The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Coagulopathy in COVID‐19
Open accessAbstract
The COVID‐19 pandemic has become an urgent issue in every country. Based on recent reports, the most severely ill patients present with coagulopathy, and disseminated intravascular coagulation (DIC)‐like massive intravascular clot formation is frequently seen in this cohort. Therefore, coagulation tests may be considered useful to discriminate severe cases of COVID‐19. The clinical presentation of COVID‐19‐associated coagulopathy is organ dysfunction primarily, whereas hemorrhagic events are less frequent. Changes in hemostatic biomarkers represented by increase in D‐dimer and fibrin/fibrinogen degradation products indicate the essence of coagulopathy is massive fibrin formation. In comparison with bacterial‐sepsis‐associated coagulopathy/DIC, prolongation of prothrombin time, and activated partial thromboplastin time, and decrease in antithrombin activity is less frequent and thrombocytopenia is relatively uncommon in COVID‐19. The mechanisms of the coagulopathy are not fully elucidated, however. It is speculated that the dysregulated immune responses orchestrated by inflammatory cytokines, lymphocyte cell death, hypoxia, and endothelial damage are involved. Bleeding tendency is uncommon, but the incidence of thrombosis in COVID‐19 and the adequacy of current recommendations regarding standard venous thromboembolic dosing are uncertain.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
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Cited by
Lamers, M. M., & Haagmans, B. L. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00713-0 · Cited by 983
Mandal, S., Barnett, J., Brill, S. E., Brown, J. S., Denneny, E. K., Hare, S. S., Heightman, M., Hillman, T. E., Jacob, J., Jarvis, H. C., et al. (2021) · Thorax · doi:10.1136/thoraxjnl-2020-215818 · Cited by 864
The unique characteristics of COVID-19 coagulopathy
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Metadata
- Authors
- Iba, T., Levy, J. H., Levi, M., & Thachil, J.
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 18
- Issue
- 9
- Pages
- 2103-2109
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W3036512428
- Cited by
- 585
- References
- 52
- FWCI
- 14.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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