The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID‐19 patients in Michigan, United States
Open accessAbstract
Introduction: Higher comorbidity and older age have been reported as correlates of poor outcomes in COVID‐19 patients worldwide; however, US data are scarce. We evaluated mortality predictors of COVID‐19 in a large cohort of hospitalized patients in the United States. Design: Retrospective, multicenter cohort of inpatients diagnosed with COVID‐19 by RT‐PCR from 1 March to 17 April 2020 was performed, and outcome data evaluated from 1 March to 17 April 2020. Measures included demographics, comorbidities, clinical presentation, laboratory values and imaging on admission. Primary outcome was mortality. Secondary outcomes included length of stay, time to death and development of acute kidney injury in the first 48‐h. Results: The 1305 patients were hospitalized during the evaluation period. Mean age was 61.0 ± 16.3, 53.8% were male and 66.1% African American. Mean BMI was 33.2 ± 8.8 kg m−2. Median Charlson Comorbidity Index (CCI) was 2 (1–4), and 72.6% of patients had at least one comorbidity, with hypertension (56.2%) and diabetes mellitus (30.1%) being the most prevalent. ACE‐I/ARB use and NSAIDs use were widely prevalent (43.3% and 35.7%, respectively). Mortality occurred in 200 (15.3%) of patients with median time of 10 (6–14) days. Age > 60 (aOR: 1.93, 95% CI: 1.26–2.94) and CCI > 3 (aOR: 2.71, 95% CI: 1.85–3.97) were independently associated with mortality by multivariate analyses. NSAIDs and ACE‐I/ARB use had no significant effects on renal failure in the first 48 h. Conclusion: Advanced age and an increasing number of comorbidities are independent predictors of in‐hospital mortality for COVID‐19 patients. NSAIDs and ACE‐I/ARB use prior to admission is not associated with renal failure or increased mortality.
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COVID-19 mortality risk for older men and women
Yanez, N. D., Weiss, N. S., Romand, J.-A., & Treggiari, M. M. (2020) · BMC Public Health · doi:10.1186/s12889-020-09826-8 · Cited by 616
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Caldeira, D., Alves, M., Gouveia e Melo, R., Silvério António, P., Cunha, N., Nunes-Ferreira, A., Prada, L., Costa, J., & Pinto, F. J. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2020.100627 · Cited by 35
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Metadata
- Authors
- Imam, Z., Odish, F., Gill, I., O’Connor, D., Armstrong, J., Vanood, A., Ibironke, O., Hanna, A., Ranski, A., & Halalau, A.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2020-06-22
- Volume
- 288
- Issue
- 4
- Pages
- 469-476
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W3033710942
- Cited by
- 369
- References
- 15
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Imam, Z., Odish, F., Gill, I., O’Connor, D., Armstrong, J., Vanood, A., Ibironke, O., Hanna, A., Ranski, A., & Halalau, A. (2020). Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID‐19 patients in Michigan, United States. Journal of Internal Medicine. https://doi.org/10.1111/joim.13119
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