Cited by 180Antifungal resistance and susceptibilityFungal Infections and StudiesFungal and yeast genetics research

Efficacy of the Anti‐Candida rAls3p‐N or rAls1p‐N Vaccines against Disseminated and Mucosal Candidiasis

Spellberg, Brad J., Ibrahim, Ashraf S., Avanesian, Valentina, Fu, Yue, Myers, Carter, Phan, Quynh T., Filler, Scott G., Yeaman, Michael R. +1 more·2006·The Journal of Infectious Diseases

Abstract

We have shown that vaccination with the recombinant N terminus of Als1p (rAls1p-N) protects mice against disseminated and oropharyngeal candidiasis. We now report that vaccination of mice with a related candidate, rAls3p-N, induces a broader antibody response than rAls1p-N and a similar cell-mediated immune response. The rAls3p-N vaccine was equally as effective as rAls1p-N against disseminated candidiasis but was more effective than rAls1p-N against oropharyngeal or vaginal candidiasis. Antibody titers did not correlate with protection against disseminated candidiasis, but delayed-type hypersensitivity did. The rAls3p-N vaccine is a promising new vaccine candidate for further exploration to prevent systemic and mucosal candidal infections.

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Crossref · 10.1086/504691

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  • Vaccination of mice with rAls3 provides significant protection from lethal hematogenously disseminated candidiasis and ameliorates the course of oropharyngeal and vaginal candidiasis.

    “However, we have found that vaccination of mice with rAls3 provides significant protection from lethal hematogenously disseminated candidiasis and ameliorates the course of oropharyngeal and vaginal candidiasis [40].”

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Authors
Spellberg, B. J., Ibrahim, A. S., Avanesian, V., Fu, Y., Myers, C., Phan, Q. T., Filler, S. G., Yeaman, M. R., & Edwards, Jr.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Spellberg, Brad J.
Venue
The Journal of Infectious Diseases
Published
2006-07-15
Volume
194
Issue
2
Pages
256-260
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2098726188
Cited by
180
References
15
Citations by year
2026: 2 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 16 · 2021: 10 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 16 · 2016: 8 · 2015: 7 · 2014: 18 · 2013: 5 · 2012: 15
FWCI
4.96
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (R01 A1054928)
  • National Institute of Allergy and Infectious Diseases (R01AI019990, R01 AI-48031, K08AI060641, AI-063382, R01-AI19990, R01AI048031, R01AI063382, R56AI063503, R56 AI63503-01A1)
  • National Institute of Dental and Craniofacial Research (R01DE017088, DE017088)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Candida albicans, recombinant protein vaccine, systemic candidiasis, oropharyngeal candidiasis, vaginal candidiasis, mucosal candidiasis, antibody response, cell-mediated immunity, delayed-type hypersensitivity, vaccine efficacy
MeSH terms
Animals, Candida, Candidiasis, Female, Fungal Proteins, Fungal Vaccines, Mice, Inbred BALB C, Recombinant Proteins, Mice

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