Fasting: molecular mechanisms and clinical applications

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Fuel Metabolism in Starvation

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Overview of caloric restriction and ageing

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The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

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Caloric Intake and Aging

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Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

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Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

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Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

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Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma

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Replicative and chronological aging in Saccharomyces cerevisiae

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Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

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Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

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Caloric restriction improves memory in elderly humans

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Aging, adiposity, and calorie restriction

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Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis

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Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

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Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

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Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

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Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

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Fasting and cancer treatment in humans: A case series report

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Long‐term effects of calorie or protein restriction on serum IGF‐1 and IGFBP‐3 concentration in humans

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Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism1,2

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Sir2 Blocks Extreme Life-Span Extension

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Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults

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A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

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Alternate-day fasting and chronic disease prevention: a review of human and animal trials

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“Control” laboratory rodents are metabolically morbid: Why it matters

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Lifespan extension in Caenorhabditis elegans by complete removal of food

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Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

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Dietary deprivation extends lifespan in <i>Caenorhabditis elegans</i>

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The Effects of Prolonged Fasting of the Body Composition and Reproductive Success of Female Polar Bears (Ursus maritimus)

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Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review

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The biochemistry of natural fasting at its limits

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Age and energy intake interact to modify cell stress pathways and stroke outcome

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Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age

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Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

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Fasting in king penguin. I. Hormonal and metabolic changes during breeding

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The effects of ghrelin on inflammation and the immune system.

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Effect of intermittent fasting and refeeding on insulin action in healthy men

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Short‐term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

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Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats

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Cardioprotection by Intermittent Fasting in Rats

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Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

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Body composition, energy expenditure, and plasma metabolites in long-term fasting geese

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Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies

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Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice

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Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and Delays Death of Wild-Type Yeast

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Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor

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Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

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Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report

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Thermoregulation in fasting emperor penguins under natural conditions

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Brain‐derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health

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Protein and lipid utilization during long-term fasting in emperor penguins

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Recruiting adaptive cellular stress responses for successful brain ageing

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Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet

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Five months of fasting in king penguin chicks: body mass loss and fuel metabolism

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Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats

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Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment

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Apparent Prolongation of the Life Span of Rats by Intermittent Fasting

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Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?

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Surgical Stress Resistance Induced by Single Amino Acid Deprivation RequiresGcn2in Mice

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Fasting in mood disorders: neurobiology and effectiveness. A review of the literature

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Intermittent fasting and dietary supplementation with 2‐deoxy‐ D ‐glucose improve functional and metabolic cardiovascular risk factors in rats

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Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats

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Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin

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Evolutionary aspects of human exercise—Born to run purposefully

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Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture.

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Intermittent fasting: A “new” historical strategy for controlling seizures?

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Dietary restriction started after spinal cord injury improves functional recovery

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Energy Intake and Amyotrophic Lateral Sclerosis

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Alternate-day fasting protects the rat heart against age-induced inflammation and fibrosis by inhibiting oxidative damage and NF-kB activation

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Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: Effect of alternate-day fasting

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Fasting in king penguin. II. Hormonal and metabolic changes during molt

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Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila melanogaster

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No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice

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Water conservation and protein metabolism in northern elephant seal pups during the postweaning fast

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Effect of Ramadan fasting on some indices of insulin resistance and components of the metabolic syndrome in healthy male adults

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Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice

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Uric acid and urea in relation to protein catabolism in long-term fasting geese

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Cognitive effects of a long-term weight reducing diet

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Adaptations to prolonged fasting in free-living weaned gray seal pups

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Whole-body and tissue protein synthesis during brief and prolonged fasting in the rat

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The effect of fasting and energy restricting diets on markers of glucose and insulin controls: a systematic review and meta-analysis of randomized controlled trials

Fatahi, S., Nazary-Vannani, A., Sohouli, M. H., Mokhtari, Z., Kord-Varkaneh, H., Moodi, V., Tan, S. C., Low, T. Y., Zanghelini, F., & Shidfar, F. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1798350 · Cited by 22 · see citing works

Intermittent Fasting: A Promising Approach for Preventing Vascular Dementia

Yoon, G., & Song, J. (2019) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2019.8.1.1 · Cited by 20 · see citing works

Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes

Laeger, T., Castaño-Martinez, T., Werno, M. W., Japtok, L., Baumeier, C., Jonas, W., Kleuser, B., & Schürmann, A. (2018) · Diabetologia · doi:10.1007/s00125-018-4595-1 · Cited by 17 · see citing works

Can Circadian Eating Pattern Adjustments Reduce Risk or Prevent Development of T2D?

Harris, C., & Czaja, K. (2023) · Nutrients · doi:10.3390/nu15071762 · Cited by 13 · see citing works

The effect of intermittent fasting diet in comparison with low-calorie diet on inflammation, lipid profile, glycemic index, liver fibrosis in patients with metabolic-associated fatty liver disease (MAFLD): a randomized controlled trial

Karimi, M., Akhgarjand, C., Houjaghani, H., Nejad, M. M., Sohrabpour, A. A., Poustchi, H., Mohammadi, H., Chamari, M., & Imani, H. (2025) · Clinical Therapeutics · doi:10.1016/j.clinthera.2025.01.007 · Cited by 12 · see citing works

Slow-Ageing Diets

Aiello, A., Caruso, C., & Accardi, G. (2019) · Encyclopedia of Gerontology and Population Aging · doi:10.1007/978-3-319-69892-2_134-1 · Cited by 8 · see citing works

Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity

Knäblein, J., & Huber, R. (2013) · Wiley eBooks · doi:10.1002/9783527669417.ch26

Population Attributable Fractions for Modifiable Factors of Longevity and Healthy Longevity Among the Late-Elderly Aged 75 Years or Older — China, 1998–2018

Zhou, J., Gao, X., Wei, Y., et al. (2023) · China CDC Weekly · doi:10.46234/ccdcw2023.005 · Cited by 2 · see citing works

Influence of Temperature and Nutrition on Adult Longevity of Microplitis tuberculiferWesmael

Li, J. (2010) · Journal of Hebei Agricultural Sciences · Cited by 1 · see citing works

Direct reprogramming 101

Takahashi, K. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2010.01169.x · Cited by 20 · see citing works

Predictors of Exceptional Longevity: Gender Differences in Effects of Early-Life and Midlife Conditions

Gavrilov, L. A., & Gavrilova, N. S. (2016) · Applied demography series · doi:10.1007/978-3-319-43688-3_6 · Cited by 1 · see citing works