Cited by 83Hypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth FactorsRegulation of Appetite and Obesity

The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)

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Wolfe, Andrew, Divall, Sara, Wu, Sheng·2014·Frontiers in Neuroendocrinology

Abstract

The mammalian reproductive hormone axis regulates gonadal steroid hormone levels and gonadal function essential for reproduction. The neuroendocrine control of the axis integrates signals from a wide array of inputs. The regulatory pathways important for mediating these inputs have been the subject of numerous studies. One class of proteins that have been shown to mediate metabolic and growth signals to the CNS includes Insulin and IGF-1. These proteins are structurally related and can exert endocrine and growth factor like action via related receptor tyrosine kinases. The role that insulin and IGF-1 play in controlling the hypothalamus and pituitary and their role in regulating puberty and nutritional control of reproduction has been studied extensively. This review summarizes the in vitro and in vivo models that have been used to study these neuroendocrine structures and the influence of these growth factors on neuroendocrine control of reproduction.

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Crossref · 10.1016/j.yfrne.2014.05.007

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  • IGF-1 is structurally homologous to insulin and findings suggest that it is also involved in GnRH regulation.

    “IGF-1 is structurally homologous to insulin and findings suggest that it is also involved in GnRH regulation.108”

    From Pubertal development and regulation (2016) · cites this paper as [108]

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Authors
Wolfe, A., Divall, S., & Wu, S.
Affiliations
Johns Hopkins University (US)
Corresponding author
Wolfe, Andrew
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2014-10
Volume
35
Issue
4
Pages
558-572
ISSN
0091-3022 (ISSN-L)
OpenAlex
W2076110825
Cited by
83
References
311
Citations by year
2026: 7 · 2025: 8 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 3 · 2014: 2
FWCI
1.15
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD068777, K99HD068130, K08HD056139, R01HD044608, R00HD068130)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
insulin, insulin-like growth factor I, neuroendocrine regulation of reproduction, hypothalamus, pituitary gland, gonadotropin secretion, puberty, growth factor signaling, receptor tyrosine kinase, sex steroids
MeSH terms
Animals, Humans, Insulin, Insulin-Like Growth Factor I, Neurosecretory Systems, Pituitary Gland, Reproduction, Sexual Maturation

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