Development of the gonadotropin‐releasing hormone system
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This review summarizes the current understanding of the development of the neuroendocrine gonadotropin‐releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.
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The HY Gnrh1 Glut class is the hypothalamic Gnrh1 neuronal type developmentally originated from the embryonic olfactory epithelium.
“The HY Gnrh1 Glut class is the hypothalamic Gnrh1 neuronal type developmentally originated from the embryonic olfactory epithelium39.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [39]
The Introduction and “Olfactory placode and GnRH ontogenesis” section report that GnRH neurons arise in the developing olfactory region and migrate into the forebrain. The paper places their origin in the olfactory placode, likely near the vomeronasal organ primordium, rather than specifically in the olfactory epithelium. It does not identify an “HY Gnrh1 Glut” class or establish that class’s developmental origin; page numbers were not available in our copy. (LLM, conf=0.86)
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Identifying Isl1 Genetic Lineage in the Developing Olfactory System and in GnRH-1 Neurons
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A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,194 · see citing works
- Authors
- Duittoz, A. H., Forni, P. E., Giacobini, P., Golan, M., Mollard, P., Negrón, A. L., Radovick, S., & Wray, S.
- Affiliations
- Université de Tours (FR)
- University at Albany, State University of New York (US)
- Inserm (FR)
- Agricultural Research Organization (IL)
- Centre National de la Recherche Scientifique (FR)
- Rutgers, The State University of New Jersey (US)
- National Institutes of Health (US)
- Corresponding author
- Wray, Susan
- ORCID
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2022-01-23
- Volume
- 34
- Issue
- 5
- Pages
- e13087-e13087
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- PMC
- PMC9286803
- OpenAlex
- W4200526272
- Cited by
- 50
- References
- 114
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 9 · 2023: 15 · 2022: 3 · 2021: 1
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroendocrinology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- Agence Nationale de la Recherche (ANR‐ 15‐CE14‐0012, ANR‐18‐CE14‐0017)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD068777)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- gonadotropin-releasing hormone, prenatal development, GnRH neurons, neuronal migration, paracrine signaling, synaptic transmission, neuroendocrine regulation, rodents, human
- MeSH terms
- Female, Gene Expression Regulation, Humans, Gonadotropin-Releasing Hormone, Neurons, Neurosecretory Systems, Pregnancy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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