COVID-19 mortality risk for older men and women
Open accessAbstract
Background: Case-fatality from COVID-19 has been reported to be relatively high in patients age 65 years or older. We sought to determine the age-specific rates of COVID-19 mortality at the population level. Methods: We obtained information regarding the total number of COVID-19 reported deaths for six consecutive weeks beginning at the 50th recorded death, among 16 countries that reported a relatively high number of COVID-19 cases as of April 12, 2020. We performed an ecological study to model COVID-19 mortality rates per week by age group (54 years or younger, 55–64 years, and 65 years or older) and sex using a Poisson mixed effects regression model. Results: Over the six-week period of data, there were 178,568 COVID-19 deaths from a total population of approximately 2.4 billion people. Age and sex were associated with COVID-19 mortality. Compared with individuals ages 54 years or younger, the incident rate ratio (IRR) was 8.1, indicating that the mortality rate of COVID-19 was 8.1 times higher (95%CI = 7.7, 8.5) among those 55 to 64 years, and more than 62 times higher (IRR = 62.1; 95%CI = 59.7, 64.7) among those ages 65 or older. Mortality rates from COVID-19 were 77% higher in men than in women (IRR = 1.77, 95%CI = 1.74, 1.79). Conclusions: In the 16 countries examined, persons age 65 years or older had strikingly higher COVID-19 mortality rates compared to younger individuals, and men had a higher risk of COVID-19 death than women.
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COVID-19 is reported to be 62 times more fatal in patients older than 65 than in younger patients.
“COVID-19 is reported to be 62 times more fatal in patients older than 65 than it is in younger patients233.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [233]
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- Authors
- Yanez, N. D., Weiss, N. S., Romand, J.-A., & Treggiari, M. M.
- Affiliations
- Yale University (US)
- University of Washington (US)
- Canton of Geneva (CH)
- Corresponding author
- Yanez, N. David
- Venue
- BMC Public Health
- Published
- 2020-11-19
- Volume
- 20
- Issue
- 1
- Pages
- 1742-1742
- ISSN
- 1471-2458 (ISSN-L)
- PMC
- PMC7675386
- OpenAlex
- W3104041940
- Cited by
- 616
- References
- 13
- Citations by year
- 2026: 17 · 2025: 37 · 2024: 98 · 2023: 113 · 2022: 191 · 2021: 155 · 2020: 5
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (UL1TR001863)
- National Center for Advancing Translational Sciences
- Topics
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, COVID-19 mortality, age-specific mortality, sex differences, older adults, men, case fatality
- MeSH terms
- COVID-19, Aged, Female, Humans, Male, Middle Aged, Mortality, Pneumonia, Viral, Risk, Global Health, Age Distribution, Sex Distribution, Coronavirus Infections, Pandemics
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