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Cited by 93Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Microglia‐dependent remodeling of neuronal circuits

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Guedes, Joana R., Ferreira, Pedro A., Costa, Jéssica M., Cardoso, Ana L., Peça, João·2022·Journal of Neurochemistry
DOI 10.1111/jnc.15689PMC PMC9826178
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Abstract

Microglia are tissue‐resident macrophages responsible for the surveillance, neuronal support, and immune defense of the brain parenchyma. Recently, the role played by microglia in the formation and function of neuronal circuits has garnered substantial attention. During development, microglia have been shown to engulf neuronal precursors and participate in pruning mechanisms while, in the mature brain, they influence synaptic signaling, provide trophic support and shape synaptic plasticity. Recently, studies have unveiled different microglial characteristics associated with specific brain regions. This emerging view suggests that the maturation and function of distinct neuronal circuits may be potentially associated with the molecular identity microglia adopts across the brain. Here, we review and summarize the known role of these cells in the thalamus, hippocampus, cortex, and cerebellum. We focus on in vivo studies to highlight the characteristics of microglia that may be important in the remodeling of these neuronal circuits and in relation to neurodevelopmental and neuropsychiatric disorders.image

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Cited by

Sorted by citations

Authors
Guedes, J. R., Ferreira, P. A., Costa, J. M., Cardoso, A. L., & Peça, J.
Affiliations
Centro de Neurociências e Biologia Celular (PT)
Corresponding author
Peça, João
ORCID
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2022-09-05
Volume
163
Issue
2
Pages
74-93
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
DOI
10.1111/jnc.15689
PMC
PMC9826178
OpenAlex
W4290804426
Cited by
93
References
36
Citations by year
2026: 22 · 2025: 26 · 2024: 23 · 2023: 19 · 2022: 3
FWCI
2.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neurochemistry (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Fundação para a Ciência e a Tecnologia (PTDC/MED‐NEU/5993/2020)
  • Fundação Bial
  • Brain and Behavior Research Foundation
  • European Regional Development Fund
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
microglia, synaptic pruning, synaptic plasticity, microglial heterogeneity, thalamus, hippocampus, cerebral cortex, cerebellum, neurodevelopmental disorders, neuropsychiatric disorders
MeSH terms
Brain, Hippocampus, Neuronal Plasticity, Neurons, Synapses, Microglia

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