Cited by 282Gut microbiota and healthCircadian rhythm and melatoninRegulation of Appetite and Obesity

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Melatonin prevents obesity through modulation of gut microbiota in mice

Xu, Pengfei, Wang, Jialin, Hong, Fan, Wang, Sheng, Jin, Xi, Xue, Tingting, Jia, Li, Zhai, Yonggong·2017·Journal of Pineal Research

DOI 10.1111/jpi.12399

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Abstract

Excess weight and obesity are severe public health threats worldwide. Recent evidence demonstrates that gut microbiota dysbiosis contributes to obesity and its comorbidities. The body weight‐reducing and energy balancing effects of melatonin have been reported in several studies, but to date, no investigations toward examining whether the beneficial effects of melatonin are associated with gut microbiota have been carried out. In this study, we show that melatonin reduces body weight, liver steatosis, and low‐grade inflammation as well as improving insulin resistance in high fat diet (HFD)‐fed mice. High‐throughput pyrosequencing of the 16S rRNA demonstrated that melatonin treatment significantly changed the composition of the gut microbiota in mice fed an HFD. The richness and diversity of gut microbiota were notably decreased by melatonin. HFD feeding altered 69 operational taxonomic units (OTU s) compare with a normal chow diet (NCD) group, and melatonin supplementation reversed 14 OTU s to the same configuration than those present in the NCD group, thereby impacting various functions, in particular through its ability to decrease the Firmicutes‐to‐Bacteroidetes ratio and increase the abundance of mucin‐degrading bacteria Akkermansia, which is associated with healthy mucosa. Taken together, our results suggest that melatonin may be used as a probiotic agent to reverse HFD‐induced gut microbiota dysbiosis and help us to gain a better understanding of the mechanisms governing the various melatonin beneficial effects.

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Authors: Xu, P., Wang, J., Hong, F., Wang, S., Jin, X., Xue, T., Jia, L., & Zhai, Y.
Affiliations: Beijing Normal University (CN)
Beijing Key Laboratory of Gene Resource and Molecular Development College of Life Sciences Beijing Normal University Beijing China
Corresponding author: Zhai, Yonggong
ORCID: Xu, Pengfei
Wang, Jialin
Jin, Xi
Zhai, Yonggong
Venue: Journal of Pineal Research
Publisher: Wiley
Published: 2017-03-10
Volume: 62
Issue: 4
ISSN: 0742-3098 (ISSN-L)
1600-079X
DOI: 10.1111/jpi.12399
OpenAlex: W2587996254
Cited by: 281
References: 65
Citations by year: 2026: 9 · 2025: 17 · 2024: 28 · 2023: 36 · 2022: 48 · 2021: 51 · 2020: 36 · 2019: 27 · 2018: 21 · 2017: 8
FWCI: 10.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Pineal Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31571164, 31271207)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: melatonin, obesity, gut microbiota, dysbiosis, high-fat diet, body weight, hepatic steatosis, insulin resistance, low-grade inflammation, Akkermansia, Firmicutes/Bacteroidetes ratio, mucin-degrading bacteria, probiotics
MeSH terms: Firmicutes, Bacillota, Gastrointestinal Microbiome, Animals, Central Nervous System Depressants, Fatty Liver, Inflammation, Insulin Resistance, Male, Melatonin, Mice, Inbred C57BL, Obesity, Blotting, Western, Weight Gain, Glucose Intolerance, Probiotics, Bacteroidetes, Mice, Diet, High-Fat

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Melatonin prevents obesity through modulation of gut microbiota in mice

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