Cited by 50Hypothalamic control of reproductive hormonesNeurogenesis and neuroplasticity mechanismsNeuroendocrine regulation and behavior

Development of the gonadotropin‐releasing hormone system

Open access
Duittoz, Anne H., Forni, Paolo E., Giacobini, Paolo, Golan, Matan, Mollard, Patrice, Negrón, Ariel L., Radovick, Sally, Wray, Susan·2022·Journal of Neuroendocrinology

Abstract

This review summarizes the current understanding of the development of the neuroendocrine gonadotropin‐releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

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Crossref · 10.1111/jne.13087

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  • The HY Gnrh1 Glut class is the hypothalamic Gnrh1 neuronal type developmentally originated from the embryonic olfactory epithelium.

    “The HY Gnrh1 Glut class is the hypothalamic Gnrh1 neuronal type developmentally originated from the embryonic olfactory epithelium39.”

    From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [39]

    The Introduction and “Olfactory placode and GnRH ontogenesis” section report that GnRH neurons arise in the developing olfactory region and migrate into the forebrain. The paper places their origin in the olfactory placode, likely near the vomeronasal organ primordium, rather than specifically in the olfactory epithelium. It does not identify an “HY Gnrh1 Glut” class or establish that class’s developmental origin; page numbers were not available in our copy. (LLM, conf=0.86)

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Authors
Duittoz, A. H., Forni, P. E., Giacobini, P., Golan, M., Mollard, P., Negrón, A. L., Radovick, S., & Wray, S.
Affiliations
  • Université de Tours (FR)
  • University at Albany, State University of New York (US)
  • Inserm (FR)
  • Agricultural Research Organization (IL)
  • Centre National de la Recherche Scientifique (FR)
  • Rutgers, The State University of New Jersey (US)
  • National Institutes of Health (US)
Corresponding author
Wray, Susan
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2022-01-23
Volume
34
Issue
5
Pages
e13087-e13087
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
OpenAlex
W4200526272
Cited by
50
References
114
Citations by year
2026: 9 · 2025: 13 · 2024: 9 · 2023: 15 · 2022: 3 · 2021: 1
FWCI
1.15
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroendocrinology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
Funders
  • Agence Nationale de la Recherche (ANR‐ 15‐CE14‐0012, ANR‐18‐CE14‐0017)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD068777)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
gonadotropin-releasing hormone, prenatal development, GnRH neurons, neuronal migration, paracrine signaling, synaptic transmission, neuroendocrine regulation, rodents, human
MeSH terms
Female, Gene Expression Regulation, Humans, Gonadotropin-Releasing Hormone, Neurons, Neurosecretory Systems, Pregnancy

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