The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)
Open accessAbstract
The mammalian reproductive hormone axis regulates gonadal steroid hormone levels and gonadal function essential for reproduction. The neuroendocrine control of the axis integrates signals from a wide array of inputs. The regulatory pathways important for mediating these inputs have been the subject of numerous studies. One class of proteins that have been shown to mediate metabolic and growth signals to the CNS includes Insulin and IGF-1. These proteins are structurally related and can exert endocrine and growth factor like action via related receptor tyrosine kinases. The role that insulin and IGF-1 play in controlling the hypothalamus and pituitary and their role in regulating puberty and nutritional control of reproduction has been studied extensively. This review summarizes the in vitro and in vivo models that have been used to study these neuroendocrine structures and the influence of these growth factors on neuroendocrine control of reproduction.
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IGF-1 is structurally homologous to insulin and findings suggest that it is also involved in GnRH regulation.
“IGF-1 is structurally homologous to insulin and findings suggest that it is also involved in GnRH regulation.108”
From Pubertal development and regulation (2016) · cites this paper as [108]
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Cited by
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Pubertal development and regulation
Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611 · see citing works
Parent, A.-S., Franssen, D., Fudvoye, J., Gérard, A., & Bourguignon, J.-P. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.12.004 · Cited by 175 · see citing works
Development of the gonadotropin‐releasing hormone system
Duittoz, A. H., Forni, P. E., Giacobini, P., Golan, M., Mollard, P., Negrón, A. L., Radovick, S., & Wray, S. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13087 · Cited by 50 · see citing works
- Authors
- Wolfe, A., Divall, S., & Wu, S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Wolfe, Andrew
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 35
- Issue
- 4
- Pages
- 558-572
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC4175134
- OpenAlex
- W2076110825
- Cited by
- 83
- References
- 311
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 3 · 2014: 2
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD068777, K99HD068130, K08HD056139, R01HD044608, R00HD068130)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- insulin, insulin-like growth factor I, neuroendocrine regulation of reproduction, hypothalamus, pituitary gland, gonadotropin secretion, puberty, growth factor signaling, receptor tyrosine kinase, sex steroids
- MeSH terms
- Animals, Humans, Insulin, Insulin-Like Growth Factor I, Neurosecretory Systems, Pituitary Gland, Reproduction, Sexual Maturation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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