The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation
Open accessAbstract
It is well known that sleep disorders are harmful to people's health and performance, and growing evidence suggests that sleep deprivation (SD) can trigger neuroinflammation in the brain. The nucleotide‐binding domain and leucine‐rich repeat protein‐3 (NLRP 3) inflammasome is reported to be relevant to the neuroinflammation induced by SD, but the regulatory signaling that governs the NLRP 3 inflammasome in SD is still unknown. Meanwhile, whether the regulatory action of antidepressants in astrocytes could affect the neuroinflammation induced by SD also remains obscure. In this study, we were the first to discover that the antidepressant fluoxetine, a type of specific serotonin reuptake inhibitor widely used in clinical practice, could suppress the neuroinflammation and neuronal apoptosis induced by SD. The main findings from this study are as follows: (i) SD stimulated the expression of activated NLRP 3 inflammasomes and the maturation of IL‐1β/18 via suppressing the phosphorylation of STAT 3 in astrocytes; (ii) SD decreased the activation of AKT and stimulated the phosphorylation of GSK‐3β, which inhibited the phosphorylation of STAT 3; (iii) the NLRP 3 inflammasome expression stimulated by SD was partly mediated by the P2X7 receptor; (iv) an agonist of STAT 3 could significantly abolish the expression of NLRP 3 inflammasomes induced by an agonist of the P2X7 receptor in primary cultured astrocytes; (v) the administration of fluoxetine could reverse the stimulation of NLRP 3 inflammasome expression and function by SD through elevating the activation of STAT 3. In conclusion, our present research suggests the promising possibility that fluoxetine could ameliorate the neuronal impairment induced by SD. image
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fluoxetine inhibits SD-induced stimulation of the NLRP3 inflammasome by the AKT/STAT3 and ERK/STAT3 pathways in vivo, and SD triggers depressive-like behaviors by stimulating astrocytic P2X7Rs.
“Furthermore, administration of fluoxetine effectively inhibits SD-induced stimulation of the NLRP3 inflammasome by the AKT/STAT3 and ERK/STAT3 pathways in vivo, and SD dramatically triggers depressive-like behaviors by stimulating astrocytic P2X 7 Rs. 41 , 155”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [155]
The Discussion (p. 17) and Figure 8 (p. 26) support the claim that fluoxetine suppresses SD-induced astrocytic NLRP3 inflammasome activity through ERK1/2- and AKT-mediated STAT3 activation in mice. The paper also links astrocytic P2X7R to SD-induced inflammasome formation, but it does not report that SD triggers depressive-like behaviors through that receptor; the depression-like behavior mentioned in the Introduction (p. 6) concerns a different study. (LLM, conf=0.88)
Experimental — accuracy not yet measuredNLRP3 inflammasome activation causes astrocytes to produce more IL-1β and IL-18.
“NLRP3 inflammasome activation causes astrocytes to produce more IL-1β and IL-18. 154 , 155”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [155]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The role of sleep in emotional brain function
Goldstein, A. N., & Walker, M. P. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153716 · Cited by 1,052 · see citing works
Metabolic consequences of sleep and sleep loss
Van Cauter, E., Spiegel, K., Tasali, E., & Leproult, R. (2008) · Sleep Medicine · doi:10.1016/s1389-9457(08)70013-3 · Cited by 812 · see citing works
Astrocytes: a central element in neurological diseases
Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1513-1 · Cited by 755 · see citing works
Self-citationInflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works
Sleep Loss Activates Cellular Inflammatory Signaling
Irwin, M. R., Wang, M., Ribeiro, D., Cho, H. J., Olmstead, R., Breen, E. C., Martinez-Maza, O., & Cole, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.004 · Cited by 467 · see citing works
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
Karmakar, M., Katsnelson, M. A., Dubyak, G. R., & Pearlman, E. (2016) · Nature Communications · doi:10.1038/ncomms10555 · Cited by 450 · see citing works
Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature
Franken, P., Dijk, D., Tobler, I., & Borbély, A. A. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.1.r198 · Cited by 400 · see citing works
INTERVAL BETWEEN ONSET OF SLEEP AND RAPID-EYE-MOVEMENT SLEEP AS AN INDICATOR OF DEPRESSION
Kupfer, D. J., & Foster, F. G. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92090-9 · Cited by 355 · see citing works
Sleep and circadian rhythms in mood disorders
Armitage, R. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00968.x · Cited by 344 · see citing works
Yue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0865-y · Cited by 334 · see citing works
Self-citationPelegrı́n, P., & Surprenant, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610351200 · Cited by 301 · see citing works
Sleep and Brain Energy Levels: ATP Changes during Sleep
Dworak, M., McCarley, R. W., Kim, T., Kalinchuk, A. V., & Basheer, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1423-10.2010 · Cited by 280 · see citing works
The role of microglia in the pathobiology of neuropathic pain development: what do we know?
Zhao, H., Alam, A., Chen, Q., Eusman, M. A., Pal, A., Eguchi, S., Wu, L., & Ma, D. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex006 · Cited by 249 · see citing works
Sleep duration, cardiovascular disease, and proinflammatory biomarkers
Grandner, M., Sands-Lincoln, Pak, & Garland (2013) · Nature and Science of Sleep · doi:10.2147/nss.s31063 · Cited by 246 · see citing works
An astroglial basis of major depressive disorder? An overview
Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222 · see citing works
Alcocer-Gómez, E., Casas-Barquero, N., Williams, M. R., Romero-Guillena, S. L., Cañadas-Lozano, D., Bullón, P., Sánchez-Alcazar, J. A., Navarro-Pando, J. M., & Cordero, M. D. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.028 · Cited by 215 · see citing works
Conti, B., Maier, R., Barr, A. M., Morale, M. C., Lu, X., Sanna, P. P., Bilbe, G., Hoyer, D., & Bartfai, T. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001897 · Cited by 205 · see citing works
Arbeloa, J., Pérez‐Samartín, A., Gottlieb, M., & Matute, C. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.014 · Cited by 188 · see citing works
Schmitt, L. I., Sims, R. E., Dale, N., & Haydon, P. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5689-11.2012 · Cited by 162 · see citing works
Biochemical Regulation of Sleep and Sleep Biomarkers
Clinton, J. M., Davis, C. J., Zielinski, M. R., Jewett, K. A., & Krueger, J. M. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1360 · Cited by 159 · see citing works
The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
Albalawi, F., Lu, W., Beckel, J. M., Lim, J. C., McCaughey, S. A., & Mitchell, C. H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00227 · Cited by 155 · see citing works
Lee, M., Choh, A. C., Demerath, E. W., Knutson, K. L., Duren, D. L., Sherwood, R. J., Sun, S. S., Chumlea, W. C., Towne, B., Siervogel, R. M., et al. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0110-1 · Cited by 152 · see citing works
Xia, M., Yang, L., Sun, G., Qi, S., & Li, B. (2017) · Psychopharmacology · doi:10.1007/s00213-016-4473-9 · Cited by 149 · see citing works
Self-citationVerkhratsky, A., Rodriguez, J. J., & Steardo, L. (2013) · The Neuroscientist · doi:10.1177/1073858413510208 · Cited by 146 · see citing works
Self-citationLetter: Nutrition in medicine.
Mackarness, R., & Taylor, G. (1976) · PubMed · Cited by 135 · see citing works
The homeostatic astroglia emerges from evolutionary specialization of neural cells
Verkhratsky, A., & Nedergaard, M. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0428 · Cited by 133 · see citing works
Self-citationP2X Receptors and Their Roles in Astroglia in the Central and Peripheral Nervous System
Illés, P., Verkhratsky, A., Burnstock, G., & Franke, H. (2011) · The Neuroscientist · doi:10.1177/1073858411418524 · Cited by 121 · see citing works
Self-citationAstrocyte-Mediated Ischemic Tolerance
Hirayama, Y., Ikeda‐Matsuo, Y., Notomi, S., Enaida, H., Kinouchi, H., & Koizumi, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4218-14.2015 · Cited by 114 · see citing works
Li, B., Zhang, S., Zhang, H., Nu, W., Cai, L., Hertz, L., & Peng, L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1306-5 · Cited by 109 · see citing works
Self-citationSleep deprivation hastens the antidepressant action of fluoxetine
Benedetti, F., Barbini, B., Lucca, A., Campori, E., Colombo, C., & Smeraldi, E. (1997) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02900200 · Cited by 85 · see citing works
Jian, Z., Ding, S., Deng, H., Wang, J., Yi, W., Wang, L., Zhu, S., Gu, L., & Xiong, X. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.002 · Cited by 79 · see citing works
Zielinski, M. R., Gerashchenko, D., Karpova, S. A., Konanki, V., McCarley, R. W., Sutterwala, F. S., Strecker, R. E., & Basheer, R. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.012 · Cited by 72 · see citing works
Hipólide, D. C., Moreira, K. D. M., Barlow, K. B. L., Wilson, A. A., Nóbrega, J. N., & Tufik, S. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.015 · Cited by 70 · see citing works
Alzheimer's disease: Innate immunity gone awry?
VanItallie, T. B. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.014 · Cited by 67 · see citing works
Chen, X., Zhang, X., Xue, L., Hao, C., Liao, W., & Wan, Q. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000468368 · Cited by 66 · see citing works
Hertz, L., Rothman, D. L., Li, B., & Peng, L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00025 · Cited by 66 · see citing works
Self-citationFu, H., Li, B., Hertz, L., & Peng, L. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.04.010 · Cited by 63 · see citing works
Self-citationFluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects
Peng, L., Gu, L., Li, B., & Hertz, L. (2014) · Current Neuropharmacology · doi:10.2174/1570159x12666140828221720 · Cited by 58 · see citing works
Self-citationZhu, Y., Liu, Z., Peng, Y.-P., & Qiu, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.07.017 · Cited by 56 · see citing works
Li, B., Zhang, S., Zhang, H., Hertz, L., & Peng, L. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100094 · Cited by 54 · see citing works
Self-citationŞahin, C., Albayrak, O., Akdeniz, T. F., Akbulut, Z., Demirel, G. Y., & Arıcıoğlu, F. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12604 · Cited by 50 · see citing works
Short-term sleep deprivation may alter the dynamics of hippocampal cell proliferation in adult rats
Junek, A., Rusak, B., & Semba, K. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.018 · Cited by 42 · see citing works
Liu, W., Wang, H., Wang, Y., Li, H., & Liu, J. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.102 · Cited by 36 · see citing works
Expression of Nucleoside Transporter in Freshly Isolated Neurons and Astrocytes from Mouse Brain
Li, B., Gu, L., Hertz, L., & Peng, L. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1146-5 · Cited by 34 · see citing works
Self-citationExpression level of P2X7 receptor is a determinant of ATP-induced death of mouse cultured neurons
Ohishi, A., Keno, Y., Marumiya, A., Sudo, Y., Uda, Y., Matsuda, K., Morita, Y., Furuta, T., Nishida, K., & Nagasawa, K. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.048 · Cited by 34 · see citing works
Dong, L., Li, B., Verkhratsky, A., & Peng, L. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3921-2 · Cited by 32 · see citing works
Self-citationLeptin impairs myogenesis in C2C12 cells through JAK/STAT and MEK signaling pathways
Pijet-Kucicka, M., Pijet, B., Litwiniuk, A., Pająk, B., Gajkowska, B., & Orzechowski, A. (2012) · Cytokine · doi:10.1016/j.cyto.2012.11.002 · Cited by 31 · see citing works
Giedke, H., Wormstall, H., & Haffner, H. T. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90062-l · Cited by 27 · see citing works
Leptin suppresses adenosine triphosphate‐induced impairment of spinal cord astrocytes
Li, B., Qi, S., Sun, G., Li, Y., Han, J., Zhu, Y., & Xia, M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23795 · Cited by 21 · see citing works
Self-citationSleep, brain energy levels, and food intake
Dworak, M., Kim, T., McCarley, R. W., & Basheer, R. (2011) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-011-0524-y · Cited by 19 · see citing works
Chiu, W., Lee, Y., Su, Y.-H., Wang, Y., Tsai, C., Hou, Y.-A., Wang, C., Huang, Y., Huang, C., Chou, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166453 · Cited by 17 · see citing works
Ren, J., Song, D., Bai, Q., Verkhratsky, A., & Peng, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00061 · Cited by 16 · see citing works
Self-citationThe Regulation of Sox2 and Sox9 Stimulated by ATP in Spinal Cord Astrocytes
Xia, M., & Zhu, Y. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0393-5 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,061 · see citing works
“154,155 The release of proin fl ammatory cytokines is the primary consequence of the activation of caspase-1, a component of the NLRP3 in fl ammasome.”
BackgroundSelf-citationFatigue, Sleep, and Autoimmune and Related Disorders
Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 266 · see citing works
Neural consequences of chronic sleep disruption
Zamore, Z. H., & Veasey, S. C. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.05.007 · Cited by 105 · see citing works
Li, X., Liang, S., Li, Z., Li, S., Xia, M., Verkhratsky, A., & Li, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00734 · Cited by 54 · see citing works
“Previously we have demonstrated that 6 h daily SD for 3 weeks triggers the activation of nucleotide-binding domain and leucine-rich repeat protein3 (NLRP3) inflammasomes, and increases astroglial secretion of IL-1β and IL-18 (7).”
BackgroundMethodInfluentialSelf-citationRole of Glia in the Regulation of Sleep in Health and Disease
Garofalo, S., Picard, K., Limatola, C., Nadjar, A., Pascual, O., & Tremblay, M. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190022 · Cited by 63 · see citing works
Xia, M., Li, Z., Li, S., Liang, S., Li, X., Chen, B., Zhang, M., Dong, C., Verkhratsky, A., Guan, D., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00524-4 · Cited by 55 · see citing works
Self-citationZhou, L., Yao, M., Tian, Z., Liu, S., Song, Y.-J., Ye, J., Li, G., Sun, Y., Cui, X., & Wang, Y. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15011 · Cited by 55 · see citing works
Astrocytes in Post-traumatic Stress Disorder
Li, B., Zhang, D., & Verkhratsky, A. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00845-6 · Cited by 54 · see citing works
Self-citationSupraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?
Kaufman, M. J., Kanayama, G., Hudson, J. I., & Pope, H. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.02.014 · Cited by 54 · see citing works
Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation
Lü, C., Lv, J., Jiang, N., Wang, H., Huang, H. M., Zhang, L., Li, S., Zhang, N., Fan, B., Liu, X., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6567 · Cited by 52 · see citing works
Zhu, G., Cassidy, S., Hiden, H., Woodman, S., Trenell, M. I., Gunn, D. A., Catt, M., Birch‐Machin, M. A., & Anderson, K. N. (2021) · Nature and Science of Sleep · doi:10.2147/nss.s323160 · Cited by 40 · see citing works
Iron induces two distinct Ca2+ signalling cascades in astrocytes
Guan, W., Xia, M., Ji, M. H., Chen, B., Li, S., Zhang, M., Liang, S., Chen, B., Gong, W., Dong, C., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02060-x · Cited by 40 · see citing works
Self-citationGlymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders
Zhang, D., Li, X., & Li, B. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.873697 · Cited by 40 · see citing works
Self-citationUnderstanding neuron-glia crosstalk and biological clocks in insomnia
Carvalhas-Almeida, C., Serra, J., Moita, J. J., Cavadas, C., & Álvaro, A. R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105100 · Cited by 39 · see citing works
The neuroprotective mechanism of lithium after ischaemic stroke
Chen, B., Zhang, M., Ji, M., Zhang, D., Chen, B., Gong, W., Li, X., Zhou, Y., Dong, C., Wen, G., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03051-2 · Cited by 37 · see citing works
Self-citationNLRP3 inflammasome activation mediates sleep deprivation-induced pyroptosis in mice
Fan, K., Yang, J., Gong, W.-Y., Pan, Y.-C., Zheng, P., & Yue, X. (2021) · PeerJ · doi:10.7717/peerj.11609 · Cited by 37 · see citing works
Camargo, A., Dalmagro, A. P., Platt, N., Rosado, A. F., Neis, V. B., Zeni, A. L. B., Kaster, M. P., & Rodrigues, A. L. S. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172971 · Cited by 30 · see citing works
Sleep deprivation and NLRP3 inflammasome: Is there a causal relationship?
Amini, M., Yousefi, Z., Ghafori, S. S., & Hassanzadeh, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1018628 · Cited by 33 · see citing works
Wang, J., Wu, X., Liang, W., Chen, M., Zhao, C., & Wang, X. (2020) · Nature and Science of Sleep · doi:10.2147/nss.s270045 · Cited by 27 · see citing works
Xia, M., Liang, S., Li, S., Ji, M. H., Chen, B., Zhang, M., Dong, C., Chen, B., Gong, W., Wen, G., et al. (2021) · Function · doi:10.1093/function/zqab003 · Cited by 25 · see citing works
Self-citationZhang, Y., Tan, S.-L., Du, J., Chen, Y., Jia, J., Feng, J., Liu, K., & Zhou, J. F. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107795 · Cited by 25 · see citing works
Li, Z., Lu, Y., Liang, S., Li, S., Chen, B., Zhang, M., Xia, M., Guan, D., Verkhratsky, A., & Li, B. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104689 · Cited by 21 · see citing works
Self-citationShort-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner
Cheng, Y., Kim, W., Wellman, L. L., Sanford, L. D., & Guo, M. (2021) · Life · doi:10.3390/life11101098 · Cited by 21 · see citing works
Chen, B., Zhang, M., Ji, M., Gong, W., Chen, B., Zorec, R., Stenovec, M., Verkhratsky, A., & Li, B. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03225-6 · Cited by 21 · see citing works
Self-citationJi, M. H., Gong, W., Wang, S., Zhang, D., Chen, B., Li, X., Wu, X., Cui, L., Feng, Y., Verkhratsky, A., et al. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03655-4 · Cited by 20 · see citing works
Self-citationAstroglial Serotonin Receptors as the Central Target of Classic Antidepressants
Verkhratsky, A., Parpura, V., Scuderi, C., & Li, B. (2021) · Advances in Neurobiology · doi:10.1007/978-3-030-77375-5_13 · Cited by 19 · see citing works
Self-citationImpact of Sleep Deprivation on Major Neuroinflammatory Signal Transduction Pathways
Mahalakshmi, A. M., Lokesh, P., Hediyal, T. A., Kalyan, M., Vichitra, C., Essa, M. M., Qoronfleh, M. W., Pandi-Perumal, S. R., & Chidambaram, S. B. (2022) · Sleep and Vigilance · doi:10.1007/s41782-022-00203-6 · Cited by 17 · see citing works
Outdoor nighttime light exposure (light pollution) is associated with Alzheimer’s disease
Voigt, R. M., Ouyang, B., & Keshavarzian, A. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1378498 · Cited by 18 · see citing works
The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs
Li, X., Wang, S., Zhang, D., Feng, Y., Liu, Y., Yu, W., Li, S., Cui, L., Harkany, T., Verkhratsky, A., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400024121 · Cited by 14 · see citing works
Self-citationZhao, X., Li, Z., Liang, S., Li, S., Ren, J., Li, B., Zhu, Y., & Xia, M. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104500 · Cited by 12 · see citing works
Self-citationGao, H., Tian, M., Geng, X., Zhao, J., Song, Y., Wu, B., Tian, X., Yang, Y., Ni, W., & Yang, H. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116218 · Cited by 11 · see citing works
Alboni, S., Tascedda, F., Uezato, A., Sugama, S., Chen, Z., Marcondes, M. C. G., & Conti, B. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02951-z · Cited by 13 · see citing works
Calvo‐Schimmel, A., Kober, K. M., Paul, S. M., Cooper, B. A., Harris, C., Shin, J., Hammer, M. J., Conley, Y. P., Dokiparthi, V., Olshen, A. B., et al. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.11.014 · Cited by 10 · see citing works
Editorial: Sleep and Mood Disorders
Verkhratsky, A., Nedergaard, M., Steardo, L., & Li, B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00981 · Cited by 9 · see citing works
Self-citationOzathaley, A., Kou, Z., Ma, Y., Luo, D., Chen, J., Liu, C., & Liu, Z. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114255 · Cited by 8 · see citing works
Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice
Gong, W., Li, X., Feng, Y., Ji, M. H., Zhang, D., Chen, B., Wang, S., Wu, X., Cui, L., Li, B., et al. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.02.042 · Cited by 8 · see citing works
Self-citationShared Mechanisms in Dementia and Depression: The Modulatory Role of Physical Exercise
de Souza, P. B., Rodrigues, A. L. S., & Felice, F. G. D. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70185 · Cited by 8 · see citing works
Wen, C., Li, Z., Li, C., Zheng, J., Wang, P., Chen, L., You, Q., & Ding, L. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.105823 · Cited by 7 · see citing works
Role of Glia in the Regulation of Sleep in Health and Disease
Garofalo, S., Picard, K., Limatola, C., Nadjar, A., Pascual, O., & Tremblay, M. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00121.x · Cited by 6 · see citing works
Chaihu-Longgu-Muli Decoction promotes sleep in mice with insomnia
Wang, P., Xin, S., Wang, Z., Yu, M., Wang, J., Li, J., & Li, M. (2023) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v22i5.15 · Cited by 4 · see citing works
Exploring the potential of drug repurposing for treating depression
Verma, C., Jain, K., Saini, A., Mani, I., & Singh, V. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.03.037 · Cited by 3 · see citing works
Lim, C. R., Ogawa, S., & Kumari, Y. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01523-z · Cited by 2 · see citing works
Gao, J., Chen, Y., Chen, Y., Gong, X., Zhang, Z., & Zhang, X. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107679 · Cited by 1 · see citing works
Xia, M., Guan, W., Ji, M. H., Li, S., Li, Z., Chen, B., Zhang, M., Liang, S., Chen, B., Gong, W., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.06.190652 · Cited by 1 · see citing works
Self-citationEpendymocytes control cerebrospinal fluid flow to the peripheral organs through periaxonal pathwayPreprint
Li, X., Wang, S., Zhang, D., Feng, Y., Liu, Y., Yu, W., Li, S., Cui, L., Harkany, T., Verkhratsky, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.09.560634 · Cited by 1 · see citing works
Self-citationVerkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00001-8
Self-citationNazarova, K. E., Kostromina, R. A., Malinovskaya, N. A., Хилажева, Е. Д., & Komleva, Y. K. (2024) · Molekulyarnaya Meditsina (Molecular medicine) · doi:10.29296/24999490-2023-03-02
Posttraumatic Stress Disorder (PTSD) and Glial Suppression
Kritikos, M., & Clouston, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_144-1
Posttraumatic Stress Disorder (PTSD) and Glial Suppression
Kritikos, M., & Clouston, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_144
- Authors
- Xia, M., Li, X., Yang, L., Ren, J., Sun, G., Qi, S., Verkhratsky, A., & Li, B.
- Affiliations
- First Hospital of China Medical University (CN)
- China Medical University (CN)
- Ikerbasque (ES)
- Corresponding author
- Li, Baoman
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2018-01-08
- Volume
- 146
- Issue
- 1
- Pages
- 63-75
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2772854176
- Cited by
- 53
- References
- 53
- Citations by year
- 2025: 4 · 2024: 9 · 2023: 5 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 4
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Funders
- Natural Science Foundation of Liaoning Province (201602834, [2015]1098)
- National Natural Science Foundation of China (20102104120002)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- fluoxetine, sleep deprivation, neuroinflammation, NLRP3 inflammasome, STAT3, astrocytes, P2X7 receptor, Akt/GSK-3β signaling, IL-1β, IL-18, neuronal apoptosis, antidepressants, serotonin reuptake inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
