The DOI matches its Crossref record; 83 of the 84 references it cites were found in a registry or an index.
3‐Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons
Open accessAbstract
During fasting and vigorous exercise, a shift of brain cell energy substrate utilization from glucose to the ketone 3‐hydroxybutyrate (3 OHB ) occurs. Studies have shown that 3 OHB can protect neurons against excitotoxicity and oxidative stress, but the underlying mechanisms remain unclear. Neurons maintained in the presence of 3 OHB exhibited increased oxygen consumption and ATP production, and an elevated NAD + / NADH ratio. We found that 3 OHB metabolism increases mitochondrial respiration which drives changes in expression of brain‐derived neurotrophic factor ( BDNF ) in cultured cerebral cortical neurons. The mechanism by which 3 OHB induces Bdnf gene expression involves generation of reactive oxygen species, activation of the transcription factor NF ‐κB, and activity of the histone acetyltransferase p300/ EP 300. Because BDNF plays important roles in synaptic plasticity and neuronal stress resistance, our findings suggest cellular signaling mechanisms by which 3 OHB may mediate adaptive responses of neurons to fasting, exercise, and ketogenic diets. image
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“the ketone β-hydroxybutyrate, which elevates NAD+ levels in neurons and has been shown to suppress Aβ and p-Tau pathologies and ameliorate behavioral deficits in a mouse model of AD”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Marosi et al., 2016
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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777
Brain Metabolism during Fasting*
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Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440
Fasting: molecular mechanisms and clinical applications
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Self-citationBridging animal and human models of exercise-induced brain plasticity
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Self-citationKetone bodies as signaling metabolites
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Puchalska, P., & Crawford, P. A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.022 · Cited by 1,682
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242
Self-citationNAD+ in Brain Aging and Neurodegenerative Disorders
Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790
Self-citationFlipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting
Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous, A. G., Leeuwenburgh, C., & Mattson, M. P. (2017) · Obesity · doi:10.1002/oby.22065 · Cited by 822
Self-citationBrain metabolism in health, aging, and neurodegeneration
Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752
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Metadata
- Authors
- Marosi, K., Kim, S. W., Moehl, K., Scheibye‐Knudsen, M., Cheng, A., Cutler, R., Camandola, S., & Mattson, M. P.
- Affiliations
- National Institute on Aging (US)
- University of Copenhagen (DK)
- Johns Hopkins University (US)
- Corresponding author
- Mattson, Mark P.
- ORCID
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2016-11-14
- Volume
- 139
- Issue
- 5
- Pages
- 769-781
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- PMC
- PMC5123937
- OpenAlex
- W2531271987
- Cited by
- 242
- References
- 84
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 25 · 2023: 24 · 2022: 34 · 2021: 32 · 2020: 27 · 2019: 25 · 2018: 19 · 2017: 17 · 2016: 2
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- beta-hydroxybutyrate, brain-derived neurotrophic factor, cortical neurons, brain energy metabolism, ketone bodies, mitochondrial respiration, reactive oxygen species, NF-κB, NAD+/NADH ratio, fasting, physical activity, ketogenic diet
- MeSH terms
- Animals, Cell Survival, Cells, Cultured, Cerebral Cortex, Energy Metabolism, Humans, Male, Mice, Inbred C57BL, Neurons, Gene Expression, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor, 3-Hydroxybutyric Acid, Mice, Rats, HEK293 Cells
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