Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants

Projections of Global Mortality and Burden of Disease from 2002 to 2030

Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386 · see citing works

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824 · see citing works

Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report

Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · cited 1× · see citing works

Sleep Drives Metabolite Clearance from the Adult Brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,499 · see citing works

Prevalence, Severity, and Unmet Need for Treatment of Mental Disorders in the World Health Organization World Mental Health Surveys

(2004) · JAMA · doi:10.1001/jama.291.21.2581 · Cited by 3,448 · see citing works

A review of central 5-HT receptors and their function

Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,150 · see citing works

The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013

Steel, Z., Marnane, C., Iranpour, C., Chey, T., Jackson, J. W., Patel, V., & Silove, D. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu038 · Cited by 2,846 · see citing works

Major depressive disorder

Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.65 · Cited by 2,269 · see citing works

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works

Molecular, pharmacological and functional diversity of 5-HT receptors

Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works

Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains

Bushong, E. A., Martone, M. E., Jones, Y. Z., & Ellisman, M. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00183.2002 · Cited by 1,578 · see citing works

Glial reduction in the subgenual prefrontal cortex in mood disorders

Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works

Impairment of paravascular clearance pathways in the aging brain

Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24271 · Cited by 1,521 · cited 2× · see citing works

Uniquely Hominid Features of Adult Human Astrocytes

Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · see citing works

Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature

Ferrari, A. J., Somerville, A. J., Baxter, A. J., Norman, R., Patten, S. B., Vos, T., & Whiteford, H. A. (2013) · Psychological Medicine · doi:10.1017/s0033291712001511 · Cited by 1,230 · see citing works

Glymphatic failure as a final common pathway to dementia

Nedergaard, M., & Goldman, S. A. (2020) · Science · doi:10.1126/science.abb8739 · Cited by 1,145 · cited 2× · see citing works

Current advances and trends in the treatment of depression

Blier, P., & de Montigny, C. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90315-8 · Cited by 1,113 · see citing works

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

Hallcher, L. M., & Sherman, W. R. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70391-3 · Cited by 1,102 · see citing works

Sequenced treatment alternatives to relieve depression (STAR*D): Rationale and design

Rush, A. J., Fava, M., Wisniewski, S. R., Lavori, P. W., Trivedi, M. H., Sackeim, H. A., Thase, M. E., Nierenberg, A. A., Quitkin, F. M., Kashner, T. M., et al. (2004) · Controlled Clinical Trials · doi:10.1016/s0197-2456(03)00112-0 · Cited by 1,076 · see citing works

Neural and developmental actions of lithium: A unifying hypothesis

Berridge, M. J., Downes, C. P., & Hanley, M. R. (1989) · Cell · doi:10.1016/0092-8674(89)90026-3 · Cited by 1,016 · see citing works

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

Kupfer, D. J., Frank, E., & Phillips, M. L. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60602-8 · Cited by 894 · see citing works

β-Amyloid accumulation in the human brain after one night of sleep deprivation

Shokri-Kojori, E., Wang, G.-J., Wiers, C. E., Demiral, S. B., Guo, M., Kim, S. W., Lindgren, E., Ramirez, V., Zehra, A., Freeman, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721694115 · Cited by 893 · see citing works

Prevalence, course, and comorbidity of insomnia and depression in young adults.

Buysse, D. J., Angst, J., Gamma, A., Ajdacic, V., Eich, D., & Rössler, W. (2008) · Sleep · doi:10.1093/sleep/31.4.473 · Cited by 858 · see citing works

Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works

Molecular biology of 5-HT receptors

Hannon, J., & Hoyer, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.020 · Cited by 815 · see citing works

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials.

Meltzer-Brody, S., Colquhoun, H., Riesenberg, R., Epperson, C. N., Deligiannidis, K. M., Rubinow, D. R., Li, H., Sankoh, A. J., Clemson, C., Schacterle, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31551-4 · Cited by 795 · see citing works

Culture and Depression

Kleinman, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmp048078 · Cited by 774 · see citing works

Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder

Cotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766 · see citing works

Astrocytes: a central element in neurological diseases

Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1513-1 · Cited by 755 · see citing works

Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder

Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634 · see citing works

Astrocyte-derived ATP modulates depressive-like behaviors

Cao, X., Li, L.-P., Wang, Q., Wu, Q., Hu, H.-H., Zhang, M., Fang, Y.-Y., Zhang, J., Li, S.-J., Xiong, W.-C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3162 · Cited by 615 · see citing works

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 606 · see citing works

Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms

Penninx, B. W. J. H. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.003 · Cited by 576 · cited 2× · see citing works

5-HT1A receptor function in major depressive disorder

Savitz, J. B., Lucki, I., & Drevets, W. C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.009 · Cited by 573 · see citing works

Anhedonia and motivational deficits in rats: Impact of chronic social stress

Rygula, R., Abumaria, N., Flügge, G., Fuchs, E., Rüther, E., & Havemann-Reinecke, U. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.009 · Cited by 554 · see citing works

Low glial numbers in the amygdala in major depressive disorder

Bowley, M. P., Drevets, W. C., Öngür, D., & Price, J. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01404-x · Cited by 503 · see citing works

Monoaminergic Neurotransmission: The History of the Discovery of Antidepressants from 1950s Until Today

Lopez-Munoz, F. J., & Álamo, C. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168001 · Cited by 476 · see citing works

The Prospective Association between Sleep Deprivation and Depression among Adolescents

ROBERTS, R. E., & Duong, H. T. (2014) · SLEEP · doi:10.5665/sleep.3388 · Cited by 459 · see citing works

5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants

Richardson-Jones, J. W., Craige, C. P., Guiard, B. P., Stephen, A., Metzger, K. L., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Beck, S. G., et al. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.003 · Cited by 450 · see citing works

A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system.

Dumuis, A., Bouhelal, R., Sebben, M., Cory, R. N., & Bockaert, J. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10130-2 · Cited by 450 · see citing works

Changes in the prevalence of major depression and comorbid substance use disorders in the United States between 1991-1992 and 2001-2002

Compton, W. M., Conway, K. P., Stinson, F. S., & Grant, B. F. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.12.2141 · Cited by 445 · see citing works

Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment

Czéh, B., Simon, M., Schmelting, B., Hiemke, C., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300982 · Cited by 434 · see citing works

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430 · see citing works

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-053013-062946 · Cited by 422 · see citing works

Depression and school performance in middle adolescent boys and girls

Fröjd, S. A., Nissinen, E. S., Pelkonen, M. U. I., MARTTUNEN, M. J., Koivisto, A., & Kaltiala‐Heino, R. (2007) · Journal of Adolescence · doi:10.1016/j.adolescence.2007.08.006 · Cited by 413 · see citing works

Abnormal Glutamate Receptor Expression in the Medial Temporal Lobe in Schizophrenia and Mood Disorders

Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408 · see citing works

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice

Ding, F., O’Donnell, J., Thrane, A. S., Zeppenfeld, D. M., Kang, H., Xie, L., Wang, F., & Nedergaard, M. (2013) · Cell Calcium · doi:10.1016/j.ceca.2013.09.001 · Cited by 391 · see citing works

Altered Editing of Serotonin 2C Receptor Pre-mRNA in the Prefrontal Cortex of Depressed Suicide Victims

Gurevich, I., Tamir, H., Arango, V., Dwork, A. J., Mann, J. J., & Schmauss, C. (2002) · Neuron · doi:10.1016/s0896-6273(02)00660-8 · Cited by 377 · see citing works

Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes

Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369 · see citing works

Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action

Lucas, G., Rymar, V. V., Du, J., Mnie‐Filali, O., Bisgaard, C. F., Manta, S., Lambás‐Señas, L., Wiborg, O., Haddjeri, N., Piñeyro, G., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.041 · Cited by 360 · see citing works

The mouse 5-hydroxytryptamine 1B receptor is localized predominantly on axon terminals

Boschert, U., Amara, D. A., Ségu, L., & Hen, R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90164-3 · Cited by 352 · see citing works

Treatment of Adult Depression in the United States

Olfson, M., Blanco, C., & Marcus, S. C. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.5057 · Cited by 352 · see citing works

Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19- 6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain

Saura, J., Kettler, R., Prada, M. D., & Richards, J. G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01977.1992 · Cited by 338 · see citing works

Serotonin receptors: from protein to physiological function and behavior

Sari, Y. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.008 · Cited by 332 · see citing works

The Prevalence Of Treated And Untreated Mental Disorders In Five Countries

Bijl, R. V., de Graaf, R., Hiripi, E., Kessler, R. C., Kohn, R., Offord, D. R., Üstün, T. B., Vicente, B., Vollebergh, W., Walters, E. E., et al. (2003) · Health Affairs · doi:10.1377/hlthaff.22.3.122 · Cited by 322 · see citing works

The Mood Spectrum in Unipolar and Bipolar Disorder: Arguments for a Unitary Approach

Cassano, G. B., Rucci, P., Frank, E., Fagiolini, A. M., Dell’Osso, L., Shear, M. K., & Kupfer, D. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1264 · Cited by 300 · see citing works

Serotonin 5-HT2C Receptors as a Target for the Treatment of Depressive and Anxious States: Focus on Novel Therapeutic Strategies

Millan, M. J. (2005) · Therapies · doi:10.2515/therapie:2005065 · Cited by 285 · see citing works

Direct Immunohistochemical Evidence of the Existence of 5‐HT1A Autoreceptors on Serotoninergic Neurons in the Midbrain Raphe Nuclei

Sotelo, C., Cholley, B., Mestikawy, S. E., GOZLAN, H., & Hamon, M. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00026.x · Cited by 285 · see citing works

5-HT1A Receptors, Gene Repression, and Depression: Guilt by Association

Albert, P. R., & Lemonde, S. (2004) · The Neuroscientist · doi:10.1177/1073858404267382 · Cited by 275 · see citing works

BDNF in sleep, insomnia, and sleep deprivation

Schmitt, K., Holsboer‐Trachsler, E., & Eckert, A. (2016) · Annals of Medicine · doi:10.3109/07853890.2015.1131327 · Cited by 275 · see citing works

Abnormal Glutamatergic Neurotransmission and Neuronal-Glial Interactions in Acute Mania

Öngür, D., Jensen, J. E., Prescot, A. P., Stork, C., Lundy, M. Y., Cohen, B. M., & Renshaw, P. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.014 · Cited by 272 · see citing works

Pharmacological Effects of Lu AA21004: A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

Mørk, A., Pehrson, A., Brennum, L. T., Nielsen, S. M., Zhong, H., Lassen, A. B., Miller, S., Westrich, L., Boyle, N. J., Sánchez, C., et al. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.189068 · Cited by 271 · see citing works

Astroglial cradle in the life of the synapse

Verkhratsky, A., & Nedergaard, M. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0595 · Cited by 266 · see citing works

Glial Physiology and Pathophysiology

Verkhratsky, A., & Butt, A. M. (2013) · Wiley eBooks · doi:10.1002/9781118402061 · Cited by 257 · see citing works

RNA Editing of the Human Serotonin 5-HT2C Receptor Alterations in Suicide and Implications for Serotonergic Pharmacotherapy

Niswender, C. M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00223-2 · Cited by 256 · see citing works

Stratification of astrocytes in healthy and diseased brain

Verkhratsky, A., Zorec, R., & Parpura, V. (2017) · Brain Pathology · doi:10.1111/bpa.12537 · Cited by 236 · see citing works

Adrenoceptors in brain: Cellular gene expression and effects on astrocytic metabolism and [Ca2+]i

Hertz, L., Lovatt, D., Goldman, S. A., & Nedergaard, M. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.03.019 · Cited by 234 · see citing works

Calcium signalling in astroglia

Verkhratsky, A., Rodriguez, J. J., & Parpura, V. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.039 · Cited by 224 · see citing works

The neuropharmacology of serotonin and noradrenaline in depression

Nutt, D. (2002) · International Clinical Psychopharmacology · doi:10.1097/00004850-200206001-00002 · Cited by 222 · see citing works

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

Allaman, I., Fiumelli, H., Magistretti, P. J., & Martin, J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2190-y · Cited by 211 · see citing works

Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system

Duxon, M. S., Flanigan, T. P., Reavley, A. C., Baxter, G. S., Blackburn, T. P., & Fone, K. C. F. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00480-0 · Cited by 210 · see citing works

Leptin dysregulation is specifically associated with major depression with atypical features: evidence for a mechanism connecting obesity and depression

Milaneschi, Y., Lamers, F., Bot, M., Drent, M. L., & Penninx, B. W. J. H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.023 · Cited by 209 · see citing works

Efficacy of antidepressants for depression in Alzheimer's disease: systematic review and meta-analysis

Orgeta, V., Tabet, N., Nilforooshan, R., & Howard, R. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161247 · Cited by 203 · see citing works

Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis

Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Oncotarget · doi:10.18632/oncotarget.21234 · Cited by 203 · see citing works

Epidemiology of Major Depressive Disorder in Mainland China: A Systematic Review

Gu, L., Xie, J., Long, J., Chen, Q., Chen, Q., Pan, R., Yan, Y., Wu, G., Liang, B., Tan, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065356 · Cited by 196 · see citing works

Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety

Richardson-Jones, J. W., Craige, C. P., Nguyen, T. H., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Guiard, B. P., Beck, S. G., Hen, R., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5836-10.2011 · Cited by 192 · see citing works

Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex

Michael, N., Erfurth, A., Ohrmann, P., G�ssling, M., Arolt, V., Heindel, W. L., & Pfleiderer, B. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1440-z · Cited by 187 · see citing works

Modulation of neurotransmitter release by the second messenger-activated protein kinases: Implications for presynaptic plasticity

Leenders, A. G. M., & SHENG, Z. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.10.012 · Cited by 182 · see citing works

Blockage of 5HT 2C serotonin receptors by fluoxetine (Prozac)

Ni, Y. G., & Miledi, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2036 · Cited by 177 · see citing works

How does pindolol improve antidepressant action?

Artigas, F., Celada, P., Laruelle, M. A., & Adell, A. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01682-5 · Cited by 174 · see citing works

Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.

Kursar, J. D., Nelson, D. L., Wainscott, D. B., & Baez, M. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09676-2 · Cited by 171 · see citing works

Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies

DIMATTEO, V., Giovanni, G. D., Pierucci, M., & Esposito, E. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00902-3 · Cited by 170 · see citing works

Rapid Enhancement of Glutamatergic Neurotransmission in Bipolar Depression Following Treatment with Riluzole

Brennan, B. P., Hudson, J. I., Jensen, J. E., McCarthy, J., Roberts, J. L., Prescot, A. P., Cohen, B. M., Pope, H. G., Renshaw, P. F., & Öngür, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.191 · Cited by 168 · see citing works

Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test

Redrobe, J. P., & Bourin, M. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00115-5 · Cited by 161 · see citing works

Mirtazapine: A Review of its Use in Major Depression and Other Psychiatric Disorders

Croom, K. F., Perry, C. M., & Plosker, G. L. (2009) · CNS Drugs · doi:10.2165/00023210-200923050-00006 · Cited by 158 · see citing works

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Mnie‐Filali, O., Faure, C., Lambás‐Señas, L., Mansari, M. E., Belblidia, H., Gondard, E., Etiévant, A., Scarna, H., Didier, A., Bérod, A., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.13 · Cited by 158 · see citing works

Reduced ventral striatal/ventral pallidal serotonin1B receptor binding potential in major depressive disorder

Murrough, J. W., Henry, S. E., Hu, J., Gallezot, J., Planeta‐Wilson, B., Neumaier, J. F., & Neumeister, A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1881-0 · Cited by 155 · see citing works

Characterization of the Novel Human Serotonin Receptor Subunits 5-HT3C,5-HT3D, and 5-HT3E

Niesler, B., Walstab, J., Combrink, S., Möller, D., Kapeller, J., Rietdorf, J., Bönisch, H., Göthert, M., Rappold, G., & Brüss, M. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.032144 · Cited by 152 · see citing works

Major Depression and Coronary Artery Disease in the Swedish Twin Registry

Kendler, K. S., Gardner, C. O., Fiske, A., & Gatz, M. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.94 · Cited by 150 · see citing works

Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system

Xia, M., Yang, L., Sun, G., Qi, S., & Li, B. (2017) · Psychopharmacology · doi:10.1007/s00213-016-4473-9 · Cited by 149 · see citing works

Astrogliopathology

Verkhratsky, A., Rodriguez, J. J., & Steardo, L. (2013) · The Neuroscientist · doi:10.1177/1073858413510208 · Cited by 146 · see citing works

Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects

Anisman, H., Du, L., Palkovits, M., Faludi, G., Kovács, G. G., Szontagh-Kisházi, P., Merali, Z., & Poulter, M. O. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0815 · Cited by 143 · see citing works

Through the looking glass: Examining neuroanatomical evidence for cellular alterations in major depression

Hercher, C., Turecki, G., & Mechawar, N. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.01.006 · Cited by 142 · see citing works

Lithium: the pharmacodynamic actions of the amazing ion

Brown, K. M., & Tracy, D. K. (2013) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125312471963 · Cited by 140 · see citing works

Serotonergic signaling: multiple effectors and pleiotropic effects

Masson, J., Emerit, M. B., Hamon, M., & Darmon, M. C. (2012) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.50 · Cited by 132 · see citing works

RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders

Iwamoto, K., & Kato, T. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00608-6 · Cited by 132 · see citing works

Interplay between Serotonin 5‐ HT 1Aand 5‐ HT 7Receptors in Depressive Disorders

Naumenko, V. S., Popova, N. K., Lacivita, E., Leopoldo, M., & Ponimaskin, E. G. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12247 · Cited by 131 · see citing works

Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models

Rajkumar, R., Radhakrishnan, M., & Borah, M. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f3cfd4 · Cited by 130 · see citing works

Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.

Inhorn, R. C., & Majerus, P. W. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47680-6 · Cited by 129 · see citing works

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

Dekeyne, A., la Cour, C. M., Gobert, A., Brocco, M., Lejeune, F., Serres, F., Sharp, T., Daszuta, A., Soumier, A., Papp, M., et al. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1177-9 · Cited by 126 · see citing works

Effects of fluoxetine on behavioral deficits evoked by chronic social stress in rats

RYGULA, R., ABUMARIA, N., DOMENICI, E., HIEMKE, C., & FUCHS, E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.017 · Cited by 126 · see citing works

Serotonin receptor expression along the dorsal–ventral axis of mouse hippocampus

Tanaka, K. F., Samuels, B. A., & Hen, R. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0038 · Cited by 124 · see citing works

Markers of Glutamate Synaptic Transmission and Plasticity Are Increased in the Anterior Cingulate Cortex in Bipolar Disorder

Eastwood, S. L., & Harrison, P. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.004 · Cited by 122 · see citing works

Estimating the Economic Burden of Depression in Children and Adolescents

Lynch, F. L., & Clarke, G. N. (2006) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2006.07.001 · Cited by 121 · see citing works

The Selective 5-HT2A Receptor Antagonist M100907 Enhances Antidepressant-Like Behavioral Effects of the SSRI Fluoxetine

Marek, G. J., Martín‐Ruiz, R., Abo, A., & Artigas, F. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300762 · Cited by 119 · see citing works

The possible role of 5-HT1B/D receptors in psychiatric disorders and their potential as a target for therapy

Moret, C., & Briley, M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00581-1 · Cited by 118 · see citing works

Effects of Ketamine on Resting-State EEG Activity and Their Relationship to Perceptual/Dissociative Symptoms in Healthy Humans

de la Salle, S., Choueiry, J., Shah, D. K., Bowers, H., McIntosh, J. F., Ilivitsky, V., & Knott, V. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00348 · Cited by 118 · see citing works

Riluzole elevates GLT-1 activity and levels in striatal astrocytes

Carbone, M., Duty, S., & Rattray, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.10.017 · Cited by 117 · see citing works

Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice

Guilloux, J., Mendez‐David, I., Pehrson, A. L., Guiard, B. P., Repérant, C., Orvoën, S., Gardier, A. M., Hen, R., Ebert, B., Miller, S., et al. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.014 · Cited by 117 · see citing works

Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs

Jenck, F., Moreau, J.-L., Mutel, V., et al. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90453-o · Cited by 117 · see citing works

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

Kinoshita, M., Hirayama, Y., Fujishita, K., Shibata, K., Shinozaki, Y., Shigetomi, E., Takeda, A., Le, H. P. N., Hayashi, H., Hiasa, M., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.05.036 · Cited by 115 · see citing works

The 5‐HT4 receptor subtype inhibits K+ current in colliculi neurones via activation of a cyclic AMP‐dependent protein kinase

Fagni, L., Dumuis, A., Sebben, M., et al. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09087.x · Cited by 113 · see citing works

The putative 5-HT1B receptor agonist CP-93,129 suppresses rat hippocampal 5-HT release in vivo: comparison with RU 24969

Hjorth, S., & Tao, R. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90177-r · Cited by 111 · see citing works

Effects of the 5‐HT2B receptor agonist, BW 723C86, on three rat models of anxiety

Kennett, G. A., Bright, F., Trail, B. K., et al. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15304.x · Cited by 111 · see citing works

The glial perspective of autism spectrum disorders

Zeidán‐Chuliá, F., Salmina, A. B., Malinovskaya, N. A., Noda, M., Verkhratsky, A., & Moreira, J. C. F. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.008 · Cited by 111 · see citing works

Ondansetron reduces the craving of biologically predisposed alcoholics

Johnson, B. A., Roache, J. D., Ait‐Daoud, N., Zanca, N. A., & Velázquez, M. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1002-9 · Cited by 109 · see citing works

Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation

Li, B., Zhang, S., Zhang, H., Nu, W., Cai, L., Hertz, L., & Peng, L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1306-5 · Cited by 109 · see citing works

Calcium Signalling in Mouse Bergmann Glial Cells Mediated by α1‐adrenoreceptors and H1 Histamine ‐ Receptors

Kirischuk, S., Tuschick, S., Verkhratsky, A., & Kettenmann, H. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01288.x · Cited by 109 · see citing works

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

Verkhratsky, A., Augusto‐Oliveira, M., Pivoriūnas, A., Popov, A., Brazhe, A., & Semyanov, A. V. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02465-3 · Cited by 108 · see citing works

Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment

Dremencov, E., Newman, M. E., Kinor, N., Blatman‐Jan, G., Schindler, C. J., Overstreet, D. H., & Yadid, G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.09.013 · Cited by 105 · see citing works

Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy

Albert, P. R. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00035 · Cited by 105 · see citing works

Riluzole in psychiatry: a systematic review of the literature

Zarate, C. A., & Manji, H. K. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.9.1223 · Cited by 104 · see citing works

Opposing roles for 5‐HT1Band 5‐HT3receptors in the control of 5‐HT release in rat hippocampusin vivo

Martin, K. F., Hannon, S. D., Phillips, I., & Heal, D. J. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14306.x · Cited by 103 · see citing works

Serotonin 2C receptor antagonists induce fast-onset antidepressant effects

Opal, M. D., Klenotich, S. C., Morais, M., Bessa, J., Winkle, J., Doukas, D., Kay, L. J., Sousa, N., & Dulawa, S. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.144 · Cited by 103 · see citing works

The 5-HT1B Receptor: A Novel Target for the Pathophysiology of Depression (Supplementary Tables)

Ruf, B. M., & Bhagwagar, Z. (2009) · Current Drug Targets · doi:10.2174/138945009789735192 · Cited by 100 · see citing works

The 5‐HT1B Receptors

Middlemiss, D. N., & Hutson, P. H. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16878.x · Cited by 100 · see citing works

Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

Wallace, A., Pehrson, A. L., Sánchez, C., & Morilak, D. A. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000571 · Cited by 97 · see citing works

Effects of Serotonin (5-Hydroxytryptamine, 5-HT) Reuptake Inhibition Plus 5-HT2A Receptor Antagonism on the Firing Activity of Norepinephrine Neurons

Szabo, S. T., & Blier, P. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.033282 · Cited by 97 · see citing works

Noradrenergic Augmentation of Escitalopram Response by Risperidone: Electrophysiologic Studies in the Rat Brain

Dremencov, E., Mansari, M. E., & Blier, P. U. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.015 · Cited by 96 · see citing works

Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase

Hirst, W. D., Cheung, N. Y., Rattray, M., Price, G. W., & Wilkin, G. P. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00206-x · Cited by 93 · see citing works

5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons

Meuser, T., Pietruck, C., Gabriel, A., et al. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02011-8 · Cited by 90 · see citing works

A cluster of novel serotonin receptor 3-like genes on human chromosome 3

Karnovsky, A., Gotow, L. F., McKinley, D. D., Piechan, J. L., Ruble, C., Mills, C. J., Schellin, K. A. B., Slightom, J. L., Fitzgerald, L. R., Benjamin, C. W., et al. (2003) · Gene · doi:10.1016/s0378-1119(03)00803-5 · Cited by 89 · see citing works

Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated

Kennett, G. A., Trail, B. K., & Bright, F. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00115-4 · Cited by 86 · see citing works

Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

Kajitani, N., Hisaoka‐Nakashima, K., Morioka, N., Okada‐Tsuchioka, M., Kaneko, M., Kasai, M., Shibasaki, C., Nakata, Y., & Takebayashi, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051197 · Cited by 85 · see citing works

Pharmacology and clinical potential of vortioxetine in the treatment of major depressive disorder

Alvarez, E., Artigas, F., & Perez, V. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s41387 · Cited by 84 · see citing works

Altered 5-HT2A and 5-HT4 Postsynaptic Receptors and Their Intracellular Signalling Systems IP3 and cAMP in Brains from Depressed Violent Suicide Victims

Rosel, P., Arranz, B., Urretavizcaya, M., Oros, M., San, L., & Navarro, M. A. (2004) · Neuropsychobiology · doi:10.1159/000077365 · Cited by 84 · see citing works

Targeting astrocytes in major depression

Peng, L., Verkhratsky, A., Gu, L., & Li, B. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1095094 · Cited by 83 · see citing works

Recent advances in (patho)physiology of astroglia

Verkhratsky, A., & Parpura, V. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.108 · Cited by 82 · see citing works

Quantitative Analysis of [ 11 C]AZ10419369 Binding to 5-HT 1B Receptors in Human Brain

Varnäs, K., Nyberg, S., Halldin, C., Varrone, A., Takano, A., Karlsson, P., Andersson, J. D., McCarthy, D. J., Smith, M., Pierson, M. E., et al. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.55 · Cited by 81 · see citing works

Identification of 5‐hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes

Hirst, W. D., Price, G. W., Rattray, M., & Wilkin, G. P. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700921 · Cited by 81 · see citing works

Immunohistochemical Staining and Enzyme Activity Measurements Show myo‐Inositol‐1‐Phosphate Synthase to Be Localized in the Vasculature of Brain

Wong, Y.-H. H., Kalmbach, S., Hartman, B. K., & Sherman, W. R. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05682.x · Cited by 80 · see citing works

GluR_5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic depressives

Benes, F. M., Todtenkopf, M. S., & Kostoulakos, P. (2001) · Hippocampus · doi:10.1002/hipo.1065 · Cited by 79 · see citing works

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence

Johnson, B., Roache, J. D., Ait‐Daoud, N., Javors, M. A., Harrison, J. K., Elkashef, A. M., Mojsiak, J., Li, S., & Bloch, D. A. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.02.011 · Cited by 78 · see citing works

Serotonin 1A receptor ligands act on norepinephrine neuron firing through excitatory amino acid and GABAA receptors: A microiontophoretic study in the rat locus coeruleus

Szabo, S. T., & Blier, P. U. (2001) · Synapse · doi:10.1002/syn.10009 · Cited by 78 · see citing works

Unraveling Monoamine Receptors Involved in the Action of Typical and Atypical Antipsychotics on Glutamatergic and Serotonergic Transmission in Prefrontal Cortex

López-Gil, X., Artigas, F., & Adell, A. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361416 · Cited by 78 · see citing works

The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder

Sahli, Z. T., Banerjee, P., & Tarazi, F. I. (2016) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2016.1160051 · Cited by 78 · see citing works

RNA splicing and editing modulation of 5-HT2C receptor function: relevance to anxiety and aggression in VGV mice

Martin, C. B. P., Ramond, F., Farrington, D. T., Aguiar, A. S., Chevarin, C., Berthiau, A.-S., Caussanel, S., Lanfumey, L., Herrick‐Davis, K., Hamon, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.171 · Cited by 77 · see citing works

Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression

Shirayama, Y., Takahashi, M., Osone, F., Hara, A., & Okubo, T. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.11.006 · Cited by 76 · see citing works

Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety

Kennett, G. A., Bailey, F., Piper, D. C., et al. (1995) · Psychopharmacology · doi:10.1007/bf02245837 · Cited by 72 · see citing works

The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide

Zielinski, M. R., Gerashchenko, D., Karpova, S. A., Konanki, V., McCarley, R. W., Sutterwala, F. S., Strecker, R. E., & Basheer, R. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.012 · Cited by 72 · see citing works

The effect of GR38032F, novel 5‐HT3‐receptor antagonist on gastric emptying in the guinea‐pig

Costall, B., Gunning, S. J., Naylor, R. J., et al. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb10280.x · Cited by 71 · see citing works

Reduced 5-HT1B receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder

Tiger, M., Rück, C., Forsberg, A., Varrone, A., Lindefors, N., Halldin, C., Farde, L., & Lundberg, J. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.05.011 · Cited by 70 · see citing works

5-HT _2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional ‘serotonin-specific reuptake inhibitors’

Zhang, S., Li, B., Lovatt, D., Xu, J., Song, D., Goldman, S. A., Nedergaard, M., Hertz, L., & Peng, L. (2010) · Neuron Glia Biology · doi:10.1017/s1740925x10000141 · Cited by 69 · see citing works

5-HT Reuptake Inhibitors with 5-HT1B/1DAntagonistic Activity: A New Approach toward Efficient Antidepressants

Matzen, L., van Amsterdam, C., Rautenberg, W., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm9811054 · Cited by 69 · see citing works

Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees

Schulze, T. G., Buervenich, S., Badner, J. A., Steele, C. J. M., Detera‐Wadleigh, S. D., Dick, D. M., Foroud, T., Cox, N. J., MacKinnon, D. F., Potash, J. B., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.004 · Cited by 68 · see citing works

Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats

Moreau, J., Jenck, F., Martin, J. R., et al. (1993) · Psychopharmacology · doi:10.1007/bf02246963 · Cited by 66 · see citing works

Physiology of Astroglial Excitability

Verkhratsky, A., Semyanov, A. V., & Zorec, R. (2020) · Function · doi:10.1093/function/zqaa016 · Cited by 66 · see citing works

Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

Hertz, L., Rothman, D. L., Li, B., & Peng, L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00025 · Cited by 66 · see citing works

Expression of serotonin receptors in human fetal astrocytes and glioma cell lines: a possible role in glioma cell proliferation and migration

Merzak, A., Koochekpour, S., Fillion, M., et al. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00058-7 · Cited by 65 · see citing works

Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia

Hisaoka‐Nakashima, K., Kajitani, N., Kaneko, M., Shigetou, T., Kasai, M., Matsumoto, C., Yokoe, T., Azuma, H., Takebayashi, M., Morioka, N., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2015.12.057 · Cited by 65 · see citing works

Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-γ as astroglial targets of lithium

Rivera, A. D., & Butt, A. M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0542-2 · Cited by 64 · see citing works

Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH

Fu, H., Li, B., Hertz, L., & Peng, L. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.04.010 · Cited by 63 · see citing works

The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism

Betry, C., Pehrson, A. L., Etiévant, A., Ebert, B., Sánchez, C., & Haddjeri, N. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001058 · Cited by 62 · see citing works

Serotonin 2C Receptors: Suicide, Serotonin, and Runaway RNA Editing

Schmauss, C. (2003) · The Neuroscientist · doi:10.1177/1073858403253669 · Cited by 62 · see citing works

The absence of 5-HT4 receptors modulates depression- and anxiety-like responses and influences the response of fluoxetine in olfactory bulbectomised mice: Adaptive changes in hippocampal neuroplasticity markers and 5-HT1A autoreceptor

Amigó, J., Díaz, Á., Pilar-Cuéllar, F., Vidal, R., Martín, A., Compan, V., Pazos, Á., & Castro, E. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.037 · Cited by 62 · see citing works

Thirty Years of Clinical Experience with Carbamazepine in the Treatment of Bipolar Illness

Post, R. M., Ketter, T. A., Uhde, T. W., & Ballenger, J. C. (2007) · CNS Drugs · doi:10.2165/00023210-200721010-00005 · Cited by 59 · see citing works

Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats

Yamauchi, M., Tatebayashi, T., Nagase, K., Kojima, M., & Imanishi, T. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.05.003 · Cited by 58 · see citing works

Cell Type-Specific Gene Expression and Editing Responses to Chronic Fluoxetine Treatment in the In Vivo Mouse Brain and Their Relevance for Stress-Induced Anhedonia

Li, B., Dong, L., Wang, B., Cai, L., Jiang, N., & Peng, L. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0814-1 · Cited by 58 · see citing works

Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects

Peng, L., Gu, L., Li, B., & Hertz, L. (2014) · Current Neuropharmacology · doi:10.2174/1570159x12666140828221720 · Cited by 58 · see citing works

Familial Risk for Major Depression is Associated with Lower Striatal 5-HT4 Receptor Binding

Madsen, K. S., Torstensen, E. W., Holst, K. K., Haahr, M. E., Knorr, U. B., Frøkjær, V. G., Brandt-Larsen, M., Iversen, P., Fisher, P. M., & Knudsen, G. M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu034 · Cited by 58 · see citing works

Novel treatment options in depression and psychosis

Češková, E., & Šilhán, P. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s157475 · Cited by 56 · see citing works

5‐HT1B autoreceptor regulation of serotonin transporter activity in synaptosomes

Hagan, C. E., McDevitt, R. A., Liu, Y. K., Furay, A. R., & Neumaier, J. F. (2012) · Synapse · doi:10.1002/syn.21608 · Cited by 55 · see citing works

Mice lacking the serotonin 5-HT 2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants

Diaz, S. L., Narboux‐Nême, N., Boutourlinsky, K., Doly, S., & Maroteaux, L. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.012 · Cited by 55 · see citing works

Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice

Xia, M., Li, Z., Li, S., Liang, S., Li, X., Chen, B., Zhang, M., Dong, C., Verkhratsky, A., Guan, D., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00524-4 · Cited by 55 · see citing works

Fluoxetine affects GluK2 editing, glutamate-evoked Ca2+ influx and extracellular signal-regulated kinase phosphorylation in mouse astrocytes

Li, B., Zhang, S., Zhang, H., Hertz, L., & Peng, L. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100094 · Cited by 54 · see citing works

5-HT1A, 5-HT2A, and 5-HT2C receptor mRNA modulation by antidepressant treatment in the chronic mild stress model of depression: sex differences exposed

Pitychoutis, P. M., Dalla, C., Sideris, A. C., Tsonis, P. A., & Papadopoulou‐Daifoti, Z. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.003 · Cited by 54 · see citing works

Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand.

Bonaventure, P., Schotte, A., Cras, P. P., et al. (1997) · PubMed · Cited by 54 · see citing works

Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation

Li, X., Liang, S., Li, Z., Li, S., Xia, M., Verkhratsky, A., & Li, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00734 · Cited by 54 · cited 13× · see citing works

The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation

Xia, M., Li, X., Yang, L., Ren, J., Sun, G., Qi, S., Verkhratsky, A., & Li, B. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14272 · Cited by 53 · see citing works

Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation

Li, B., Zhang, S., Li, M., Hertz, L., & Peng, L. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1631-3 · Cited by 52 · see citing works

Effects of Monoamines and Antidepressants on Astrocyte Physiology: Implications for Monoamine Hypothesis of Depression

Marathe, S., D’almeida, P. L., Virmani, G., Bathini, P., & Alberi, L. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518789149 · Cited by 52 · see citing works

A longitudinal fMRI study of the manic and euthymic states of bipolar disorder

Chen, C., John Suckling, A., Ooi, C., Jacob, R., Lupson, V. C., Bullmore, E. T., & Lennox, B. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00801.x · Cited by 51 · see citing works

Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

Borroto‐Escuela, D. O., Narváez, M., Ambrogini, P., Ferraro, L., Brito, I., Romero‐Fernandez, W., Andrade‐Talavera, Y., Flores‐Burgess, A., Millón, C., Gago, B., et al. (2018) · Molecules · doi:10.3390/molecules23061341 · Cited by 50 · see citing works

The 5-HT3 receptor agonist attenuates the action of antidepressants in the forced swim test in rats

Nakagawa, Y., Ishima, T., & Takashima, T. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01459-5 · Cited by 49 · see citing works

The origin of myo‐inositol in brain, cerebrospinal fluid and choroid plexus

Spector, R., & Lorenzo, A. V. (1975) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1975.tb06980.x · Cited by 49 · see citing works

Help-seeking intentions and subsequent 12-month mental health service use in Chinese primary care patients with depressive symptoms

Chin, W. Y., Chan, K. T. Y., Lam, C. L. K., Lam, T. P., & Wan, E. Y. F. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006730 · Cited by 49 · see citing works

Inositol depletion, GSK3 inhibition and bipolar disorder

Yu, W., & Greenberg, M. L. (2016) · Future Neurology · doi:10.2217/fnl-2016-0003 · Cited by 49 · see citing works

Astrocytes in rapid ketamine antidepressant action

Stenovec, M., Li, B., Verkhratsky, A., & Zorec, R. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108158 · Cited by 47 · see citing works

Altered serotonin 2C receptor RNA splicing in suicide: association with editing

Dracheva, S. M., Chin, B., & Haroutunian, V. H. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3282f556d2 · Cited by 46 · see citing works

Review of the use of mirtazapine in the treatment of depression

Benjamin, S., & Doraiswamy, P. M. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.585459 · Cited by 46 · see citing works

Targeting astrocytes in bipolar disorder

Peng, L., Li, B., & Verkhratsky, A. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1171144 · Cited by 46 · see citing works

Role of glial cell line-derived neurotrophic factor in the pathogenesis and treatment of mood disorders

Tsybko, A. S., Ilchibaeva, T. V., & Popova, N. K. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0063 · Cited by 46 · see citing works

Behavioral Pharmacology of AR-A000002, a Novel, Selective 5-Hydroxytryptamine1B Antagonist

Hudzik, T. J., Yanek, M., Porrey, T., Evenden, J. L., Paronis, C. A., Mastrangelo, M., Ryan, C. N., Ross, S. B., & Stenfors, C. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.045468 · Cited by 44 · see citing works

Modulation of cholinergic functions by serotonin and possible implications in memory: General data and focus on 5-HT1A receptors of the medial septum

Jeltsch‐David, H., Koenig, J., & Cassel, J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.037 · Cited by 43 · see citing works

The highly selective 5‐hydroxytryptamine (5‐HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test

Patel, J. G., Bartoszyk, G. D., Edwards, E., & Ashby, C. R. (2004) · Synapse · doi:10.1002/syn.10308 · Cited by 43 · see citing works

Desvenlafaxine prevents white matter injury and improves the decreased phosphorylation of the rate‐limiting enzyme of cholesterol synthesis in a chronic mouse model of depression

Wang, J., Qiao, J., Zhang, Y., Wang, H., Zhu, S., Zhang, H., Hartle, K., Guo, H., Guo, W., He, J., et al. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12792 · Cited by 43 · see citing works

Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations

Wolfson, M., Bersudsky, Y., Zinger, E., Simkin, M., Belmaker, R. H., & Hertz, L. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02371-9 · Cited by 42 · see citing works

Major depressive disorder: hypothesis, mechanism, prevention and treatment

Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,061 · see citing works