Genetic Costs of Domestication and Improvement
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Abstract
The "cost of domestication" hypothesis posits that the process of domesticating wild species can result in an increase in the number, frequency, and/or proportion of deleterious genetic variants that are fixed or segregating in the genomes of domesticated species. This cost may limit the efficacy of selection and thus reduce genetic gains in breeding programs for these species. Understanding when and how deleterious mutations accumulate can also provide insight into fundamental questions about the interplay of demography and selection. Here we describe the evolutionary processes that may contribute to deleterious variation accrued during domestication and improvement, and review the available evidence for "the cost of domestication" in animal and plant genomes. We identify gaps and explore opportunities in this emerging field, and finally offer suggestions for researchers and breeders interested in understanding or avoiding the consequences of an increased number or frequency of deleterious variants in domesticated species.
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The role of domestication as a driver for conservation and management of endangered species is controversial.
“While the role of domestication as a driver for conservation and management of endangered species is controversial140–142, it could be one facet of an integrated adaptive solution that is locally implemented.”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [142]
The Conclusions (page unavailable) discuss genetic costs in domesticated species, and Predictive Algorithms (page unavailable) discusses phylogenetic conservation as a way to assess genetic variants. Neither addresses whether using domestication to conserve or manage endangered species is controversial. Searches for endangered-species conservation, management, and captive breeding found no passage on that point. (LLM, conf=0.76)
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Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Paton, T., Wintle, R. F., Engstrom, M. D., Gunn, A., & Scherer, S. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-67270-9 · Cited by 4 · see citing works
“While the role of domestication as a driver for conservation and management of endangered species is controversial 140–142 , it could be one facet of an integrated adaptive solution that is locally implemented.”
Background
- Authors
- Moyers, B. T., Morrell, P. L., & McKay, J. K.
- Affiliations
- Colorado State University (US)
- University of Minnesota (US)
- Corresponding author
- Moyers, Brook T
- Venue
- Journal of Heredity
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-08-04
- Volume
- 109
- Issue
- 2
- Pages
- 103-116
- ISSN
- 0022-1503 (ISSN-L)
- 1465-7333
- OpenAlex
- W2952255385
- Cited by
- 216
- References
- 171
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 24 · 2023: 27 · 2022: 37 · 2021: 26 · 2020: 27 · 2019: 15 · 2018: 10 · 2017: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Heredity (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1523752, DBI 1339393)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- deleterious mutations, domestication, plant breeding, animal breeding, genetic gain, selection efficacy
- MeSH terms
- Mutation Accumulation, Domestication, Animals, Breeding, Biological Evolution, Humans, Hybrid Vigor, Inbreeding, Plants, Genetic Variation, Genome, Genome, Plant
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