The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Melatonin prevents obesity through modulation of gut microbiota in mice
Abstract
Excess weight and obesity are severe public health threats worldwide. Recent evidence demonstrates that gut microbiota dysbiosis contributes to obesity and its comorbidities. The body weight‐reducing and energy balancing effects of melatonin have been reported in several studies, but to date, no investigations toward examining whether the beneficial effects of melatonin are associated with gut microbiota have been carried out. In this study, we show that melatonin reduces body weight, liver steatosis, and low‐grade inflammation as well as improving insulin resistance in high fat diet (HFD)‐fed mice. High‐throughput pyrosequencing of the 16S rRNA demonstrated that melatonin treatment significantly changed the composition of the gut microbiota in mice fed an HFD. The richness and diversity of gut microbiota were notably decreased by melatonin. HFD feeding altered 69 operational taxonomic units (OTU s) compare with a normal chow diet (NCD) group, and melatonin supplementation reversed 14 OTU s to the same configuration than those present in the NCD group, thereby impacting various functions, in particular through its ability to decrease the Firmicutes‐to‐Bacteroidetes ratio and increase the abundance of mucin‐degrading bacteria Akkermansia, which is associated with healthy mucosa. Taken together, our results suggest that melatonin may be used as a probiotic agent to reverse HFD‐induced gut microbiota dysbiosis and help us to gain a better understanding of the mechanisms governing the various melatonin beneficial effects.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Different animal studies emphasize the beneficial effects of melatonin in the obesity management. 13-17”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [17]
In the citing paper
“Growing evidence showed that melatonin supplementation decreased weight in animals. 17,36-38”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [17]
Citations
Cites
2 retracted
Chuffa, L. G. D. A., Fioruci-Fontanelli, B. A., Mendes, L. D. O., Seiva, F. R. F., Martinez, M., Fávaro, W. J., Domeniconi, R. F., Pinheiro, P. F. F., dos Santos, L. D., & Martinez, F. E. (2015) · BMC Cancer · doi:10.1186/s12885-015-1032-4 · Cited by 100
RetractedAlonso-Chamorro, M., Collado, P. S., & González‐Gallego, J. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00323.x · Cited by 86
RetractedQIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
FLASH: fast length adjustment of short reads to improve genome assemblies
Magoč, T., & Salzberg, S. L. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr507 · Cited by 15,366
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Research works printed but not linked: 1
- Sajan MP, 2008, Activation of sterol receptor element binding protein‐1c and nfkb by atypical protein kinase c in liver mediates lipid abnormalities and insulin resistance in murine obesity models, Diabetes, 57, A376
Cited by
Sorted by citations
Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas
Reiter, R. J., Rosales-Corral, S., Tan, D. X., Jou, M. J., Galano, A., & Xu, B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2609-7 · Cited by 558
Probiotics improve gut microbiota dysbiosis in obese mice fed a high-fat or high-sucrose diet
Kong, C., Gao, R., Yan, X., Huang, L., & Qin, H. (2018) · Nutrition · doi:10.1016/j.nut.2018.10.002 · Cited by 497
Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice
Yin, J., Li, Y., Han, H. L., Chen, S., Gao, J., Liu, G., Wu, X., Deng, J., Yu, Q., Huang, X., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12524 · Cited by 387
Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice
Wang, P., Li, D., Ke, W., Liang, D., Hu, X., & Chen, F. (2020) · International Journal of Obesity · doi:10.1038/s41366-019-0332-1 · Cited by 301
Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice
Gao, T., Wang, Z., Dong, Y., Cao, J., Lin, R., Wang, X., Yu, Z., & Chen, Y. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12574 · Cited by 301
Metadata
- Authors
- Xu, P., Wang, J., Hong, F., Wang, S., Jin, X., Xue, T., Jia, L., & Zhai, Y.
- Affiliations
- Beijing Normal University (CN)
- Beijing Key Laboratory of Gene Resource and Molecular Development College of Life Sciences Beijing Normal University Beijing China
- Corresponding author
- Zhai, Yonggong
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2017-03-10
- Volume
- 62
- Issue
- 4
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2587996254
- Cited by
- 281
- References
- 65
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 28 · 2023: 36 · 2022: 48 · 2021: 51 · 2020: 36 · 2019: 27 · 2018: 21 · 2017: 8
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31571164, 31271207)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- melatonin, obesity, gut microbiota, dysbiosis, high-fat diet, body weight, hepatic steatosis, insulin resistance, low-grade inflammation, Akkermansia, Firmicutes/Bacteroidetes ratio, mucin-degrading bacteria, probiotics
- MeSH terms
- Firmicutes, Bacillota, Gastrointestinal Microbiome, Animals, Central Nervous System Depressants, Fatty Liver, Inflammation, Insulin Resistance, Male, Melatonin, Mice, Inbred C57BL, Obesity, Blotting, Western, Weight Gain, Glucose Intolerance, Probiotics, Bacteroidetes, Mice, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
