Fecal Microbiota Transplantation: Indications, Methods, Evidence, and Future Directions

Borody, Thomas J.; Paramsothy, Sudarshan; Agrawal, Gaurav

doi:10.1007/s11894-013-0337-1

Cited by 275Clostridium difficile and Clostridium perfringens researchGut microbiota and healthGastrointestinal motility and disorders

Fecal Microbiota Transplantation: Indications, Methods, Evidence, and Future Directions

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Borody, Thomas J., Paramsothy, Sudarshan, Agrawal, Gaurav·2013·Current Gastroenterology Reports

DOI 10.1007/s11894-013-0337-1PMC PMC3742951

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Abstract

Fecal microbiota transplantation (FMT) has attracted great interest in recent years, largely due to the global Clostridium difficile infection (CDI) epidemic and major advances in metagenomic sequencing of the gastrointestinal (GI) microbiota, with growing understanding of its structure and function. FMT is now recommended as the most effective therapy for relapsing CDI and, with further refinement, may even be used in "first-time" CDI. There is interest also in other conditions related to GI dysbiosis--for example, inflammatory bowel disease, irritable bowel syndrome, obesity, and diabetes mellitus--although quality evidence is at present lacking. A few trials are now underway in FMT for ulcerative colitis. Many unanswered questions remain, including FMT methodology--for example, optimal route of administration, what makes a "good donor," safety issues, and long-term effects of FMT.

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Since that publication, the lead Author has treated with FMT more than 300 D-IBS patients whose symptoms had failed to respond to conventional therapies.
“Since that publication, the lead Author has treated with FMT more than 300 DIBS patients whose symptoms had failed to respond to conventional therapies [306]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [306]

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A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works
Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
Cohen, S. H., Gerding, D. N., Johnson, S., Kelly, C. P., Loo, V. G., McDonald, L. C., Pépin, J., & Wilcox, M. H. (2010) · Infection Control and Hospital Epidemiology · doi:10.1086/651706 · Cited by 2,931 · see citing works
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436 · see citing works
Inducible Foxp3 + regulatory T-cell development by a commensal bacterium of the intestinal microbiota
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works
Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections
Surawicz, C. M., Brandt, L. J., Binion, D. G., Ananthakrishnan, A. N., Curry, S. R., Gilligan, P. H., McFarland, L. V., Mellow, M., & Zuckerbraun, B. S. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.4 · Cited by 1,645 · see citing works
H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE
Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623 · see citing works
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604 · see citing works
Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076 · see citing works
Treating Clostridium difficile infection with fecal microbiota transplantation
Bakken, J. S., Borody, T., Brandt, L. J., Brill, J. V., Demarco, D. C., Franzos, M. A., Kelly, C., Khoruts, A., Louie, T., Martinelli, L. P., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.08.014 · Cited by 1,003 · see citing works
Self-citation
Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection
Gough, E., Shaikh, H., & Manges, A. R. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir632 · Cited by 1,003 · see citing works
Untitled work
(1958) · PubMed · Cited by 978 · see citing works
Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis
Kassam, Z., Lee, C. H., Yuan, Y., & Hunt, R. H. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.59 · Cited by 904 · see citing works
Homeostasis and Inflammation in the Intestine
Garrett, W. S., Gordon, J. I., & Glimcher, L. H. (2010) · Cell · doi:10.1016/j.cell.2010.01.023 · Cited by 784 · see citing works
Obesity and the human microbiome
Ley, R. E. (2009) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328333d751 · Cited by 760 · see citing works
Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection
Hamilton, M. J., Weingarden, A. R., Sadowsky, M. J., & Khoruts, A. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.482 · Cited by 738 · see citing works
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut
Petrof, E. O., Gloor, G. B., Vanner, S. J., Weese, S. J., Carter, D., Daigneault, M. C., Brown, E. M., Schroeter, K., & Allen-Vercoe, E. (2013) · Microbiome · doi:10.1186/2049-2618-1-3 · Cited by 731 · see citing works
Fecal microbiota transplantation and emerging applications
Borody, T. J., & Khoruts, A. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.244 · Cited by 677 · see citing works
Self-citation
Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection
Brandt, L. J., Aroniadis, O. C., Mellow, M., Kanatzar, A., Kelly, C., Park, T., Stollman, N., Rohlke, F., & Surawicz, C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.60 · Cited by 672 · see citing works
Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea
Khoruts, A., Dicksved, J., Jansson, J. K., & Sadowsky, M. J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181c87e02 · Cited by 649 · see citing works
Should we standardize the 1,700-year-old fecal microbiota transplantation?
Zhang, F., Luo, W., Shi, Y., Fan, Z., & Ji, G. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.251 · Cited by 619 · see citing works
BACTERIOTHERAPY FOR CHRONIC RELAPSING CLOSTRIDIUM DIFFICILE DIARRHOEA IN SIX PATIENTS
Tvede, M., & Rask-Madsen, J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92749-9 · Cited by 595 · see citing works
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice
Lawley, T. D., Clare, S., Walker, A. W., Stares, M. D., Connor, T. R., Raisen, C., Goulding, D., Rad, R., Schreiber, F., Brandt, C., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002995 · Cited by 540 · see citing works
Gastrointestinal microbiology enters the metagenomics era
Frank, D. N., & Pace, N. R. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f2b0e8 · Cited by 405 · see citing works
Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy
Borody, T. J., Warren, E. F., Leis, S., Surace, R., & Ashman, O. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200307000-00012 · Cited by 388 · see citing works
Self-citation
Techniques used to characterize the gut microbiota: a guide for the clinician
Fraher, M. H., O'Toole, P. W., & Quigley, E. M. M. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.44 · Cited by 385 · see citing works
Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection
Mattila, E., Uusitalo–Seppälä, R., Wuorela, M., Lehtola, L., Nurmi, H., Ristikankare, M., Moilanen, V., Salminen, K., Seppälä, M., Mattila, P. S., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.11.037 · Cited by 371 · see citing works
PROSPECTIVE DIAGNOSIS OF SPINA BIFIDA
Brock, D. J. H., Scrimgeour, J. B., Chard, T., Leek, A. E., KITAU, M. J., & Leighton, P. C. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91459-2 · Cited by 361 · see citing works
The Relationship Between Gut Microbiota and Weight Gain in Humans
Angelakis, E., Armougom, F., Million, M., & Raoult, D. (2011) · Future Microbiology · doi:10.2217/fmb.11.142 · Cited by 357 · see citing works
Role of the microbiota in inflammatory bowel diseases
Nagalingam, N. A., & Lynch, S. V. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21866 · Cited by 315 · see citing works
High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria
Hamilton, M. J., Weingarden, A. R., Unno, T., Khoruts, A., & Sadowsky, M. J. (2013) · Gut Microbes · doi:10.4161/gmic.23571 · Cited by 315 · see citing works
Safety, tolerability, and clinical response after fecal transplantation in children and young adults with ulcerative colitis
Kunde, S., Pham, A., Bonczyk, S., Crumb, T., Duba, M., Conrad, H., Cloney, D., & Kugathasan, S. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318292fa0d · Cited by 314 · see citing works
Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
Anderson, J. E., Edney, R. J., & Whelan, K. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05220.x · Cited by 313 · see citing works
Treatment of ulcerative colitis by implantation of normal colonic flora
Bennet, J., & Brinkman, M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91183-5 · Cited by 304 · see citing works
Bacteriotherapy for chronic relapsing Clostridium difficile in six patients
Tvede, M. (1989) · The Lancet · Cited by 290 · see citing works
Bacteriotherapy Using Fecal Flora: Toying With Human Motions
Borody, T. J., Warren, E. F., Leis, S. M., Surace, R., Ashman, O., & Siarakas, S. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128988.13808.dc · Cited by 283 · see citing works
Self-citation
Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome?
Borody, T. J., George, L., Andrews, P., Brandl, S., Noonan, S., Cole, P., Hyland, L., Morgan, A., Maysey, J., & Moore‐Jones, D. (1989) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1989.tb136704.x · Cited by 221 · see citing works
Self-citation
Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome
Zupancic, M. L., Cantarel, B. L., Liu, Z., Drábek, E. F., Ryan, K. A., Cirimotich, S., Jones, C. E., Knight, R. D., Walters, W. A., Knights, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043052 · Cited by 213 · see citing works
Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection in 26 Patients
Kelly, C. R., de Leon, L., & Jasutkar, N. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318234570b · Cited by 189 · see citing works
Alternative treatments for Clostridium difficile disease: what really works?
McFarland, L. V. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45753-0 · Cited by 178 · see citing works
American Journal of Gastroenterology Lecture: Intestinal Microbiota and the Role of Fecal Microbiota Transplant (FMT) in Treatment of C. difficile Infection
Brandt, L. J. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.450 · Cited by 171 · see citing works
Fecal Transplant via Retention Enema for Refractory or Recurrent Clostridium difficile Infection
Kassam, Z. (2012) · Archives of Internal Medicine · doi:10.1001/archinte.172.2.191 · Cited by 128 · see citing works
Fecal transplant against relapsingClostridium difficile-associated diarrhea in 32 patients
Jorup-Rönström, C., Håkanson, A., Sandell, S., Edvinsson, O., Midtvedt, T., Persson, A., & Norin, E. L. (2012) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2012.672587 · Cited by 82 · see citing works
Reversal of Idiopathic Thrombocytopenic Purpura [ITP] with Fecal Microbiota Transplantation [FMT]
Borody, T. J., Campbell, J., Torres, M., Nowak, A. K., & Leis, S. (2011) · The American Journal of Gastroenterology · doi:10.14309/00000434-201110002-00941 · Cited by 74 · see citing works
Self-citation
Sa1922 Pilot Study on the Safety and Efficacy of Faecal Microbiota Transplantation in Refractory Crohn's Disease
Vermeire, S., Joossens, M., Verbeke, K., Hildebrand, F., Machiels, K., Van den Broeck, K., Van Assche, G., Rutgeerts, P. J., & Raes, J. (2012) · Gastroenterology · doi:10.1016/s0016-5085(12)61356-0 · Cited by 63 · see citing works
13. Bakken JS, Borody T, Brandt LJ, et al.; Fecal Microbiota Transplantation Workgroup. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol. 2011;9:1044-1049. 14. Brandt LJ, Reddy SS. Fecal microbiota transplantation for recurrent
LaCourse, S. M., Chester, F. M., Preidis, G. A., McCrary, L. M., Arscott‐Mills, T., James, G., McCollum, E. D., & Hosseinipour, M. C. (2014) · Cited by 57 · see citing works
Clostridium difficile Infection and Inflammatory Bowel Disease
Reddy, S. S., & Brandt, L. J. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31828b288a · Cited by 52 · see citing works
The Bowel Microbiota and Inflammatory Bowel Diseases
Tannock, G. W. (2010) · International Journal of Inflammation · doi:10.4061/2010/954051 · Cited by 49 · see citing works
Fecal Microbiota Transplantation in Ulcerative Colitis: Review of 24 Years Experience
Borody, T. J., Wettstein, A. R., Campbell, J., Leis, S., Torres, M., Finlayson, S., & Nowak, A. K. (2012) · The American Journal of Gastroenterology · doi:10.14309/00000434-201210001-01644 · Cited by 32 · see citing works
Self-citation
Treatment of Recurrent Clostridium difficile Diarrhea.
Huebner, E. S., & Surawicz, C. M. (2006) · PubMed · Cited by 29 · see citing works
Bacteriotherapy in Chronic Fatigue Syndrome (CFS): A Retrospective Review
Borody, T. J., Nowak, A., Torres, M., Campbell, J., Finlayson, S., & Leis, S. (2012) · The American Journal of Gastroenterology · doi:10.14309/00000434-201210001-01481 · Cited by 26 · see citing works
Self-citation
M1209 Clostridium difficile Complicating Inflammatory Bowel Disease: Pre- and Post-Treatment Findings
Borody, T. J., Wettstein, A. R., Leis, S., Hills, L. A., Campbell, J., & Torres, M. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)61684-4 · Cited by 19 · see citing works
Self-citation
Long-Term Follow-Up Study of Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis (UC)
Brandt, L. J., & Aroniadis, O. C. (2012) · The American Journal of Gastroenterology · doi:10.14309/00000434-201210001-01626 · Cited by 7 · see citing works
Print and Media Review
Fisher, R. C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.028 · Cited by 6 · see citing works

Flagged first, then by citations

1 of the 62 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

[44]Borody T, Leis S, McGrath K et al. Treatment of Chronic Constipation and Colitis using human probiotic infusions. Probiotics, Prebiotics and New Foods Conference, Universita Urbaniana, Rome, Sept 2–4 2001
[58]58: Kahn SA, Goeppinger SR, Rubin DT. Fecal Transplantation: a new therapy for IBD? Proceeding with Caution. Inflamm Bowel Dis Monit 2013; accepted manuscript [in press]

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Ayukekbong, J. A., Ntemgwa, M., & Atabe, A. N. (2017) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-017-0208-x · Cited by 1,315 · see citing works
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Chang, C., Lin, C.-S., Lu, C., Martel, J., Ko, Y., Ojcius, D. M., Tseng, S., Wu, T.-R., Chen, Y. M., Young, J. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms8489 · Cited by 1,251 · see citing works
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Cammarota, G., Ianiro, G., & Gasbarrini, A. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000046 · Cited by 428 · see citing works
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Parekh, P. J., Balart, L. A., & Johnson, D. A. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.16 · Cited by 219 · see citing works
Altered Duodenal Microbiota Composition in Celiac Disease Patients Suffering From Persistent Symptoms on a Long-Term Gluten-Free Diet
Wacklin, P., Laurikka, P., Lindfors, K., Collin, P., Salmi, T. T., Lähdeaho, M., Saavalainen, P., Mäki, M., Mättö, J., Kurppa, K., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.355 · Cited by 202 · see citing works
Radiotherapy and the gut microbiome: facts and fiction
Liu, J., Liu, C., & Yue, J. (2021) · Radiation Oncology · doi:10.1186/s13014-020-01735-9 · Cited by 183 · see citing works
Microbiota Dynamics in Patients Treated with Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection
Song, Y., Garg, S., Girotra, M., Maddox, C., von Rosenvinge, E. C., Dutta, A., Dutta, S., & Fricke, W. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081330 · Cited by 169 · see citing works
Gut Microbiota Dysbiosis as Risk and Premorbid Factors of IBD and IBS Along the Childhood–Adulthood Transition
Putignani, L., CHIERICO, F. D., Vernocchi, P., Cicala, M., Cucchiara, S., & Dallapiccola, B. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000602 · Cited by 150 · see citing works
Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders
Evrensel, A., & Ceylan, M. E. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.3.231 · Cited by 150 · see citing works
Fecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes?
Aron‐Wisnewsky, J., Clément, K., & Nieuwdorp, M. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1180-z · Cited by 144 · see citing works
The Microbiota-Inflammasome Hypothesis of Major Depression
Inserra, A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · BioEssays · doi:10.1002/bies.201800027 · Cited by 134 · see citing works
Captivity and Animal Microbiomes: Potential Roles of Microbiota for Influencing Animal Conservation
Dallas, J. W., & Warne, R. W. (2022) · Microbial Ecology · doi:10.1007/s00248-022-01991-0 · Cited by 134 · see citing works
Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease
Wang, Z.-K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14805 · Cited by 132 · see citing works
Fatal Aspiration Pneumonia as a Complication of Fecal Microbiota Transplant
Baxter, M., Ahmad, T., Colville, A., & Sheridan, R. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ247 · Cited by 126 · see citing works
Treating Obesity and Metabolic Syndrome with Fecal Microbiota Transplantation.
Marotz, C. A., & Zarrinpar, A. (2016) · PubMed Central · Cited by 125 · see citing works
Predictors of Early Failure After Fecal Microbiota Transplantation for the Therapy of Clostridium Difficile Infection: A Multicenter Study
Fischer, M., Kao, D. H., Mehta, S. R., Martin, T., Dimitry, J., Keshteli, A. H., Cook, G. K., Phelps, E. L., Sipe, B. W., Xu, H., et al. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.180 · Cited by 124 · see citing works
Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response
Elhag, D. A., Kumar, M., Saadaoui, M., Akobeng, A. K., Al-Mudahka, F., Elawad, M., & Khodor, S. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136966 · Cited by 124 · see citing works
Therapeutic faecal microbiota transplantation: current status and future developments
Borody, T. J., Brandt, L. J., & Paramsothy, S. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000027 · Cited by 114 · see citing works
Self-citation
Combinatorial Effects of Diet and Genetics on Inflammatory Bowel Disease Pathogenesis
Dixon, L. J., Kabi, A., Nickerson, K. P., & McDonald, C. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000289 · Cited by 113 · see citing works
Hair Growth in Two Alopecia Patients after Fecal Microbiota Transplant
Rebello, D., Wang, E. J., Yen, E. F., Lio, P., & Kelly, C. R. (2017) · ACG Case Reports Journal · doi:10.14309/crj.2017.107 · Cited by 113 · see citing works
The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future
Andermann, T. M., Peled, J. U., Ho, C. M., Reddy, P. R., Riches, M., Storb, R. F., Teshima, T., van den Brink, M. R. M., Alousi, A. M., Balderman, S., et al. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.02.009 · Cited by 112 · see citing works
Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences
Salem, F., Kindt, N., Marchesi, J. R., Netter, P., Lopez, A., Kökten, T., Danese, S., Jouzeau, J., Peyrin‐Biroulet, L., & Moulin, D. (2019) · United European Gastroenterology Journal · doi:10.1177/2050640619867555 · Cited by 106 · see citing works
Ripened Pu-erh Tea Extract Protects Mice from Obesity by Modulating Gut Microbiota Composition
Lu, X., Liu, J., Zhang, N., Fu, Y., Zhang, Z., Li, Y., Wang, W., Li, Y., Shen, P. F., & Cao, Y. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b04909 · Cited by 105 · see citing works
Disturbed microbial ecology in Alzheimer’s disease: evidence from the gut microbiota and fecal metabolome
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02286-z · Cited by 103 · see citing works
Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis
Tang, B., Zhu, J., Fang, S., Wang, Y., Rajamanickam, V., Li, M., Weng, Q., Zheng, L., Yang, Y., Qiu, R., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.012 · Cited by 100 · see citing works
Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy
Luo, L., Luo, J., Cai, Y., Fu, M., Li, W., Shi, L., Liu, J., Dong, R., Xu, X., Tu, L., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106367 · Cited by 99 · see citing works
Gut microbiota differs between children with Inflammatory Bowel Disease and healthy siblings in taxonomic and functional composition: a metagenomic analysis
Knoll, R. L., Forslund, S. K., Kultima, J. R., Meyer, C. U., Kullmer, U., Sunagawa, S., Bork, P., & Gehring, S. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00293.2016 · Cited by 94 · see citing works
The human microbiome in hematopoiesis and hematologic disorders
Manzo, V. E., & Bhatt, A. S. (2015) · Blood · doi:10.1182/blood-2015-04-574392 · Cited by 93 · see citing works
Role of the gastrointestinal microbiota in small animal health and disease
Redfern, A., Suchodolski, J. S., & Jergens, A. E. (2017) · Veterinary Record · doi:10.1136/vr.103826 · Cited by 90 · see citing works
An ecological framework to understand the efficacy of fecal microbiota transplantation
Xiao, Y., Angulo, M. T., Lao, S., Weiss, S. T., & Liu, Y.-Y. (2020) · Nature Communications · doi:10.1038/s41467-020-17180-x · Cited by 89 · see citing works
Atorvastatin alleviates microglia-mediated neuroinflammation via modulating the microbial composition and the intestinal barrier function in ischemic stroke mice
Zhang, P., Zhang, X., Huang, Y., Chen, J., Shang, W., Shi, G., Zhang, L., Zhang, C., & Chen, R. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.032 · Cited by 87 · see citing works
Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases
Hou, S., Yu, J., Li, Y., Zhao, D., & Zhang, Z. (2025) · Advanced Science · doi:10.1002/advs.202413197 · Cited by 93 · see citing works
Cross-fostering immediately after birth induces a permanent microbiota shift that is shaped by the nursing mother
Daft, J. G., Ptacek, T., Kumar, R., Morrow, C. D., & Lorenz, R. G. (2015) · Microbiome · doi:10.1186/s40168-015-0080-y · Cited by 84 · see citing works
The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline
Shah, Z., & Alsegiani, A. S. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335837 · Cited by 83 · see citing works
Gut microbiota in pathophysiology, diagnosis, and therapeutics of inflammatory bowel disease
Pandey, H., Jain, D., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Intestinal Research · doi:10.5217/ir.2023.00080 · Cited by 88 · see citing works
MVP: a microbe–phage interaction database
Gao, N., Zhang, C., Zhang, Z., Hu, S., Lercher, M. J., Zhao, X., Peer Bork, B., Liu, Z., & Chen, W.-H. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1124 · Cited by 79 · see citing works
Gut microbiota-derived short chain fatty acids act as mediators of the gut–brain axis targeting age-related neurodegenerative disorders: a narrative review
Guo, B., Zhang, J., Zhang, W., Chen, F., & Liu, B. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2272769 · Cited by 84 · see citing works
Fecal Microbiota Transplantation in Inflammatory Bowel Disease
Boicean, A., Bîrluțiu, V., Ichim, C., Anderco, P., & Bîrsan, S. (2023) · Biomedicines · doi:10.3390/biomedicines11041016 · Cited by 83 · see citing works
Fecal microbiota transplantation for managing irritable bowel syndrome
El‐Salhy, M., & Mazzawi, T. R. E. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1447380 · Cited by 79 · see citing works
Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis
Park, D. H., Kim, J. W., Park, H., & Hahm, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084228 · Cited by 76 · see citing works
Inferring human microbial dynamics from temporal metagenomics data: Pitfalls and lessons
Cao, H., Gibson, T. E., Bashan, A., & Liu, Y. (2016) · BioEssays · doi:10.1002/bies.201600188 · Cited by 73 · see citing works
Ophiopogonin D alleviates high‐fat diet‐induced metabolic syndrome and changes the structure of gut microbiota in mice
Chen, S., Li, X., Liu, L., Liu, C., & Han, X. (2017) · The FASEB Journal · doi:10.1096/fj.201700741rr · Cited by 74 · see citing works
Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency
Liu, L., Fu, Q., Li, T., Shao, K., Zhu, X., Cong, Y., & Zhao, X. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262855 · Cited by 73 · see citing works
Clinical translation of microbe‐based therapies: Current clinical landscape and preclinical outlook
Vargason, A. M., & Anselmo, A. C. (2018) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10093 · Cited by 71 · see citing works
Xanthoceraside Could Ameliorate Alzheimer’s Disease Symptoms of Rats by Affecting the Gut Microbiota Composition and Modulating the Endogenous Metabolite Levels
Zhou, H., Tai, J., Xu, H., Lu, X., & Meng, D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01035 · Cited by 72 · see citing works
Step-up fecal microbiota transplantation (FMT) strategy
Cui, B., Li, P., Xu, L., Peng, Z., Xiang, J., He, Z., Zhang, T., Ji, G., Nie, Y., Wu, K., et al. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1151608 · Cited by 72 · see citing works
Childhood Obesity: Immune Response and Nutritional Approaches
Magrone, T., & Jirillo, E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00076 · Cited by 67 · see citing works
“Just recently, fecal microbiota transplantation has been applied to patients with inflammatory bowel disease and obese patients (142).”
Background
Allicin‐induced host‐gut microbe interactions improves energy homeostasis
Zhang, C., He, X., Sheng, Y., Cui, Y., Xu, J., Zheng, S., Liu, J., Xu, W., Luo, Y., & Huang, K. (2020) · The FASEB Journal · doi:10.1096/fj.202001007r · Cited by 69 · see citing works
Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms
Ahmed, S., Ahmed, M. Z., Rafique, S., Almasoudi, S. E., Shah, M., Jalil, N. A. C., & Ojha, S. C. (2023) · BioMed Research International · doi:10.1155/2023/5250040 · Cited by 75 · see citing works
Intestinal microbiota: a novel perspective in colorectal cancer biotherapeutics
Ding, C., Tang, W., Fan, X., & Wu, G. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s170626 · Cited by 66 · see citing works
Humans as Superorganisms
Krämer, P., & Bressan, P. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615583131 · Cited by 66 · see citing works
Tong-Xie-Yao-Fang Regulates 5-HT Level in Diarrhea Predominant Irritable Bowel Syndrome Through Gut Microbiota Modulation
Li, J., Cui, H., Cai, Y., Lin, J., Song, X., Zhou, Z., Xiong, W.-T., Zhou, H., Bian, Y., & Wang, L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01110 · Cited by 64 · see citing works
Vulvovaginal candidosis: contemporary challenges and the future of prophylactic and therapeutic approaches
Chew, S. Y., & Than, L. T. L. (2016) · Mycoses · doi:10.1111/myc.12455 · Cited by 63 · see citing works
The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice
Zhu, H., He, Y., Ma, J., Zhou, J., Kong, M., Wu, C., Mao, Q., Lin, G., & Li, S.-L. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113271 · Cited by 63 · see citing works
Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet–Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis
Zhai, Z., Yang, Y., Chen, S., & Wu, Z. (2024) · Environmental Health Perspectives · doi:10.1289/ehp13913 · Cited by 68 · see citing works
Can fecal microbiota transplantation cure irritable bowel syndrome?
Halkjær, S. I., Boolsen, A. W., Günther, S., Christensen, A. H., & Petersen, A. M. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i22.4112 · Cited by 59 · see citing works
Conceptual Design of a Universal Donor Screening Approach for Vaginal Microbiota Transplant
DeLong, K., Bensouda, S., Zulfiqar, F., Zierden, H. C., Hoang, T., Abraham, A. G., Coleman, J. S., Cone, R. A., Gravitt, P. E., Hendrix, C. W., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00306 · Cited by 60 · see citing works
The Main Anthocyanin Monomer from Lycium ruthenicum Murray Fruit Mediates Obesity via Modulating the Gut Microbiota and Improving the Intestinal Barrier
Liu, P., Zhou, W., Xu, W., Peng, Y., Yan, Y., Lu, L., Mi, J., Zeng, X., & Cao, Y. (2021) · Foods · doi:10.3390/foods11010098 · Cited by 58 · see citing works
Gut microbiome as a biomarker of cardiometabolic disorders
Gózd-Barszczewska, A., Kozioł-Montewka, M., Barszczewski, P., Młodzińska, A., & Humińska‐Lisowska, K. (2017) · Annals of Agricultural and Environmental Medicine · doi:10.26444/aaem/75456 · Cited by 57 · see citing works
Eucommia bark/leaf extract improves HFD-induced lipid metabolism disorders via targeting gut microbiota to activate the Fiaf-LPL gut-liver axis and SCFAs-GPR43 gut-fat axis
Wang, Z., Sun, Y., Han, Y., Chen, X., Gong, P., Zhai, P., Yao, W., Ba, Q., & Wang, H. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154652 · Cited by 60 · see citing works
Anthropogenic interferences lead to gut microbiome dysbiosis in Asian elephants and may alter adaptation processes to surrounding environments
Moustafa, M. A. M., Chel, H. M., Thu, M. J., Bawm, S., Htun, L. L., Win, M. M., Oo, Z. M., Ohsawa, N., Lahdenperä, M., Mohamed, W. M. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80537-1 · Cited by 56 · see citing works
Microbes Central to Human Reproduction
Reid, G., Brigidi, P., Burton, J. P., Contractor, N., Duncan, S. H., Fargier, E., Hill, C., Lebeer, S., Martı́n, R., McBain, A. J., et al. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12319 · Cited by 53 · see citing works
Experimental design considerations in microbiota/inflammation studies
Moore, R. J., & Stanley, D. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.41 · Cited by 53 · see citing works
Role of Microbiota-Derived Hydrogen Sulfide (H2S) in Modulating the Gut–Brain Axis: Implications for Alzheimer’s and Parkinson’s Disease Pathogenesis
Munteanu, C., Onose, G., Rotariu, M., Poştaru, M., Turnea, M. A., & Galaction, A. (2024) · Biomedicines · doi:10.3390/biomedicines12122670 · Cited by 52 · see citing works
Fecal transplant policy and legislation
Vyas, D. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i1.6 · Cited by 51 · see citing works
Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice
Wu, H., Rao, Q., Ma, G., Yu, X., Zhang, C.-E., & Ma, Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01652 · Cited by 50 · see citing works
Predicting microbiome compositions from species assemblages through deep learning
Michel-Mata, S., Wang, X., Liu, Y., & Angulo, M. T. (2022) · iMeta · doi:10.1002/imt2.3 · Cited by 49 · see citing works
Laminaria japonica polysaccharide prevents high-fat-diet-induced insulin resistance in mice via regulating gut microbiota
Li, Q.-M., Zha, X., Zhang, W.-N., Liu, J., Pan, L., & Luo, J. (2021) · Food & Function · doi:10.1039/d0fo02100h · Cited by 47 · see citing works
The Role of the Human Microbiome in Chemical Toxicity
Koontz, J. M., Dancy, B. C. R., Horton, C. L., Stallings, J. D., DiVito, V. T., & Lewis, J. A. (2019) · International Journal of Toxicology · doi:10.1177/1091581819849833 · Cited by 48 · see citing works
Cost-Effectiveness Analysis of Five Competing Strategies for the Management of Multiple Recurrent Community-Onset Clostridium difficile Infection in France
Baro, E., Galperine, T. K., Deniès, F., Lannoy, D., Lenne, X., Odou, P., Guery, B. P., & Dervaux, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170258 · Cited by 46 · see citing works
Pilot study of cytokine changes evaluation after fecal microbiota transplantation in patients with ulcerative colitis
Wang, Y., Ren, R., Sun, G., Peng, L., Tian, Y., & Yang, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106661 · Cited by 46 · see citing works
Probiotic strains and mechanistic insights for the treatment of type 2 diabetes
Hampe, C. S., & Roth, C. L. (2017) · Endocrine · doi:10.1007/s12020-017-1433-z · Cited by 45 · see citing works
Fecal microbiota transplantation in gastrointestinal disease: 2015 update and the road ahead
Borody, T. J., Fischer, M., Mitchell, S., & Campbell, J. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1086267 · Cited by 44 · see citing works
Self-citation
Mining the fecal proteome: from biomarkers to personalised medicine
Jin, P., Wang, K., Huang, C., & Nice, E. C. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1314786 · Cited by 45 · see citing works
Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice
Shi, Y., Zou, Y., Xiong, Y., Zhang, S., Song, M., An, X., Liu, C., Zhang, W., & Chen, S. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1946369 · Cited by 44 · see citing works
Restoring the gut microbiome for the treatment of inflammatory bowel diseases
Allegretti, J. R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i13.3468 · Cited by 40 · see citing works
How Chinese clinicians face ethical and social challenges in fecal microbiota transplantation: a questionnaire study
Ma, Y., Yang, J., Cui, B., Xu, H., Xiao, C., & Zhang, F. (2017) · BMC Medical Ethics · doi:10.1186/s12910-017-0200-2 · Cited by 43 · see citing works
Disbiosis como factor determinante de enfermedad oral y sistémica: importancia del microbioma
Chimenos-Küstner, E., Giovannoni, M. L., & Schemel-Suárez, M. (2017) · Medicina clínica (Ed. impresa) · doi:10.1016/j.medcli.2017.05.036 · Cited by 13 · see citing works
Auricularia auricula-judae (Bull.) polysaccharides improve obesity in mice by regulating gut microbiota and TLR4/JNK signaling pathway
Zhou, Y., Jia, Y., Xu, N., Tang, L., & Chang, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126172 · Cited by 42 · see citing works
The effectiveness of multi-session FMT treatment in active ulcerative colitis patients: A pilot study
Mańkowska-Wierzbicka, D., Stelmach-Mardas, M., Gabryel, M., Tomczak, H., Skrzypczak-Zielińska, M., Zakerska-Banaszak, O., Sowińska, A., Mahadea, D., Baturo, A., Wolko, Ł., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8080268 · Cited by 39 · see citing works
Reshaping the Gut Microbiota at an Early Age: Functional Impact on Obesity Risk?
Luoto, R., Collado, M. C., Salminen, S., & Isolauri, E. (2013) · Annals of Nutrition and Metabolism · doi:10.1159/000354896 · Cited by 39 · see citing works
Technical Aspects of Fecal Microbial Transplantation (FMT)
Bhutiani, N., Schucht, J. E., Miller, K. R., & McClave, S. A. (2018) · Current Gastroenterology Reports · doi:10.1007/s11894-018-0636-7 · Cited by 39 · see citing works
Novel approaches to intervene gut microbiota in the treatment of chronic liver diseases
Liu, C., Wang, Y., Yang, Y., Zhang, N., Niu, C., Shen, X., & Wu, J. H. (2021) · The FASEB Journal · doi:10.1096/fj.202100939r · Cited by 37 · see citing works
Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
Rehman, A. U., Khan, A. I., Xin, Y., & Liang, W. (2022) · AMB Express · doi:10.1186/s13568-022-01451-5 · Cited by 37 · see citing works
The Role of Intestinal Microbiota in Acute Graft-versus-Host Disease
Chen, Y., Zhao, Y., Cheng, Q., Wu, D., & Liu, H. (2015) · Journal of Immunology Research · doi:10.1155/2015/145859 · Cited by 36 · see citing works

Authors: Borody, T. J., Paramsothy, S., & Agrawal, G.
Affiliations: Centre For Digestive Diseases (AU)
St Vincent's Hospital Sydney (AU)
Corresponding author: Borody, Thomas J.
ORCID: Borody, Thomas J.
Paramsothy, Sudarshan
Agrawal, Gaurav
Venue: Current Gastroenterology Reports
Publisher: Springer Science and Business Media LLC
Published: 2013-07-14
Volume: 15
Issue: 8
Pages: 337-337
ISSN: 1522-8037 (ISSN-L)
1534-312X
DOI: 10.1007/s11894-013-0337-1
PMC: PMC3742951
OpenAlex: W2112681005
Cited by: 275
References: 62
Citations by year: 2026: 7 · 2025: 11 · 2024: 23 · 2023: 25 · 2022: 15 · 2021: 41 · 2020: 21 · 2019: 20 · 2018: 22 · 2017: 23 · 2016: 20 · 2015: 19 · 2014: 22 · 2013: 6
FWCI: 2.90
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by-nc/2.0 (unspecified)
Locations: Current Gastroenterology Reports (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: U.S. Food and Drug Administration
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: fecal microbiota transplantation, Clostridium difficile infection, gut dysbiosis, gut microbiota, inflammatory bowel disease, ulcerative colitis, irritable bowel syndrome, obesity, diabetes mellitus, donor selection, route of administration
MeSH terms: Biological Therapy, Enterocolitis, Pseudomembranous, Feces, Humans, Inflammatory Bowel Diseases, Evidence-Based Medicine, Gastrointestinal Tract, Irritable Bowel Syndrome, Microbiota

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Fecal Microbiota Transplantation: Indications, Methods, Evidence, and Future Directions

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