Calcium Signaling in Neuronal Motility
Abstract
Neuronal motility is a fundamental feature that underlies the development, regeneration, and plasticity of the nervous system. Two major developmental events—directed migration of neuronal precursor cells to the proper positions and guided elongation of axons to their target cells—depend on large-scale neuronal motility. At a finer scale, motility is also manifested in many aspects of neuronal structures and functions, ranging from differentiation and refinement of axonal and dendritic morphology during development to synapse remodeling associated with learning and memory in the adult brain. As a primary second messenger that conveys the cytoplasmic actions of electrical activity and many neuroactive ligands, Ca 2+ plays a central role in the regulation of neuronal motility. Recent studies have revealed common Ca 2+-dependent signaling pathways that are deployed for regulating cytoskeletal dynamics associated with neuronal migration, axon and dendrite development and regeneration, and synaptic plasticity.
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Cytosolic calcium plays a critical role in controlling axonal and dendritic growth and arborization.
“Cytosolic calcium plays a critical role in controlling axonal and dendritic growth and arborization75–79.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [76]
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- Authors
- Zheng, J. Q., & Poo, M.-M.
- Affiliations
- University of Medicine and Dentistry of New Jersey (US)
- University of California, Berkeley (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2007-11-01
- Volume
- 23
- Issue
- 1
- Pages
- 375-404
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2106768378
- Cited by
- 292
- References
- 16
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 3 · 2023: 9 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 14 · 2016: 13 · 2015: 17 · 2014: 15 · 2013: 26 · 2012: 31
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM083889)
- National Institute of Neurological Disorders and Stroke (R01NS022764, NS22764, NS036241)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- calcium signaling, neuronal motility, neuronal migration, axon guidance, dendrite formation, axon regeneration, synaptic remodeling, synaptic plasticity, cytoskeletal dynamics, second messengers, brain development
- MeSH terms
- Animals, Axons, Cell Movement, Humans, Neurons, Regeneration, Synapses, Neurites, Calcium Signaling, Growth Cones
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