, A., Hammerschmidt, T., Kumar, S., Terwel, D., Walter, J., Pape, H.-C., König, S., Roeber, S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.001 · Cited by 336 · see citing works

Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid- Load in an Alzheimer's Disease Mouse Model

Puzzo, D., Staniszewski, A., Deng, S., Privitera, L., Leznik, E., Liu, S., Zhang, H., Feng, Y., Palmeri, A., Landry, D. W., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0864-09.2009 · Cited by 333 · see citing works

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

Doré, S., Kar, S., & Quirion, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4772 · Cited by 325 · see citing works

A Novel Function of Monomeric Amyloid β-Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage

Zou, K., Gong, J.-S., Yanagisawa, K., & Michikawa, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04833.2002 · Cited by 305 · see citing works

Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein

Niwa, K., Kazama, K., Younkin, L., Younkin, S. G., Carlson, G. A., & Iadecola, C. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00022.2002 · Cited by 286 · see citing works

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

Reneerkens, O. A. H., Rutten, K., Steinbusch, H. W. M., Blokland, A., & Prickaerts, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1273-x · Cited by 268 · see citing works

Coronary Hemodynamics in Endothelial NO Synthase Knockout Mice

Gödecke, A., Decking, U. K. M., Ding, Z., Hirchenhain, J., Bidmon, H. J., Gödecke, S., & Schrader, J. (1998) · Circulation Research · doi:10.1161/01.res.82.2.186 · Cited by 263 · see citing works

Tonic and phasic nitric oxide signals in hippocampal long-term potentiation

Hopper, R. A., & Garthwaite, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2259-06.2006 · Cited by 239 · see citing works

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

Nathan, C., Calingasan, N., Nezezon, J., Ding, A., Lucia, M. S., La Perle, K., Fuortes, M., Lin, M., Ehrt, S., Kwon, N. S., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051529 · Cited by 214 · see citing works

Methodological variables in the assessment of beta amyloid neurotoxicity

Busciglio, J. A., Lorenzo, A., & Yankner, B. A. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90065-6 · Cited by 210 · see citing works

Transient Hypoxia Stimulates Mitochondrial Biogenesis in Brain Subcortex by a Neuronal Nitric Oxide Synthase-Dependent Mechanism

Gutsaeva, D. R., Carraway, M. S., Suliman, H. B., It, D., Shitara, H., Yonekawa, H., & Piantadosi, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5654-07.2008 · Cited by 200 · see citing works

Protecting against vascular disease in brain

Faraci, F. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01310.2010 · Cited by 196 · see citing works

Endothelial Nitric Oxide Modulates Expression and Processing of Amyloid Precursor Protein

Austin, S. A., Santhanam, A. V. R., & Katušić, Z. S. (2010) · Circulation Research · doi:10.1161/circresaha.110.233080 · Cited by 186 · see citing works

Gene structure and organization of the human β‐secretase ( BACE ) promoter

Sambamurti, K., Kinsey, R., Maloney, B., Ge, Y., & Lahiri, D. K. (2004) · The FASEB Journal · doi:10.1096/fj.03-1378fje · Cited by 179 · see citing works

Amyloidogenicity of rodent and human βA4 sequences

Dyrks, T., Dyrks, E., Masters, C. L., & Beyreuther, K. T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81399-k · Cited by 158 · see citing works

Amyloid β‐protein (Aβ)1–40 protects neurons from damage induced by Aβ1–42 in culture and in rat brain

Zou, K., Kim, D. S., Kakio, A., Byun, K., Gong, J., Kim, J. W., Kim, M. J., Sawamura, N., Nishimoto, S., Matsuzaki, K., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02018.x · Cited by 154 · see citing works

Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease

Domek-Łopacińska, K., & Strosznajder, J. B. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8104-x · Cited by 127 · see citing works

Signaling from Blood Vessels to CNS Axons through Nitric Oxide

Garthwaite, G., Bartus, K., Malcolm, D. S., Goodwin, D., Kollb-Sielecka, M., Dooldeniya, C., & Garthwaite, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1528-06.2006 · Cited by 124 · see citing works

nNOS Expression in Reactive Astrocytes Correlates with Increased Cell Death Related DNA Damage in the Hippocampus and Entorhinal Cortex in Alzheimer's Disease

Šimić, G., Lucassen, P. J., Krsnik, Ž., Krušlin, B., Kostović, I., Winblad, B. G., & Bogdanović, N. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7448 · Cited by 116 · see citing works

Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation

Hongo, F., Garbán, H., Huerta‐Yépez, S., Vega, M. I., Jazirehi, A. R., Mizutani, Y., Miki, T., & Bonavida, B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.150 · Cited by 103 · see citing works

Differential regulation of BACE1 expression by oxidative and nitrosative signals

Kwak, Y.-D., Wang, R., Li, J. J., Zhang, Y., Xu, H., & Liao, F. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-17 · Cited by 102 · see citing works

Superior Water Maze Performance and Increase in Fear-Related Behavior in the Endothelial Nitric Oxide Synthase-Deficient Mouse Together with Monoamine Changes in Cerebellum and Ventral Striatum

Frisch, C., Dere, E., Silva, M. A. D. S., Gödecke, A., Schrader, J., & Huston, J. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06694.2000 · Cited by 96 · see citing works

The Effects of NOS2 Gene Deletion on Mice Expressing Mutated Human AβPP

Colton, C. A., Wilcock, D. M., Wink, D. A., Davis, J., Nostrand, W. E. V., & Vitek, M. P. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15405 · Cited by 92 · see citing works

Cerebromicrovascular Pathology in Alzheimer’s Disease Compared to Normal Aging

de la Torre, J. C. (2009) · Gerontology · doi:10.1159/000213834 · Cited by 86 · see citing works

Premature death and age-related cardiac dysfunction in male eNOS-knockout mice

Li, W., Mital, S. R., Ojaimi, C., Csiszár, A., Kaley, G., & Hintze, T. H. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.05.005 · Cited by 84 · see citing works

Does the radial arm maze necessarily test spatial memory?

Dubreuil, D., Tixier, C., Dutrieux, G., & Edeline, J. (2002) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(02)00023-0 · Cited by 74 · see citing works

Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy

Vasilevko, V., Passos, G. F., Quiring, D., Head, E., Kim, R. C., Fisher, M., & Cribbs, D. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05786.x · Cited by 72 · see citing works

Behavioural and cellular effects of exogenous amyloid-β peptides in rodents.

Chambon, C., Wegener, N., Gravius, A., & Danysz, W. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.024 · Cited by 64 · see citing works

Nitric Oxide Inhibits Endothelial IL-1β-induced ICAM-1 Gene Expression at the Transcriptional Level Decreasing Sp1 and AP-1 Activity

Berendji-Grün, D., Kolb-Bachofen, V., & Kröncke, K. (2001) · Molecular Medicine · doi:10.1007/bf03401964 · Cited by 60 · see citing works

DNA binding and regulatory effects of transcription factors SP1 and USF at the rat amyloid precursor protein gene promoter

Hoffman, P. W., & Chernak, J. M. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.12.2229 · Cited by 58 · see citing works

Amyloid peptide Aβ40 inhibits aggregation of Aβ42: Evidence from molecular dynamics simulations

Man, V. H., & Li, M. S. (2012) · The Journal of Chemical Physics · doi:10.1063/1.4730410 · Cited by 47 · see citing works

Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons

Arancio, O., Lev‐Ram, V., Tsien, R. Y., Kandel, E. R., & Hawkins, R. D. (1996) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(97)87907-7 · Cited by 45 · see citing works

Morphine via nitric oxide modulates beta-amyloid metabolism: a novel protective mechanism for Alzheimer's disease.

Pak, T. R., Cadet, P., Mantione, K. J., & Stefano, G. B. (2005) · PubMed · Cited by 43 · see citing works

Transgenic Expression of Intraneuronal Aβ ₄₂ But Not Aβ ₄₀ Leads to Cellular Aβ Lesions, Degeneration, and Functional Impairment without Typical Alzheimer's Disease Pathology

Abramowski, D., Rabe, S., Upadhaya, A. R., Reichwald, J., Danner, S., Staab, D., Capetillo-Zarate, E., Yamaguchi, H., Saido, T. C., Wiederhold, K.-H., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4586-11.2012 · Cited by 41 · see citing works

Supplementation of Nitric Oxide Attenuates AβPP and BACE1 Protein in Cerebral Microcirculation of eNOS-Deficient Mice

Austin, S. A., d’Uscio, L. V., & Katušić, Z. S. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121351 · Cited by 40 · see citing works

Unaltered radial maze performance and brain acetylcholine of the endothelial nitric oxide synthase knockout mouse

Dere, E., Frisch, C. M., Silva, M. A. D. S., Gödecke, A., Schrader, J., & Huston, J. P. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00382-7 · Cited by 35 · see citing works

Aged endothelial nitric oxide synthase knockout mice exhibit higher mortality concomitant with impaired open‐field habituation and alterations in forebrain neurotransmitter levels

Dere, E., Silva, M. A. D. S., Topic, B., Fiorillo, C., Li, J., Sadile, A. G., Frisch, C. M., & Huston, J. P. (2002) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2002.10402.x · Cited by 35 · see citing works

Novel nitrates as NO mimetics directed at Alzheimer's disease

Thatcher, G. R. J., Bennett, B. M., Dringenberg, H. C., & Reynolds, J. N. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6s614 · Cited by 28 · see citing works

Metallothionein-3 and neuronal nitric oxide synthase levels in brains from the Tg2576 mouse model of Alzheimer's disease

Martin, B. L., Tokheim, A. M., McCarthy, P. T., Doms, B. S., Davis, A. A., & Armitage, I. M. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-2390-7 · Cited by 28 · see citing works

Does Nitric Oxide Synthase Contribute to the Pathogenesis of Alzheimer's Disease?

Lahiri, D. K., Chen, D., GE, Y. ‐., Farlow, M. R., Kotwal, G. J., Kanthasamy, A. G., Ingram, D. K., & Greig, N. H. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1299.117 · Cited by 24 · see citing works

Nitric oxide synthase in innate and adaptive immunity: an update

Bogdan, C. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.01.003 · Cited by 862 · see citing works

Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging

Toth, P., Tarantini, S., Csiszar, A., & Ungvari, Z. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00581.2016 · Cited by 522 · see citing works

Nitric Oxide: Exploring the Contextual Link with Alzheimer’s Disease

Asiimwe, N., Yeo, S. G., Kim, M.-S., Jung, J., & Jeong, N. Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7205747 · Cited by 125 · see citing works

Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease

Csiszar, A., Tarantini, S., Fülöp, G. A., Kiss, T., Valcarcel-Ares, M. N., Galvan, V., Ungvari, Z., & Yabluchanskiy, A. (2017) · GeroScience · doi:10.1007/s11357-017-9991-9 · Cited by 93 · see citing works

The role of PI3K signaling pathway in Alzheimer’s disease

Pan, J., Yao, Q., Wang, Y., Chang, S., Li, C., Wu, Y., Shen, J., & Yang, R. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1459025 · Cited by 89 · see citing works

Emerging Roles of Endothelial Nitric Oxide in Preservation of Cognitive Health

Katusic, Z. S., d’Uscio, L. V., & He, T. (2023) · Stroke · doi:10.1161/strokeaha.122.041444 · Cited by 73 · see citing works

Nitric oxide/cGMP/CREB pathway and amyloid-beta crosstalk: From physiology to Alzheimer’s disease

Tropea, M. R., Gulisano, W., Vacanti, V., Arancio, O., Puzzo, D., & Palmeri, A. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.022 · Cited by 55 · see citing works

Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid

Austin, S. A., & Katusic, Z. S. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18822474 · Cited by 52 · see citing works

Asymmetric Dimethylarginine Is a Well Established Mediating Risk Factor for Cardiovascular Morbidity and Mortality—Should Patients with Elevated Levels Be Supplemented with Citrulline?

McCarty, M. (2016) · Healthcare · doi:10.3390/healthcare4030040 · Cited by 25 · see citing works

Primary Cilia and Cardiovascular Risk Factors in Alzheimer's Disease

Sunderman, C. L., Forero, K. V., Alorjani, Q., Buqaileh, R., Gallagher, G. M., Ventresca, S. M., Messer, W. S., & AbouAlaiwi, W. A. (2025) · Brain Sciences · doi:10.3390/brainsci15091004 · Cited by 1 · see citing works

EP2306 and EP2302, Two Novel Squalene Synthase Inhibitors, Stimulate Endothelial Nitric Oxide Synthase Expression in Cultured Endothelial Cells

Tavridou, A., Megaritis, G., Kourounakis, A. P., et al. (2007) · Endothelium · doi:10.1080/10623320701547216 · Cited by 8 · see citing works

Cigarette smoke exposure dose‐dependently alters the activity and coupling of endothelial nitric oxide synthase in the endothelium.

Wang, T., Druhan, L. J., Chen, C., & Zweier, J. L. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.628.21

Calmodulin-dependent and -independent Activation of Endothelial Nitric-oxide Synthase by Heat Shock Protein 90

Takahashi, S., & Mendelsohn, M. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212651200 · Cited by 80 · see citing works

Disabling a C-terminal Autoinhibitory Control Element in Endothelial Nitric-oxide Synthase by Phosphorylation Provides a Molecular Explanation for Activation of Vascular NO Synthesis by Diverse Physiological Stimuli

Lane, P. B., & Gross, S. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200258200 · Cited by 80 · see citing works

eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity

Rafikov, R., Fonseca, F. V., Kumar, S., Pardo, D., Darragh, C., Elms, S. C., Fulton, D. J., & Black, S. M. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0083 · Cited by 235 · see citing works