Efficacy of the Anti‐Candida rAls3p‐N or rAls1p‐N Vaccines against Disseminated and Mucosal Candidiasis
Abstract
We have shown that vaccination with the recombinant N terminus of Als1p (rAls1p-N) protects mice against disseminated and oropharyngeal candidiasis. We now report that vaccination of mice with a related candidate, rAls3p-N, induces a broader antibody response than rAls1p-N and a similar cell-mediated immune response. The rAls3p-N vaccine was equally as effective as rAls1p-N against disseminated candidiasis but was more effective than rAls1p-N against oropharyngeal or vaginal candidiasis. Antibody titers did not correlate with protection against disseminated candidiasis, but delayed-type hypersensitivity did. The rAls3p-N vaccine is a promising new vaccine candidate for further exploration to prevent systemic and mucosal candidal infections.
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Vaccination of mice with rAls3 provides significant protection from lethal hematogenously disseminated candidiasis and ameliorates the course of oropharyngeal and vaginal candidiasis.
“However, we have found that vaccination of mice with rAls3 provides significant protection from lethal hematogenously disseminated candidiasis and ameliorates the course of oropharyngeal and vaginal candidiasis [40].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [40]
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Self-citation
- Authors
- Spellberg, B. J., Ibrahim, A. S., Avanesian, V., Fu, Y., Myers, C., Phan, Q. T., Filler, S. G., Yeaman, M. R., & Edwards, Jr.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Spellberg, Brad J.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-15
- Volume
- 194
- Issue
- 2
- Pages
- 256-260
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2098726188
- Cited by
- 180
- References
- 15
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 16 · 2021: 10 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 16 · 2016: 8 · 2015: 7 · 2014: 18 · 2013: 5 · 2012: 15
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (R01 A1054928)
- National Institute of Allergy and Infectious Diseases (R01AI019990, R01 AI-48031, K08AI060641, AI-063382, R01-AI19990, R01AI048031, R01AI063382, R56AI063503, R56 AI63503-01A1)
- National Institute of Dental and Craniofacial Research (R01DE017088, DE017088)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida albicans, recombinant protein vaccine, systemic candidiasis, oropharyngeal candidiasis, vaginal candidiasis, mucosal candidiasis, antibody response, cell-mediated immunity, delayed-type hypersensitivity, vaccine efficacy
- MeSH terms
- Animals, Candida, Candidiasis, Female, Fungal Proteins, Fungal Vaccines, Mice, Inbred BALB C, Recombinant Proteins, Mice
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