Mitochondrial and lysosomal biogenesis are activated following PINK 1/parkin‐mediated mitophagy
Open accessAbstract
Impairment of the autophagy-lysosome pathway is implicated with the changes in α-synuclein and mitochondrial dysfunction observed in Parkinson's disease (PD). Damaged mitochondria accumulate PINK1, which then recruits parkin, resulting in ubiquitination of mitochondrial proteins. These can then be bound by the autophagic proteins p62/SQSTM1 and LC3, resulting in degradation of mitochondria by mitophagy. Mutations in PINK1 and parkin genes are a cause of familial PD. We found a significant increase in the expression of p62/SQSTM1 mRNA and protein following mitophagy induction in human neuroblastoma SH-SY5Y cells. p62 protein not only accumulated on mitochondria, but was also greatly increased in the cytosol. Increased p62/SQSMT1 expression was prevented in PINK1 knock-down cells, suggesting increased p62 expression was a consequence of mitophagy induction. The transcription factors Nrf2 and TFEB, which play roles in mitochondrial and lysosomal biogenesis, respectively, can regulate p62/SQSMT1. We report that both Nrf2 and TFEB translocate to the nucleus following mitophagy induction and that the increase in p62 mRNA levels was significantly impaired in cells with Nrf2 or TFEB knockdown. TFEB translocation also increased expression of itself and lysosomal proteins such as glucocerebrosidase and cathepsin D following mitophagy induction. We also report that cells with increased TFEB protein have significantly higher PGC-1α mRNA levels, a regulator of mitochondrial biogenesis, resulting in increased mitochondrial content. Our data suggests that TFEB is activated following mitophagy to maintain autophagy-lysosome pathway and mitochondrial biogenesis. Therefore, strategies to increase TFEB may improve both the clearance of α-synuclein and mitochondrial dysfunction in PD. Damaged mitochondria are degraded by the autophagy-lysosome pathway and is termed mitophagy. Following mitophagy induction, the transcription factors Nrf2 and TFEB translocate to the nucleus, inducing the transcription of genes encoding for autophagic proteins such as p62, as well as lysosomal and mitochondrial proteins. We propose that these events maintain autophagic flux, replenish lysosomes and replace mitochondria.
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Shortly after mitophagy initiation by CCCP, the transcription factors Nrf2 and TFEB are both translocated to the nucleus.
“As expected, shortly after mitophagy initiation by CCCP, the transcription factors Nrf2 (Nuclear factor erythroid 2-related factor 2) and TFEB are both translocated to the nucleus [132].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [132]
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- Authors
- Ivankovic, D., Chau, K., Schapira, A. H. V., & Gegg, M. E.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Gegg, Matthew E.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2015-11-24
- Volume
- 136
- Issue
- 2
- Pages
- 388-402
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- PMC
- PMC4949652
- OpenAlex
- W1853148353
- Cited by
- 264
- References
- 62
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 28 · 2023: 30 · 2022: 33 · 2021: 28 · 2020: 24 · 2019: 24 · 2018: 16 · 2017: 18 · 2016: 9
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neurochemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council (MR/M006646/1)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- mitophagy, PINK1, Parkin, autophagy-lysosome pathway, mitochondrial biogenesis, lysosomal biogenesis, p62, Nrf2, TFEB, PGC-1α, alpha-synuclein, Parkinson's disease, glucocerebrosidase, cathepsin D, mitochondrial dysfunction, SH-SY5Y cells
- MeSH terms
- Sequestosome-1 Protein, Mitochondrial Precursor Protein Import Complex Proteins, PTEN-Induced Putative Kinase, Carbonyl Cyanide m-Chlorophenyl Hydrazone, Cell Nucleolus, Cytosol, Gene Expression Regulation, Heat-Shock Proteins, Humans, Lysosomes, Mitochondria, Neuroblastoma, Protein Kinases, Receptors, Cell Surface, Time Factors, Transfection, Tubulin, Gene Expression Regulation, Neoplastic, Membrane Transport Proteins, RNA, Small Interfering, Ubiquitin-Protein Ligases, Cell Line, Tumor, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Proton Ionophores, Mitophagy
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