3‐Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Wang, H., & Joseph, J. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00107-0 · Cited by 2,355

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

Brewer, G. J., Torricelli, J. R., Evege, E. K., & Price, P. J. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490350513 · Cited by 2,325

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777

Brain Metabolism during Fasting*

Owen, O. E., Morgan, A. P., Kemp, H. G., Sullivan, J. M., Herrera, M. G., & Cahill, G. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105650 · Cited by 1,662

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440

Fasting: molecular mechanisms and clinical applications

Longo, V. D., & Mattson, M. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.008 · Cited by 1,425

Bridging animal and human models of exercise-induced brain plasticity

Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975

Ketone bodies as signaling metabolites

Newman, J. C., & Verdin, E. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.09.002 · Cited by 966

Brain-derived neurotrophic factor in neurodegenerative diseases

Zuccato, C., & Cattaneo, E. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.54 · Cited by 947

Multiple promoters direct tissue-specific expression of the rat BDNF gene

Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858

BDNF regulates eating behavior and locomotor activity in mice

Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806

Diet‐induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle‐aged rats

Stranahan, A. M., Norman, E. D., Lee, K. M., Cutler, R. G., Telljohann, R. S., Egan, J. M., & Mattson, M. P. (2008) · Hippocampus · doi:10.1002/hipo.20470 · Cited by 765

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

Anson, R. M., Guo, Z., de Cabo, R., Iyun, T., Rios, M., Hagepanos, A., Ingram, D. K., Lane, M. A., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1035720100 · Cited by 732

Neurotrophin signalling in health and disease

Chao, M. V., Rajagopal, R., & Lee, F. S. (2006) · Clinical Science · doi:10.1042/cs20050163 · Cited by 628

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

Maalouf, M., Rho, J. M., & Mattson, M. P. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.002 · Cited by 584

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

Halagappa, V. K. M., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R. G., LaFerla, F. M., & Mattson, M. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.019 · Cited by 580

BDNF mediates adaptive brain and body responses to energetic challenges

Marosi, K., & Mattson, M. P. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.10.006 · Cited by 568

Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts

Chen, A. C.-H., Arany, P. R., Huang, Y., Tomkinson, E. M., Sharma, S. K., Kharkwal, G. B., Saleem, T., Mooney, D. J., Yull, F. E., Blackwell, T. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022453 · Cited by 526

Effects of β-hydroxybutyrate on cognition in memory-impaired adults

Reger, M. A., Henderson, S. T., Hale, C. M., Cholerton, B., Baker, L. D., Watson, G. S., Hyde, K., Chapman, D., & Craft, S. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00087-3 · Cited by 510

Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals

Silver, I. A., & Erecińska, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-05068.1994 · Cited by 489

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

Neufer, P. D., Bamman, M. M., Muoio, D. M., Bouchard, C., Cooper, D. M., Goodpaster, B. H., Booth, F. W., Kohrt, W. M., Gerszten, R. E., Mattson, M. P., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.011 · Cited by 474

Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice

Duman, C. H., Schlesinger, L., Russell, D. S., & Duman, R. S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.047 · Cited by 465

Neuroprotective and disease-modifying effects of the ketogenic diet

Gasior, M., Rogawski, M. A., & Hartman, A. L. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200609000-00009 · Cited by 445

Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536856100 · Cited by 428

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

Cheng, A., Wan, R., Yang, J.-L., Kamimura, N., Son, T. G., Ouyang, X., Luo, Y., Okun, E., & Mattson, M. P. (2012) · Nature Communications · doi:10.1038/ncomms2238 · Cited by 401

Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges

Cheng, A., Yang, Y., Zhou, Y., Maharana, C., Lu, D., Peng, W., Liu, Y., Wan, R., Marosi, K., Misiak, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.013 · Cited by 371

Exercise training increases mitochondrial biogenesis in the brain

Steiner, J. L., Murphy, E. A., McClellan, J. L., Carmichael, M. D., & Davis, J. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00343.2011 · Cited by 368

Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

Spires‐Jones, T. L., Grote, H., Varshney, N. K., Cordery, P. M., van Dellen, A., Blakemore, C. B., & Hannan, A. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1658-03.2004 · Cited by 367

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

Kashiwaya, Y., Bergman, C., Lee, J.-H., Wan, R., King, M. T., Mughal, M. R., Okun, E., Clarke, K., Mattson, M. P., & Veech, R. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.023 · Cited by 363

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in Cockayne syndrome

Scheibye-Knudsen, M., Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.005 · Cited by 352

Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice

Stranahan, A. M., Lee, K. M., Martin, B., Maudsley, S. R., Golden, E., Cutler, R. G., & Mattson, M. P. (2009) · Hippocampus · doi:10.1002/hipo.20577 · Cited by 335

Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.

Nakagawa, T., Tsuchida, A., Itakura, Y., Nonomura, T., Ono, M., Hirota, F., Inoue, T., Nakayama, C., Taiji, M., & Noguchi, H. (2000) · Diabetes · doi:10.2337/diabetes.49.3.436 · Cited by 323

Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

VanItallie, T. B., Nonas, C., Rocco, A. D., Boyar, K. L., Hyams, K., & Heymsfield, S. B. (2005) · Neurology · doi:10.1212/01.wnl.0000152046.11390.45 · Cited by 300

The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis

Trejo, J. L., Llorens-Martı́n, M., & Torres‐Alemán, I. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.10.016 · Cited by 297

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

Devi, L., & Ohno, M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.191 · Cited by 282

Age and energy intake interact to modify cell stress pathways and stroke outcome

Arumugam, T. V., Phillips, T. M., Cheng, A., Morrell, C. H., Mattson, M. P., & Wan, R. (2009) · Annals of Neurology · doi:10.1002/ana.21798 · Cited by 282

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson’s disease

Levivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274

Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity

Greco, T., Glenn, T. C., Hovda, D. A., & Prins, M. L. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15610584 · Cited by 210 · cited 2×

Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

Dansen, T. B., Smits, L. M. M., van Triest, M. H., de Keizer, P. L. J., van Leenen, D., Koerkamp, M. G., Szypowska, A., Meppelink, A., Brenkman, A. B., Yodoi, J., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.194 · Cited by 201

Transient Hypoxia Stimulates Mitochondrial Biogenesis in Brain Subcortex by a Neuronal Nitric Oxide Synthase-Dependent Mechanism

Gutsaeva, D. R., Carraway, M. S., Suliman, H. B., It, D., Shitara, H., Yonekawa, H., & Piantadosi, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5654-07.2008 · Cited by 200

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

Wang, R., Li, J. J., Diao, S., Kwak, Y.-D., Liu, L., Zhi, L., Büeler, H., Bhat, N. R., Williams, R. W., Park, E. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.016 · Cited by 199

Ketone bodies in epilepsy

McNally, M. A., & Hartman, A. L. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07670.x · Cited by 194

Ketone bodies mediate antiseizure effects through mitochondrial permeability transition

‍Kim, D. Y., Simeone, K. A., Simeone, T. A., Pandya, J. D., Wilke, J. C., Ahn, Y., Geddes, J. W., Sullivan, P. G., & Rho, J. M. (2015) · Annals of Neurology · doi:10.1002/ana.24424 · Cited by 194

Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats

Marosi, K., Bori, Z., Hart, N., Sárga, L., Koltai, E., Radák, Z., & Nyakas, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.001 · Cited by 186

Extracellular Glucose in Rat Ventromedial Hypothalamus During Acute and Recurrent Hypoglycemia

de Vries, M. G., Arseneau, L. M., Lawson, M. E., & Beverly, J. L. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2767 · Cited by 181

Intermittent Food Deprivation Improves Cardiovascular and Neuroendocrine Responses to Stress in Rats

Wan, R., Camandola, S., & Mattson, M. P. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.1921 · Cited by 175

Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia

Gobbo, O. L., & O’Mara, S. M. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.017 · Cited by 174

Nuclear factor κB is a critical determinant in N‐methyl‐ d ‐aspartate receptor‐mediated neuroprotection

Lipsky, R. H., Xu, K., Zhu, D., Kelly, C. G., Terhakopian, A., Novelli, A., & Marini, A. M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00386.x · Cited by 172

Lifelong brain health is a lifelong challenge: From evolutionary principles to empirical evidence

Mattson, M. P. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.011 · Cited by 161

Molecular mechanisms underlying activity-dependent regulation of BDNF expression

Shieh, P. B., & Ghosh, A. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199910)41:1 · Cited by 160

BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1

Yang, J.-L., Lin, Y.-T., Chuang, P.-C., Bohr, V. A., & Mattson, M. P. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8270-x · Cited by 159

Exercise, Energy Intake, Glucose Homeostasis, and the Brain

van Praag, H., Fleshner, M., Schwartz, M. W., & Mattson, M. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2814-14.2014 · Cited by 157

Fasting is neuroprotective following traumatic brain injury

Davis, L. M., Pauly, J. R., Readnower, R. D., Rho, J. M., & Sullivan, P. G. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21628 · Cited by 149

Reciprocal Inhibition of p53 and Nuclear Factor-κB Transcriptional Activities Determines Cell Survival or Death in Neurons

Culmsee, C., Siewe, J., Junker, V., Retiounskaia, M., Schwarz, S., Camandola, S., El-Metainy, S., Behnke, H., Mattson, M. P., & Krieglstein, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08586.2003 · Cited by 147

BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II

Markham, A., Cameron, I., Franklin, P., & Spedding, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03578.x · Cited by 142

Sirtuin 3 Mediates Neuroprotection of Ketones against Ischemic Stroke

Yin, J., Han, P., Tang, Z., Liu, Q., & Shi, J. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.123 · Cited by 139

Caspase-Mediated Degradation of AMPA Receptor Subunits: A Mechanism for Preventing Excitotoxic Necrosis and Ensuring Apoptosis

Glazner, G. W., Chan, S. L., Lu, C., & Mattson, M. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03641.2000 · Cited by 134

Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations

Mattson, M. P., Duan, W., Wan, R., & Guo, Z. (2004) · Neurotherapeutics · doi:10.1602/neurorx.1.1.111 · Cited by 133

Brain-Derived Neurotrophic Factor Stimulates Energy Metabolism in Developing Cortical Neurons

Burkhalter, J., Fiumelli, H., Allaman, I., Chatton, J., & Martin, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08212.2003 · Cited by 133

Identity of SMCT1 (SLC5A8) as a neuron‐specific Na+‐coupled transporter for active uptake of l ‐lactate and ketone bodies in the brain

Martin, P. M., Gopal, E., Ananth, S., Zhuang, L., Itagaki, S., Prasad, B. M., Smith, S. B., Prasad, P. D., & Ganapathy, V. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03878.x · Cited by 132

Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype.

Marini, A. M., Jiang, X., Wu, X., Tian, F., Zhu, D., Okagaki, P., & Lipsky, R. H. (2004) · PubMed · Cited by 128

�-Hydroxybutyrate Activates the NF-κB Signaling Pathway to Promote the Expression of Pro-Inflammatory Factors in Calf Hepatocytes

Shi, X., Li, X., Li, D., Li, Y., Song, Y., Deng, Q., Wang, J., Zhang, Y., Ding, H., Yin, L., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358664 · Cited by 122

Dietary restriction started after spinal cord injury improves functional recovery

Plunet, W. T., Streijger, F., Lam, C. K., Lee, J. H. T., Liu, J., & Tetzlaff, W. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.011 · Cited by 117

Nuclear factor κB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2

Kiningham, K. K., Yong, X. U., Daosukho, C., POPOVA, B., & Clair, D. K. S. (2000) · Biochemical Journal · doi:10.1042/bj3530147 · Cited by 114

The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury

Prins, M. L., & Matsumoto, J. H. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046706 · Cited by 107

Regulation of NF‐κB Action by Reversible Acetylation

Greene, W. C., & Chen, L. (2004) · Novartis Foundation symposium · doi:10.1002/0470862637.ch15 · Cited by 102

Brain‐derived neurotrophic factor‐mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways

Markham, A., Cameron, I., Bains, R. S., Franklin, P., Kiss, J., Schwendimann, L., Gressèns, P., & Spedding, M. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07965.x · Cited by 98

Lack of promoter IV‐driven BDNF transcription results in depression‐like behavior

Sakata, K., Jin, L., & Jha, S. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00605.x · Cited by 98

The Contribution of Ketone Bodies to Basal and Activity-Dependent Neuronal Oxidation in Vivo

Chowdhury, G. M. I., Jiang, L., Rothman, D. L., & Behar, K. L. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.77 · Cited by 97

Mitochondria Mediate Tumor Necrosis Factor- α /NF- κ B Signaling in Skeletal Muscle Myotubes

Li, Y., Atkins, C. M., Sweatt, J. D., & Reid, M. B. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.1-97 · Cited by 90

Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability

Wan, R., Weigand, L. A., Bateman, R., Griffioen, K. J. S., Mendelowitz, D., & Mattson, M. P. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12656 · Cited by 87

Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein

Griffioen, K. J. S., Rothman, S. M., Ladenheim, B., Wan, R., Vranis, N. M., Hutchison, E. R., Okun, E., Cadet, J. L., & Mattson, M. P. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.07.008 · Cited by 68

Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenation

Sharma, J., Johnston, M. V., & Hossain, M. A. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-9 · Cited by 67

Brain-Derived Neurotrophic Factor Enhances the Expression of the Monocarboxylate Transporter 2 through Translational Activation in Mouse Cultured Cortical Neurons

Robinet, C., & Pellerin, L. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.208 · Cited by 62

An Atypical NF-κB-Regulated Pathway Mediates Phorbol Ester-Dependent Heme Oxygenase-1 Gene Activation in Monocytes

Naidu, S., Wijayanti, N., Santoso, S., Kietzmann, T., & Immenschuh, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4113 · Cited by 37

Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: An immunohistochemical study

Chiry, O., Fishbein, W. N., Merezhinskaya, N., Clarke, S., Galuske, R. A. W., Magistretti, P. J., & Pellerin, L. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.025 · Cited by 30

Augmentation of Normal and Glutamate-Impaired Neuronal Respiratory Capacity by Exogenous Alternative Biofuels

Laird, M. D., Clerc, P., Polster, B. M., & Fiskum, G. M. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0275-0 · Cited by 23

β-Hydroxybutyrate Increases Reactive Oxygen Species in Late but Not in Early Postimplantation Embryonic Cells In Vitro

Forsberg, H., Eriksson, U. J., Melefors, Ö., & Welsh, N. (1998) · Diabetes · doi:10.2337/diab.47.2.255 · Cited by 20

Increased activity of surviving locus ceruleus neurons in Alzheimer's disease

Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1

Untitled work

(1999) · doi:10.1002/(sici)1097-4547(19990715)57:2

Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

Puchalska, P., & Crawford, P. A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.022 · Cited by 1,682

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242

NAD+ in Brain Aging and Neurodegenerative Disorders

Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting

Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous, A. G., Leeuwenburgh, C., & Mattson, M. P. (2017) · Obesity · doi:10.1002/oby.22065 · Cited by 822

Brain metabolism in health, aging, and neurodegeneration

Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752

Ketone beta-hydroxybutyrate up-regulates BDNF expression through NF-κB as an adaptive response against ROS, which may improve neuronal bioenergetics and enhance neuroprotection (P3.090)

Kim, S. W., Marosi, K., & Mattson, M. P. (2017) · Neurology · doi:10.1212/wnl.88.16_supplement.p3.090 · Cited by 8

Beta-hydroxybutyrate Promotes the Expression of BDNF in Hippocampal Neurons under Adequate Glucose Supply

Hu, E., Du, H., Zhu, X., Wang, L., Shang, S., Wu, X., Lü, H., & Lu, X. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.06.036 · Cited by 92

P2‐149: EFFECT OF β‐HYDROXYBUTYRATE ON NEURONS AND ASTROCYTES

Koppel, S. J., Wilkins, H., Weidling, I. W., & Swerdlow, R. H. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.06.835

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