Cited by 282Gut microbiota and healthCircadian rhythm and melatoninRegulation of Appetite and Obesity

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Melatonin prevents obesity through modulation of gut microbiota in mice

Xu, Pengfei, Wang, Jialin, Hong, Fan, Wang, Sheng, Jin, Xi, Xue, Tingting, Jia, Li, Zhai, Yonggong·2017·Journal of Pineal Research

DOI 10.1111/jpi.12399

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Abstract

Excess weight and obesity are severe public health threats worldwide. Recent evidence demonstrates that gut microbiota dysbiosis contributes to obesity and its comorbidities. The body weight‐reducing and energy balancing effects of melatonin have been reported in several studies, but to date, no investigations toward examining whether the beneficial effects of melatonin are associated with gut microbiota have been carried out. In this study, we show that melatonin reduces body weight, liver steatosis, and low‐grade inflammation as well as improving insulin resistance in high fat diet (HFD)‐fed mice. High‐throughput pyrosequencing of the 16S rRNA demonstrated that melatonin treatment significantly changed the composition of the gut microbiota in mice fed an HFD. The richness and diversity of gut microbiota were notably decreased by melatonin. HFD feeding altered 69 operational taxonomic units (OTU s) compare with a normal chow diet (NCD) group, and melatonin supplementation reversed 14 OTU s to the same configuration than those present in the NCD group, thereby impacting various functions, in particular through its ability to decrease the Firmicutes‐to‐Bacteroidetes ratio and increase the abundance of mucin‐degrading bacteria Akkermansia, which is associated with healthy mucosa. Taken together, our results suggest that melatonin may be used as a probiotic agent to reverse HFD‐induced gut microbiota dysbiosis and help us to gain a better understanding of the mechanisms governing the various melatonin beneficial effects.

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2 retracted

RETRACTED ARTICLE: Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer
Chuffa, L. G. D. A., Fioruci-Fontanelli, B. A., Mendes, L. D. O., Seiva, F. R. F., Martinez, M., Fávaro, W. J., Domeniconi, R. F., Pinheiro, P. F. F., dos Santos, L. D., & Martinez, F. E. (2015) · BMC Cancer · doi:10.1186/s12885-015-1032-4 · Cited by 100
Retracted
RETRACTED: Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle
Alonso-Chamorro, M., Collado, P. S., & González‐Gallego, J. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00323.x · Cited by 86
Retracted
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
FLASH: fast length adjustment of short reads to improve genome assemblies
Magoč, T., & Salzberg, S. L. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr507 · Cited by 15,366
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915
Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults
Bhaskaran, K., Douglas, I., Forbes, H., dos-Santos-Silva, I., Leon, D. A., & Smeeth, L. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60892-8 · Cited by 1,707
An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
Shin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut · doi:10.1136/gutjnl-2012-303839 · Cited by 1,550
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
Chang, C., Lin, C.-S., Lu, C., Martel, J., Ko, Y., Ojcius, D. M., Tseng, S., Wu, T.-R., Chen, Y. M., Young, J. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms8489 · Cited by 1,254
High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway
Kim, K., Gu, W., Lee, I., Joh, E., & Kim, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047713 · Cited by 1,228
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180
Global burden of cancer attributable to high body-mass index in 2012: a population-based study
Arnold, M., Pandeya, N., Byrnes, G. B., Renehan, A. G., Stevens, G. A., Ezzati, M., Ferlay, J., Miranda, J. J., Romieu, I., Dikshit, R. P., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)71123-4 · Cited by 997
National, regional, and global trends in adult overweight and obesity prevalences
Stevens, G. A., Singh, G. M., Lu, Y., Danaei, G., Lin, J. K., Finucane, M. M., Bahalim, A. N., McIntire, R. K., Gutierrez, H. R., Cowan, M. J., et al. (2012) · Population Health Metrics · doi:10.1186/1478-7954-10-22 · Cited by 967
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.026 · Cited by 960
Functions of melatonin in plants: a review
Arnao, M. B., & Hernández‐Ruíz, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12253 · Cited by 905
The gut microbiota and obesity: from correlation to causality
Zhao, L. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3089 · Cited by 860
Melatonin, energy metabolism, and obesity: a review
Cipolla‐Neto, J., do Amaral, F. G., Afeche, S. C., Tan, D. X., & Reiter, R. J. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12137 · Cited by 611
Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin
Tan, D., Manchester, L. C., Hardeland, R., López‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02111.x · Cited by 541
Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations
Zhang, C., Zhang, M. H., Pang, X., Zhao, Y., Wang, L., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2012.27 · Cited by 504
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
Schulz, M. D., Atay, Ç., Heringer, J., Romrig, F., Schwitalla, S., Aydın, B., Ziegler, P. K., Varga, J., Reindl, W., Pommerenke, C., et al. (2014) · Nature · doi:10.1038/nature13398 · Cited by 458
Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake.
Thuy, S., Ladurner, R., Volynets, V., Wagner, S., Strahl, S., Königsrainer, A., Maier, K., Bischoff, S., & Bergheim, I. (2008) · Journal of NutriLife · doi:10.1093/jn/138.8.1452 · Cited by 432
Elevated endotoxin levels in non-alcoholic fatty liver disease
Harte, A. L., da Silva, N. F., Creely, S. J., McGee, K. C., Billyard, T., Elabd, E. M. Y., Tripathi, G., Ashour, E., Abdalla, M. S., Sharada, H. M., et al. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-15 · Cited by 406
Microbiota depletion promotes browning of white adipose tissue and reduces obesity
Suárez-Zamorano, N., Fabbiano, S., Chevalier, C., Stojanović, O., Colin, D. J., Stevanović, A., Veyrat-Durebex, C., Tarallo, V., Rigo, D., Germain, S., et al. (2015) · Nature Medicine · doi:10.1038/nm.3994 · Cited by 403
A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome
Xiao, S., Fei, N., Pang, X., Shen, J., Wang, L., Zhang, B., Zhang, M. H., Zhang, X., Zhang, C., Li, M., et al. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12228 · Cited by 376
Self-citation
Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity
Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 353
Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue
Geurts, L., Lazarević, V., Derrien, M., Everard, A., Roye, M. V., Knauf, C., Valet, P., Girard, M., Muccioli, G. G., François, P., et al. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00149 · Cited by 335
Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity
Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281
Photoperiodic Control and Effects of Melatonin on Nonshivering Thermogenesis and Brown Adipose Tissue
Heldmaier, G., Steinlechner, S., Rafael, J., & Vsiansky, P. (1981) · Science · doi:10.1126/science.7233183 · Cited by 233
Pineal hormone melatonin oscillates also in the dinoflagellateGonyaulax polyedra
P�ggeler, B., Balzer, I., Hardeland, R., & Lerchl, A. (1991) · Die Naturwissenschaften · doi:10.1007/bf01134354 · Cited by 228
Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats
Jiménez‐Aranda, A., Fernández‐Vázquez, G., Campos, D., Tassi, M., Velasco‐Perez, L., Tan, D. X., Reiter, R. J., & Agil, A. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12089 · Cited by 193
Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats
Agil, A., Rosado, I., Ruiz, R., Figueroa, A., Zen, N., & Fernández‐Vázquez, G. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00928.x · Cited by 169
Targeting the Microbiota to Address Diet-Induced Obesity: A Time Dependent Challenge
Clarke, S. F., Murphy, E. F., O’Sullivan, Ó., Ross, R. P., O’Toole, P. W., Shanahan, F., & Cotter, P. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065790 · Cited by 169
Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats
Agil, A., Navarro‐Alarcón, M., Ruiz, R., Abuhamdah, S. M. A., El‐Mir, M., & Vázquez, G. F. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00830.x · Cited by 168
Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high fat–fed rats
Ríos-Lugo, M. J., Cano, P., Jiménez‐Ortega, V., Fernández‐Mateos, P., Scacchi, P. A., Cardinali, D. P., & Esquifino, A. I. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00798.x · Cited by 168
Melatonin ameliorates low‐grade inflammation and oxidative stress in young Zucker diabetic fatty rats
Agil, A., Reiter, R. J., Jiménez‐Aranda, A., Arias, R. I., Navarro‐Alarcón, M., Marchal, J. A., Adem, A., & Fernández‐Vázquez, G. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12012 · Cited by 161
Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity
Szewczyk‐Golec, K., Woźniak, A., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12257 · Cited by 153
Chronic melatonin consumption prevents obesity‐related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet‐induced obesity
Nduhirabandi, F., Toit, E. F. D., Blackhurst, D., MARAIS, D. P., & Lochner, A. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00826.x · Cited by 144
Duration of Adulthood Overweight, Obesity, and Cancer Risk in the Women’s Health Initiative: A Longitudinal Study from the United States
Arnold, M., Jiang, L., Stefanick, M. L., Johnson, K., Lane, D. S., LeBlanc, E. S., Prentice, R. L., Rohan, T. E., Snively, B. M., Vitolins, M. Z., et al. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002081 · Cited by 140
Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF‐kB and apoptosis after experimental kidney transplantation
Li, Z., Nickkholgh, A., Yi, X., Bruns, H., Groß, M.-L., Hoffmann, K., Mohr, E., Zorn, M., Büchler, M. W., & Schemmer, P. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00672.x · Cited by 136
Melatonin stimulates Growth of Brown Adipose Tissue
Heldmaier, G., & Hoffmann, K. H. (1974) · Nature · doi:10.1038/247224a0 · Cited by 120
Global trends in the prevalence of overweight and obesity
Morgen, C. S., & Sørensen, T. I. A. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.124 · Cited by 117
Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle
Teodoro, B. G., Baraldi, F. G., Sampaio, I. H., Bomfim, L. H. M., Queiroz, A. L., Passos, M. A., Carneiro, E. M., Alberici, L. C., Gomis, R., Amaral, F. G., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12157 · Cited by 106
Melatonin and 5-methoxytryptamine in non-metazoans
Hardeland, R. (1999) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19990311 · Cited by 104
Melatonin improves insulin sensitivity independently of weight loss in old obese rats
Zanuto, R., de Siqueira-Filho, M. A., Caperuto, L. C., Bacurau, R. F. P., Hirata, E., Garcia, R. A. P., do Amaral, F. G., Marçal, A. C., Ribeiro, L. M., Camporez, J. P., et al. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12056 · Cited by 98
Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats
Agil, A., El‐Hammadi, M. M., Jiménez‐Aranda, A., Tassi, M., Abdo, W. S., Fernández‐Vázquez, G., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12241 · Cited by 87
Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders
Xu, P., Hong, F., Wang, J., Cong, Y., Dai, S., Wang, S., Wang, J., Jin, X., Wang, F., Liu, J., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.019 · Cited by 81
Self-citation
Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet‐induced metabolic syndrome in rats
Cano, P., Pagano, E. S., Jiménez‐Ortega, V., Fernández‐Mateos, P., Esquifino, A. I., & Cardinali, D. P. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12168 · Cited by 67
Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice
Chen, X., Zhang, C., Zhao, M., Shi, C.-E., Zhu, R.-M., Wang, H., Zhao, H., Wei, W., Li, J., & Xu, D. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00905.x · Cited by 64
Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats
Jiménez‐Aranda, A., Fernández‐Vázquez, G., A‐Serrano, M. M., Reiter, R. J., & Agil, A. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12147 · Cited by 64
Preventive obesity agent montmorillonite adsorbs dietary lipids and enhances lipid excretion from the digestive tract
Xu, P., Dai, S., Wang, J., Zhang, J., Liu, J., Wang, F., & Zhai, Y. (2016) · Scientific Reports · doi:10.1038/srep19659 · Cited by 39
Self-citation
Possible Involvement of the Inhibition of NF‐κB Factor in Anti‐Inflammatory Actions That Melatonin Exerts on Mast Cells
y Aibar, M. D. M., García‐Moreno, H., González-Yanes, C., & Calvo, J. R. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25491 · Cited by 36
Melatonin in the Biliary Tract and Liver: Health Implications
Reiter, R. J., Rosales‐Corral, S., Manchester, L. C., Liu, X., & Tan, D. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612819666131119105826 · Cited by 34
Effects of Short Photoperiod and Melatonin Treatment on Thermogenesis in the Syrian Hamster
Viswanathan, M. N., Hissa, R., & George, J. C. (1986) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1986.tb00754.x · Cited by 32
RORα inhibits adipocyte-conditioned medium-induced colorectal cancer cell proliferation and migration and chick embryo chorioallantoic membrane angiopoiesis
Xiao, L., Wang, J., Li, J., Chen, X., Xu, P., Sun, S., He, D., Cong, Y., & Zhai, Y. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00091.2014 · Cited by 30
Self-citation
Diurnal Changes in Sensitivity to Melatonin in Intact and Pinealectomized Djungarian Hamsters: Effects on Thermogenesis, Cold Tolerance, and Gonads
Holtorf, A., Heldmaier, G., Thiele, G., & Steinlechner, S. (1985) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1985.tb00719.x · Cited by 30
Prevalence and trends in overweight and obesity among Chinese adults in 2004–10: data from three nationwide surveys in China
Jiang, Y., Xu, Y., Bi, Y., Wang, L., Zhang, M., Zhou, M., Yichong, L., Xu, M., Lu, J., Wang, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00658-3 · Cited by 26
Editorial (Thematic Issues: Basic and Clinical Aspects of Melatonin in the Gastrointestinal Tract. New Advancements and Future Perspectives)
Brzozowski, T., & Jaworek, J. M. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612819666131119111201 · Cited by 15
Experimental Helicobacter marmotae infection in A/J mice causes enterohepatic disease
Patterson, M. M., Rogers, A. B., & Fox, J. G. (2010) · Journal of Medical Microbiology · doi:10.1099/jmm.0.020479-0 · Cited by 12

Research works printed but not linked: 1

Sajan MP, 2008, Activation of sterol receptor element binding protein‐1c and nfkb by atypical protein kinase c in liver mediates lipid abnormalities and insulin resistance in murine obesity models, Diabetes, 57, A376

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Authors: Xu, P., Wang, J., Hong, F., Wang, S., Jin, X., Xue, T., Jia, L., & Zhai, Y.
Affiliations: Beijing Normal University (CN)
Beijing Key Laboratory of Gene Resource and Molecular Development College of Life Sciences Beijing Normal University Beijing China
Corresponding author: Zhai, Yonggong
ORCID: Xu, Pengfei
Wang, Jialin
Jin, Xi
Zhai, Yonggong
Venue: Journal of Pineal Research
Publisher: Wiley
Published: 2017-03-10
Volume: 62
Issue: 4
ISSN: 0742-3098 (ISSN-L)
1600-079X
DOI: 10.1111/jpi.12399
OpenAlex: W2587996254
Cited by: 281
References: 65
Citations by year: 2026: 9 · 2025: 17 · 2024: 28 · 2023: 36 · 2022: 48 · 2021: 51 · 2020: 36 · 2019: 27 · 2018: 21 · 2017: 8
FWCI: 10.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Pineal Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31571164, 31271207)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: melatonin, obesity, gut microbiota, dysbiosis, high-fat diet, body weight, hepatic steatosis, insulin resistance, low-grade inflammation, Akkermansia, Firmicutes/Bacteroidetes ratio, mucin-degrading bacteria, probiotics
MeSH terms: Firmicutes, Bacillota, Gastrointestinal Microbiome, Animals, Central Nervous System Depressants, Fatty Liver, Inflammation, Insulin Resistance, Male, Melatonin, Mice, Inbred C57BL, Obesity, Blotting, Western, Weight Gain, Glucose Intolerance, Probiotics, Bacteroidetes, Mice, Diet, High-Fat

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Melatonin prevents obesity through modulation of gut microbiota in mice

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