The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
On the accumulation of deleterious mutations during range expansions
Abstract
We investigate the effect of spatial range expansions on the evolution of fitness when beneficial and deleterious mutations cosegregate. We perform individual‐based simulations of 1 D and 2 D range expansions and complement them with analytical approximations for the evolution of mean fitness at the edge of the expansion. We find that deleterious mutations accumulate steadily on the wave front during range expansions, thus creating an expansion load. Reduced fitness due to the expansion load is not restricted to the wave front, but occurs over a large proportion of newly colonized habitats. The expansion load can persist and represent a major fraction of the total mutation load for thousands of generations after the expansion. The phenomenon of expansion load may explain growing evidence that populations that have recently expanded, including humans, show an excess of deleterious mutations. To test the predictions of our model, we analyse functional genetic diversity in humans and find patterns that are consistent with our model.
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Assessing the evolutionary impact of amino acid mutations in the human genome.
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Understanding Inbreeding Depression, Purging, and Genetic Rescue
Hedrick, P. W., & Garcia-Dorado, A. (2016) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2016.09.005 · Cited by 668
Marsden, C. D., Ortega-Del Vecchyo, D., O’Brien, D. P., Taylor, J. F., Ramirez, O., Vilà, C., Marques-Bonet, T., Schnabel, R. D., Wayne, R. K., & Lohmueller, K. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512501113 · Cited by 333
Estimating the mutation load in human genomes
Henn, B. M., Botigué, L. R., Bustamante, C. D., Clark, A. G., & Gravel, S. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3931 · Cited by 281
Genetic Costs of Domestication and Improvement
Moyers, B. T., Morrell, P. L., & McKay, J. K. (2018) · Journal of Heredity · doi:10.1093/jhered/esx069 · Cited by 216
The distribution of deleterious genetic variation in human populations
Lohmueller, K. E. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.005 · Cited by 131
Metadata
- Authors
- Peischl, S., Dupanloup, I., Kirkpatrick, M., & Excoffier, L.
- Venue
- Molecular Ecology
- Publisher
- Wiley
- Published
- 2013-11-04
- Volume
- 22
- Issue
- 24
- Pages
- 5972-5982
- ISSN
- 0962-1083 (ISSN-L)
- 1365-294X
- OpenAlex
- W2012294035
- Cited by
- 318
- References
- 13
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- closed
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