Diagnostic accuracy of behavioral variant frontotemporal dementia consortium criteria (FTDC) in a clinicopathological cohort
Abstract
Aims: The aims of this study were to assess the sensitivity of the I nternational B ehavioural V ariant FTD C riteria C onsortium ( FTDC ) revised criteria of behavioural variant frontotemporal dementia ( bvFTD ) in a pathological cohort and to determine their predictive values in a clinical context suggestive of bvFTD . In addition, the study aimed to assess the influence of the age at onset and underlying pathology in the clinicopathological correlations. Methods: Retrospective, blinded review of the clinical and neuropathological data from the N eurological T issue B ank of the B iobank H ospital C linic– IDIBAPS , B arcelona ( S pain) was conducted, assessing the fulfilment of the diagnostic criteria on a case‐by‐case basis. Two separate nonexclusive cohorts were selected: Cohort 1 ( n = 58) subjects with pathological diagnosis of frontotemporal lobar degeneration ( FTLD ) and Cohort 2 ( n = 66) subjects with the premortem diagnosis of bvFTD . Results: The FTDC criteria reached a sensitivity of 93% for possible and 80% for probable bvFTD . Early‐onset cases displayed significantly more disinhibition, loss of empathy and compulsive behaviour with respect to late‐onset bvFTD , leading to a slightly higher sensitivity of the diagnostic criteria (97% vs. 91%). There were no differences in the diagnostic performance between tau‐positive and tau‐negative cases. In subjects clinically diagnosed as bvFTD , a ‘possible bvFTD ’ diagnosis reached a positive predictive value for FTLD pathology of 90%, irrespective of underlying proteinopathy. False‐positive clinical diagnoses were mainly A lzheimer's disease. These cases were significantly older, had less family history of dementia and had a predominantly apathetic clinical picture. Conclusions: The revised bvFTD criteria present good sensitivity and positive predictive value in both early‐ and late‐onset cases and regardless of the underlying FTLD pathology.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The overlap of clinical features in bvFTD or svPPA with those observed in AD or psychiatric disorders represents additional challenges for clinical diagnosis.
“Furthermore, the overlap of clinical features in bvFTD or svPPA with those observed in AD or psychiatric disorders represents additional challenges for clinical diagnosis.”
From New developments of biofluid‐based biomarkers for routine diagnosis and disease trajectories in frontotemporal dementia (2022) · cites this paper as [11]
Cites
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Beach, T. G., Monsell, S. E., Phillips, L. E., & Kukull, W. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31824b211b · Cited by 1,103 · see citing works
A harmonized classification system for FTLD-TDP pathology
Mackenzie, I. R., Neumann, M., Baborie, A., Sampathu, D. M., du Plessis, D., Jaros, E., Perry, R. H., Trojanowski, J. Q., Mann, D. M. A., & Lee, V. M. ‐. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0845-8 · Cited by 1,013 · see citing works
Mackenzie, I. R. A., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I., Kril, J., Kovacs, G. G., Ghetti, B., Halliday, G., Holm, I. E., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0612-2 · Cited by 1,012 · see citing works
Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Fleisher, A. S., Reiman, E. M., Sabbagh, M. N., Sadowsky, C. H., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70142-4 · Cited by 855 · see citing works
Focal cortical presentations of Alzheimer's disease
Alladi, S., Xuereb, J., Bak, T., Nestor, P., Knibb, J., Patterson, K., & Hodges, J. R. (2007) · Brain · doi:10.1093/brain/awm213 · Cited by 581 · see citing works
Frontotemporal dementia: Clinicopathological correlations
Forman, M. S., Farmer, J., Johnson, J. K., Clark, C. M., Arnold, S. E., Coslett, H. B., Chatterjee, A., Hurtig, H. I., Karlawish, J. H., Rosen, H. J., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20873 · Cited by 478 · see citing works
Clinical and Pathological Evidence for a Frontal Variant of Alzheimer Disease
Johnson, J. K., Head, E., Kim, R., Starr, A., & Cotman, C. W. (1999) · Archives of Neurology · doi:10.1001/archneur.56.10.1233 · Cited by 414 · see citing works
Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics
Whitwell, J. L., Weigand, S. D., Boeve, B. F., Senjem, M. L., Gunter, J. L., DeJesus-Hernandez, M., Rutherford, N. J., Baker, M., Knopman, D. S., Wszolek, Z. K., et al. (2012) · Brain · doi:10.1093/brain/aws001 · Cited by 397 · see citing works
Finch, N. A., Baker, M., Crook, R., Swanson, K. R., Kuntz, K., Surtees, R., Bisceglio, G. D., Rovelet‐Lecrux, A., Boeve, B. F., Petersen, R. C., et al. (2009) · Brain · doi:10.1093/brain/awn352 · Cited by 382 · see citing works
Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
Rohrer, J. D., Lashley, T., Schott, J. M., Warren, J. D., Mead, S., Isaacs, A. M., Beck, J. A., Hardy, J., de Silva, R., Warrington, E. K., et al. (2011) · Brain · doi:10.1093/brain/awr198 · Cited by 359 · see citing works
Boeve, B. F., Boylan, K., Graff‐Radford, N. R., DeJesus‐Hernandez, M., Knopman, D. S., Pedraza, O., Vemuri, P., Jones, D. T., Lowe, V. J., Murray, M. E., et al. (2012) · Brain · doi:10.1093/brain/aws004 · Cited by 344 · see citing works
Whitwell, J. L., Przybelski, S. A., Weigand, S. D., Ivnik, R. J., Vemuri, P., Gunter, J. L., Senjem, M. L., Shiung, M. M., Boeve, B. F., Knopman, D. S., et al. (2009) · Brain · doi:10.1093/brain/awp232 · Cited by 306 · see citing works
Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
Schoonenboom, N. S. M., Reesink, F. E., Verwey, N. A., Kester, M. I., Teunissen, C. E., van de Ven, P. M., Pijnenburg, Y. A. L., Blankenstein, M. A., Rozemuller, A. J., Scheltens, P., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31823ed0f0 · Cited by 302 · see citing works
van der Zee, J., Gijselinck, I., Dillen, L., Langenhove, T. V., Theuns, J., Engelborghs, S., Philtjens, S., Vandenbulcke, M., Sleegers, K., Sieben, A., et al. (2012) · Human Mutation · doi:10.1002/humu.22244 · Cited by 266 · see citing works
Self-citationRademakers, R., Baker, M. C., Gass, J. M., Adamson, J. L., Huey, E. D., Momeni, P., Spina, S., Coppola, G., Karydas, A. M., Stewart, H. G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70221-1 · Cited by 211 · see citing works
Accuracy of the Clinical Evaluation for Frontotemporal Dementia
Mendez, M. F., Shapira, J. S., McMurtray, A. M., Licht, E. A., & Miller, B. L. (2007) · Archives of Neurology · doi:10.1001/archneur.64.6.830 · Cited by 205 · see citing works
Pathologically proven frontotemporal dementia presenting with severe amnesia
Graham, A. (2005) · Brain · doi:10.1093/brain/awh348 · Cited by 203 · see citing works
How preserved is episodic memory in behavioral variant frontotemporal dementia?
Hornberger, M., Piguet, O., Graham, A. J., Nestor, P. J., & Hodges, J. R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cef85d · Cited by 202 · see citing works
Eating and hypothalamus changes in behavioral‐variant frontotemporal dementia
Piguet, O., Petersén, Å., Lam, B. Y. K., Gabery, S., Murphy, K., Hodges, J. R., & Halliday, G. M. (2010) · Annals of Neurology · doi:10.1002/ana.22244 · Cited by 192 · see citing works
TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia
Rohrer, J. D., Geser, F., Zhou, J., Gennatas, E. D., Sidhu, M., Trojanowski, J. Q., DeArmond, S. J., Miller, B. L., & Seeley, W. W. (2010) · Neurology · doi:10.1212/wnl.0b013e318202038c · Cited by 187 · see citing works
Khan, B. K., Yokoyama, J. S., Takada, L. T., Sha, S. J., Rutherford, N. J., Fong, J. C., Karydas, A. M., Wu, T., Ketelle, R. S., Baker, M. C., et al. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301883 · Cited by 185 · see citing works
Prominent phenotypic variability associated with mutations in Progranulin
Kelley, B. J., Haidar, W. N., Boeve, B. F., Baker, M. C., Graff‐Radford, N. R., Krefft, T. A., Frank, A. R., Jack, C. R., Shiung, M. S., Knopman, D. S., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.022 · Cited by 181 · see citing works
Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease
Balasa, M., Gelpí, E., Antonell, A., Rey, M. J., Sánchez‐Valle, R., Molinuevo, J. L., & Lladó, A. (2011) · Neurology · doi:10.1212/wnl.0b013e31821a44dd · Cited by 154 · see citing works
Self-citationSensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia
Piguet, O., Hornberger, M., Shelley, B. P., Kipps, C., & Hodges, J. R. (2009) · Neurology · doi:10.1212/01.wnl.0000343004.98599.45 · Cited by 102 · see citing works
Clinicopathologic differences among patients with behavioral variant frontotemporal dementia
Mendez, M. F., Joshi, A., Tassniyom, K., Teng, E., & Shapira, J. S. (2013) · Neurology · doi:10.1212/wnl.0b013e3182815547 · Cited by 96 · see citing works
Sensitivity and specificity of FTDC criteria for behavioral variant frontotemporal dementia
Harris, J. M., Gall, C., Thompson, J. C., Richardson, A. M. T., Neary, D., du Plessis, D., Pal, P., Mann, D. M. A., Snowden, J. S., & Jones, M. (2013) · Neurology · doi:10.1212/wnl.0b013e318292a342 · Cited by 83 · see citing works
Pathological correlates of frontotemporal lobar degeneration in the elderly
Baborie, A., Griffiths, T. D., Jaros, E., McKeith, I. G., Burn, D. J., Richardson, A. M. T., Ferrari, R., Moreno, J. H., Momeni, P., DuPlessis, D., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0765-z · Cited by 78 · see citing works
Frontotemporal Dementia in Elderly Individuals
Baborie, A., Griffiths, T. D., Jaros, E., Momeni, P., McKeith, I. G., Burn, D. J., Keir, G., Larner, A. J., Mann, D. M. A., & Perry, R. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.3323 · Cited by 58 · see citing works
Pijnenburg, Y. A. L., Mulder, J., Swieten, J. C. V., Uitdehaag, B. M. J., Stevens, M., Scheltens, P., & Jonker, C. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000112852 · Cited by 47 · see citing works
Lladó, A., Sánchez‐Valle, R., Rey, M. J., Ezquerra, M., TOLOSA, E. S., Ferrer, I., Molinuevo, J. L., & for the Catalan collaborative Study Group for FTLD* (2008) · Journal of Neurology · doi:10.1007/s00415-008-0565-8 · Cited by 42 · see citing works
Self-citationUsefulness of Biomarkers in the Diagnosis and Prognosis of Early-Onset Cognitive Impairment
Balasa, M., Sánchez‐Valle, R., Antonell, A., Bosch, B., Olives, J., Rami, L., Castellvı́, M., Molinuevo, J. L., & Lladó, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132195 · Cited by 38 · see citing works
Self-citationClinical features of pathologic subtypes of behavioral--variant frontotemporal dementia.
Hu, W. T., Mandrekar, J., Parisi, J., Knopman, D., Boeve, B., Petersen, R., Hutton, M., Dickson, D., & Josephs, K. (2007) · Archives of Neurology · doi:10.1001/archneur.64.11.1611 · Cited by 35 · see citing works
Antonell, A., Gil, S., Sánchez‐Valle, R., Balasa, M., Bosch, B., Prat, M. C., Chiollaz, A.-C., Fernández, M., Yagüe, J., Molinuevo, J. L., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112120 · Cited by 31 · see citing works
Self-citationGelpí, E., Lladã, A., Clarimón, J., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318266efb1 · Cited by 18 · see citing works
Self-citationComparison of 2 Diagnostic Criteria for the Behavioral Variant of Frontotemporal Dementia
Costa, S., Suárez‐Calvet, M., Antón‐Aguirre, S., Dols‐Icardo, O., Clarimón, J., Alcolea, D. A., Fortea, J., Carmona‐Iragui, M., Sala, I., Sánchez‐Saudinós, M. B., et al. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513488918 · Cited by 12 · see citing works
Karve, S. J., Teng, E., Tassniyom, K., & Mendez, M. F. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513505134 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
del Campo, M., Zetterberg, H., Gandy, S., Onyike, C. U., Oliveira, F., Udeh‐Momoh, C., Lleó, A., Teunissen, C. E., & Pijnenburg, Y. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12643 · Cited by 52 · see citing works
Vijverberg, E. G. B., Dols, A., Krudop, W. A., Peters, A., Kerssens, C. J., van Berckel, B. N. M., Wattjes, M. P., Barkhof, F., Gossink, F., Prins, N. D., et al. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000444849 · Cited by 40 · see citing works
Gossye, H., Van Broeckhoven, C., & Engelborghs, S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00757 · Cited by 34 · see citing works
Marelli, C., Hourregue, C., Gutierrez, L.-A., Paquet, C., Menjot de Champfleur, N., De Verbizier, D., Jacob, M., Dubois, J., Maleska, A. M., Hirtz, C., et al. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-190378 · Cited by 21 · see citing works
- Authors
- Balasa, M., Gelpi, E., Martín, I., Antonell, A., Rey, M. J., Grau‐Rivera, O., Molinuevo, J. L., Sánchez‐Valle, R., Lladó, A., & Catalan collaborative Study Group for FTLD
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Neurological Tissue Bank of the Biobank Hospital Clínic Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Clínic Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain
- Corresponding author
- Sánchez‐Valle, Raquel
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2015-05-02
- Volume
- 41
- Issue
- 7
- Pages
- 882-892
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1774607075
- Cited by
- 32
- References
- 38
- Citations by year
- 2025: 2 · 2024: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 6 · 2015: 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- La Fundació Marató TV3 2013
- Fundación Tatiana Perez de Guzmán el Bueno 2013
- Spanish Ministry of Health (FIS PI11/00234)
- Spanish Ministerio de Economía y Competividad programa (PTA 2011)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- behavioral variant frontotemporal dementia, diagnostic accuracy, sensitivity, positive predictive value, frontotemporal lobar degeneration, clinicopathological correlation, age of onset, tau pathology, proteinopathies, disinhibition, loss of empathy, compulsive behaviour, neuropathology
- MeSH terms
- Adult, Aged, Aged, 80 and over, Brain, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Retrospective Studies, Age of Onset, Biological Specimen Banks, Frontotemporal Lobar Degeneration, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
