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Cited by 32Curcumin's Biomedical ApplicationsSkin Protection and AgingMedicinal Plant Research

Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double‐blind, placebo‐controlled trial

Asada, Kazuki, Ohara, Tatsuya, Muroyama, Koutarou, Yamamoto, Yoshihiro, Murosaki, Shinji·2019·Journal of Cosmetic Dermatology
DOI 10.1111/jocd.12890
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Abstract

BACKGROUND: Curcuma longa has been reported to have anti-inflammatory effects. Skin inflammation impairs skin functions. OBJECTIVES: Our aim was to investigate the effect of a hot water extract of C longa (WEC) on skin conditions in cell studies using keratinocytes and in clinical trials. METHODS: We measured proinflammatory cytokine levels in ultraviolet B-irradiated keratinocytes in the presence or absence of WEC. The effects of WEC on hyaluronan production in keratinocytes were also determined. In a randomized, double-blind, placebo-controlled trial, 47 healthy participants were assigned to 8-week intervention groups with daily intakes of WEC with or without curcumin or a placebo. The water content and transepidermal water loss in the face and minimal erythema dose on the back after ultraviolet B irradiation were evaluated every 4 weeks. RESULTS: Hot water extract of C longa significantly inhibited increases in ultraviolet B-induced tumor necrosis factor α and interleukin 1β at the mRNA and protein levels. WEC also significantly increased hyaluronan production from nonstimulated keratinocytes. In the randomized, double-blind, placebo-controlled trial, increases from baseline in the water content of the face were significantly greater at weeks 4 and 8 in the WEC group, but not in the WEC + curcumin group, than in the placebo group. There were no significant differences in transepidermal water loss and minimal erythema dose among the groups. CONCLUSIONS: The cell studies confirmed that WEC has anti-inflammatory effects and augments hyaluronan production in the skin. The results of clinical trials suggest that WEC may be useful for moisturizing facial skin. TRIAL REGISTRATION: UMIN Clinical Trials Registry 000028510. Retrospectively registered.

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  • In a randomized double-blind placebo-controlled trial, oral supplementation with curcumin improved moisture content of facial skin and inhibited increases in UVB-induced tumor necrosis factor-alpha and IL-1 in skin.

    “In this randomized, double-blind, placebo-controlled trial, oral supplementation with curcumin improved the moisture content of facial skin and inhibited increases in UVB-induced tumor necrosis factor-α and IL-1 in skin [111].”

    From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [111]

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Authors
Asada, K., Ohara, T., Muroyama, K., Yamamoto, Y., & Murosaki, S.
Affiliations
House Wellness Foods Corporation (Japan) (JP)
Corresponding author
Asada, Kazuki
ORCID
Venue
Journal of Cosmetic Dermatology
Publisher
Wiley
Published
2019-02-27
Volume
18
Issue
6
Pages
1866-1874
ISSN
  • 1473-2130 (ISSN-L)
  • 1473-2165
DOI
10.1111/jocd.12890
OpenAlex
W2917925043
Cited by
32
References
41
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 1
FWCI
0.95
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Cosmetic Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
House Wellness Foods Corporation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
turmeric, human epidermal keratinocytes, skin inflammation, UVB irradiation, inflammatory cytokines, TNF-α, IL-1β, hyaluronan synthesis, transepidermal water loss, minimal erythema dose, curcumin
MeSH terms
Adult, Cells, Cultured, Double-Blind Method, Female, Hot Temperature, Humans, Male, Phytotherapy, Middle Aged, Plant Extracts, Skin Diseases, Ultraviolet Rays, Water, Keratinocytes, Curcuma

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