Cerebrospinal Fluid and Plasma Biomarkers do not Differ in the Presenile and Late-Onset Behavioral Variants of Frontotemporal Dementia
Open accessAbstract
BACKGROUND: Memory troubles and hippocampal atrophy are considered more frequent and focal atrophy less severe in late-onset (>65 years) than in presenile behavioral variant of frontotemporal dementia (bvFTD). OBJECTIVE: To compare cerebrospinal fluid (CSF) and plasma biomarkers in late-onset and presenile bvFTD. METHODS: Multicentric retrospective study (2007-2017) on patients with clinical diagnosis of bvFTD. RESULTS: This study included 44 patients (67%) with presenile and 22 (33%) with late-onset bvFTD (comparable mean disease duration; n = 11 with causal mutations). Hippocampal atrophy was more frequent (80% versus 25.8%) and severe in late-onset bvFTD (median Scheltens score: 3 [0-4] versus 1 [0-3]), without difference after adjustment for age. Lobar atrophy and focal hypometabolism/hypoperfusion were not different between groups. The median CSF Aβ1-42 and phosphorylated tau (P-tau) concentrations were in the normal range and comparable between groups. Axonal neurodegeneration biomarkers were within the normal range (CSF T-tau; plasma T-tau in late-onset bvFTD) or higher (plasma neurofilament light chain (NFL); plasma T-tau in presenile bvFTD) than the normal values, but globally not different between bvFTD groups. Plasma glial fibrillary acid protein (GFAP) was strongly increased in both bvFTD groups compared with the values in controls of the same age. CONCLUSION: The CSF and plasma biomarker profiles did not suggest a more aggressive neurodegeneration in the presenile group (comparable T-tau, NFL, and GFAP levels) or the co-existence of Alzheimer's disease in the late-onset group (comparable and within normal range CSF Aβ1-42 and P-tau). The severity of the neurodegenerative process seems comparable in presenile and late-onset bvFTD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some studies reported elevated blood GFAP in participants with FTD compared to controls.
“Indeed, some studies reported elevated blood GFAP in participants with FTD compared to controls [8–18] but others observed no such GFAP increase in FTD [19–22].”
From Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders (2025) · cites this paper as [10]
Cites
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging
Fazekas, F., Chawluk, J. B., Alavi, A. A., Hurtig, H. I., & Zimmerman, R. A. (1987) · American Journal of Roentgenology · doi:10.2214/ajr.149.2.351 · Cited by 5,327 · see citing works
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Olsson, B., Lautner, R., Andreasson, U., Öhrfelt, A., Portelius, E., Bjerke, M., Hölttä, M., Rosén, C., Olsson, C., Strobel, G., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00070-3 · Cited by 2,049 · see citing works
A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Feldman, H. H., Frisoni, G. B., Hampel, H., Jagust, W. J., Johnson, K. A., Knopman, D. S., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002923 · Cited by 1,864 · see citing works
Scheltens, P., Leys, D., Barkhof, F., Huglo, D. G., Weinstein, H. C., Vermersch, P., Kuiper, M. A., Steinling, M., Wolters, E. C., & Valk, J. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.10.967 · Cited by 1,781 · see citing works
Screening for dementia by memory testing
Grober, E. H., Herman Buschke, L., Crystal, H., Bang, S., & Dresner, R. (1988) · Neurology · doi:10.1212/wnl.38.6.900 · Cited by 956 · see citing works
Improved discrimination of AD patients using β-amyloid <sub>(1-42)</sub> and tau levels in CSF
Hulstaert, F., Blennow, K., Ivanoiu, A., Schoonderwaldt, H. C., Riemenschneider, M., Deyn, P. P. D., Bancher, C., Cras, P., Wiltfang, J., Mehta, P. D., et al. (1999) · Neurology · doi:10.1212/wnl.52.8.1555 · Cited by 724 · see citing works
Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
Rohrer, J. D., Woollacott, I., Dick, K. M., Brotherhood, E., Gordón, E., Fellows, A. D., Toombs, J., Druyeh, R., Cardoso, M. J., Sebastien Ourselin, A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003154 · Cited by 431 · see citing works
Visual assessment of posterior atrophy development of a MRI rating scale
Koedam, E., Lehmann, M., van der Flier, W. M., Scheltens, P., Pijnenburg, Y. A. L., Fox, N. C., Barkhof, F., & Wattjes, M. P. (2011) · European Radiology · doi:10.1007/s00330-011-2205-4 · Cited by 410 · see citing works
Neurofilament light chain: a biomarker for genetic frontotemporal dementia
Meeter, L. H., Dopper, E. G., Jiskoot, L. C., Sanchez‐Valle, R., Graff, C., Benussi, L., Ghidoni, R., Pijnenburg, Y. A., Borroni, B., Galimberti, D., et al. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.325 · Cited by 263 · see citing works
Magnetic Resonance Imaging Signal Hyperintensities in the Deep and Subcortical White Matter
Schmidt, R. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530320049011 · Cited by 246 · see citing works
Ishiki, A., Kamada, M., Kawamura, Y., Terao, C., Shimoda, F., Tomita, N., Arai, H., & Furukawa, K. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13399 · Cited by 156 · see citing works
Wallon, D., The collaborators of the GMAJ project, Rousseau, S., Rovelet‐Lecrux, A., Quillard‐Muraine, M., Guyant‐Maréchal, L., Martinaud, O., Pariente, J., Puel, M., Rollin‐Sillaire, A., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120172 · Cited by 124 · see citing works
Self-citationClinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum
Meeter, L. H. H., Vijverberg, E. G., Del Campo, M., Rozemuller, A. J. M., Donker Kaat, L., de Jong, F. J., van der Flier, W. M., Teunissen, C. E., van Swieten, J. C., & Pijnenburg, Y. A. L. (2018) · Neurology · doi:10.1212/wnl.0000000000005261 · Cited by 122 · see citing works
Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease
Cho, H., Jeon, S., Kang, S. J., Lee, J. M., Lee, J., Kim, G. H., Shin, J. S., Kim, C. H., Noh, Y., Im, K., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.004 · Cited by 106 · see citing works
Sensitivity and specificity of FTDC criteria for behavioral variant frontotemporal dementia
Harris, J. M., Gall, C., Thompson, J. C., Richardson, A. M. T., Neary, D., du Plessis, D., Pal, P., Mann, D. M. A., Snowden, J. S., & Jones, M. (2013) · Neurology · doi:10.1212/wnl.0b013e318292a342 · Cited by 83 · see citing works
Pathological correlates of frontotemporal lobar degeneration in the elderly
Baborie, A., Griffiths, T. D., Jaros, E., McKeith, I. G., Burn, D. J., Richardson, A. M. T., Ferrari, R., Moreno, J. H., Momeni, P., DuPlessis, D., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0765-z · Cited by 78 · see citing works
Impact of harmonization of collection tubes on Alzheimer's disease diagnosis
Lehmann, S., Schraen‐Maschke, S., Quadrio, I., Paquet, C., Bombois, S., Delaby, C., Dorey, A., Dumurgier, J., Hirtz, C., Krolak‐Salmon, P., et al. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.06.008 · Cited by 73 · see citing works
Self-citationTeunissen, C. E., Verwey, N. A., Kester, M. I., van Uffelen, K. W. J., & Blankenstein, M. A. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/635053 · Cited by 70 · see citing works
Frontotemporal Dementia in Elderly Individuals
Baborie, A., Griffiths, T. D., Jaros, E., Momeni, P., McKeith, I. G., Burn, D. J., Keir, G., Larner, A. J., Mann, D. M. A., & Perry, R. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.3323 · Cited by 58 · see citing works
Cognitive Function and Psychiatric Symptoms in Early- and Late-Onset Frontotemporal Dementia
Shinagawa, S., Toyota, Y., Ishikawa, T., Fukuhara, R., Hokoishi, K., Komori, K., Tanimukai, S., & Ikeda, M. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000124751 · Cited by 34 · see citing works
Balasa, M., Gelpi, E., Martín, I., Antonell, A., Rey, M. J., Grau‐Rivera, O., Molinuevo, J. L., Sánchez‐Valle, R., Lladó, A., & Catalan collaborative Study Group for FTLD (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12194 · Cited by 32 · see citing works
Ye, B. S., Choi, S. H., Han, S., Kim, S., Yang, D., Park, K. H., Han, H. J., Youn, Y. C., Choi, B., Kim, S. H., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141044 · Cited by 24 · see citing works
Imagerie cérébrale du vieillissement normal : contraste avec la maladie d’Alzheimer
Desgranges, B., Kalpouzos, G., & Eustache, F. (2008) · Revue Neurologique · doi:10.1016/s0035-3787(08)73299-5 · Cited by 22 · see citing works
Is early‐onset clinically different from late‐onset frontotemporal dementia?
Borroni, B., Agosti, C., Bellelli, G., & Padovani, A. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02338.x · Cited by 22 · see citing works
Marelli, C., Gutierrez, L., de Champfleur, N. M., Charroud, C., de Verbizier, D., Touchon, J., Douillet, P., Berr, C., Lehmann, S., & Gabelle, A. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.06.004 · Cited by 18 · see citing works
Self-citationExacerbated CSF abnormalities in younger patients with Alzheimer's disease
Dumurgier, J., Gabelle, A., Vercruysse, O., Bombois, S., Laplanche, J., Peoc’h, K., Schraen‐Maschke, S., Sablonnière, B., Pasquier, F., Touchon, J., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.01.023 · Cited by 16 · see citing works
Self-citationBaborie, A., Griffiths, T. D., Jaros, E., Momeni, P., McKeith, I. G., Burn, D. J., Keir, G., Larner, A. J., Mann, D. M. A., & Perry, R. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1649 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Benussi, A., Ashton, N. J., Karikari, T. K., Gazzina, S., Premi, E., Benussi, L., Ghidoni, R., Rodriguez, J. L., Emeršič, A., Binetti, G., et al. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-200608 · Cited by 113 · see citing works
Oeckl, P., Anderl-Straub, S., Von Arnim, C. A. F., Baldeiras, I., Diehl-Schmid, J., Grimmer, T., Halbgebauer, S., Kort, A. M., Lima, M., Marques, T. M., et al. (2022) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-328547 · Cited by 94 · see citing works
Shen, X., Huang, S., Cui, M., Zhao, Q., Guo, Y., Huang, Y., Zhang, W., Ma, Y., Chen, S.-D., Zhang, Y.-R., et al. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvad018 · Cited by 96 · see citing works
Zhu, N., Santos-Santos, M., Illán-Gala, I., Montal, V., Estellés, T., Barroeta, I., Altuna, M., Arranz, J., Muñoz, L., Belbin, O., et al. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00275-w · Cited by 86 · see citing works
Katisko, K., Cajanus, A., Huber, N., Jääskeläinen, O., Kokkola, T., Kärkkäinen, V., Rostalski, H., Hartikainen, P., Koivisto, A. M., Hannonen, S., et al. (2021) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-326487 · Cited by 65 · see citing works
Blood biomarkers in frontotemporal dementia: Review and meta-analysis
Ntymenou, S., Tsantzali, I., Kalamatianos, T., Voumvourakis, K. I., Kapaki, E., Tsivgoulis, G., Stranjalis, G., & Paraskevas, G. P. (2021) · Brain Sciences · doi:10.3390/brainsci11020244 · Cited by 31 · see citing works
Chitranshi, N., Kumar, A., Sheriff, S., Gupta, V. B., Godinez, A., Saks, D., Sarkar, S., Shen, T., Mirzaei, M., Basavarajappa, D. K., et al. (2021) · Cells · doi:10.3390/cells10081946 · Cited by 29 · see citing works
Biomarkers in frontotemporal dementia: Current landscape and future directions
Gifford, A., Praschan, N. C., Newhouse, A. L., & Chemali, Z. N. (2023) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2023.100065 · Cited by 26 · see citing works
Sheth, U., Öijerstedt, L., Heckman, M. G., White, L. J., Heuer, H. W., Lario Lago, A., Forsberg, L. K., Faber, K. M., Foroud, T. M., Rademakers, R., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00821-4 · Cited by 20 · see citing works
Blood-Based Biomarkers in Frontotemporal Dementia: A Narrative Review
Liampas, I., Kyriakoulopoulou, P., Karakoida, V., Kavvoura, P. A., Sgantzos, M. N., Bogdanos, D. P., Stamati, P., Dardiotis, E., & Siokas, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111838 · Cited by 26 · see citing works
Eratne, D., Kang, M. J., Lewis, C., Dang, C., Malpas, C. B., Ooi, S., Brodtmann, A. G., Darby, D., Zetterberg, H., Blennow, K., et al. (2024) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2024.123291 · Cited by 20 · see citing works
Predicting neurodegeneration from sleep related biofluid changes
Yang, Y., Kim, W. S., Michaelian, J. C., Lewis, S. J. G., Phillips, C. L., D'Rozario, A. L., Chatterjee, P., Martins, R. N., Grunstein, R. R., Halliday, G. M., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106369 · Cited by 10 · see citing works
Han, X., & Guo, K. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1412349 · Cited by 3 · see citing works
Hanin, A., Quadrio, I., Beaudeux, J., & Lamari, F. (2026) · Journal of Neurology · doi:10.1007/s00415-026-13896-w · Cited by 2 · see citing works
Profit vs. nonprofit: does either have a competitive edge?
Mangan, D. (1998) · PubMed · Cited by 1 · see citing works
Fluid and Imaging Markers of Frontotemporal Lobar Degeneration
Prinse, F., Houwer, J. F. H. D., Dopper, E. G. P., & Seelaar, H. (2025) · Springer eBooks · doi:10.1007/978-3-031-80849-4_9 · Cited by 1 · see citing works
Zhu, N., Santos‐Santos, M., Illán‐Gala, I., Montal, V., Estellés, T., Barroeta, I., Altuna, M., Arranz, J., Muñoz, L., Belbin, O., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-958956/v1
Upadhyay, K. D., Viramgami, A., Singh, D., Kulkarni, N., Chudasama, B., Sivaperumal, P., & Balachandar, R. (2025) · Research Square · doi:10.21203/rs.3.rs-7788186/v1
Zhu, N., Santos‐Santos, M., Illán‐Gala, I., Montal, V., Estellés, T., Barroeta, I., Altuna, M., Arranz, J., Muñoz, L., Belbin, O., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17161621
Zhu, N., Santos‐Santos, M., Illán‐Gala, I., Montal, V., Estellés, T., Barroeta, I., Altuna, M., Arranz, J., Muñoz, L., Belbin, O., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17161618
- Authors
- Marelli, C., Hourregue, C., Gutierrez, L.-A., Paquet, C., Menjot de Champfleur, N., De Verbizier, D., Jacob, M., Dubois, J., Maleska, A. M., Hirtz, C., Navucet, S., Bennys, K., Dumurgier, J., Cognat, E., Berr, C., Magnin, E., Lehmann, S., & Gabelle, A.
- Affiliations
- Memory Research and Resources Alzheimer Center, Department of Neurology, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France
- Inserm (FR)
- Université Paris Cité (FR)
- Institut d’Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France
- Department of Nuclear Medicine, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France
- Centre Hospitalier Universitaire de Montpellier (FR)
- Department of Neurology, Centre Mémoire Ressources Recherche Besançon Franche-Comté, CHU de Besançon, Besançon, France
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2020-04-07
- Volume
- 74
- Issue
- 3
- Pages
- 903-911
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W3008029228
- Cited by
- 21
- References
- 28
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 8 · 2020: 1
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- behavioral variant frontotemporal dementia
- MeSH terms
- Adult, Aged, Aged, 80 and over, Brain, Female, Glial Fibrillary Acidic Protein, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Peptide Fragments, Retrospective Studies, Biomarkers, Amyloid beta-Peptides, tau Proteins, Age of Onset, Positron-Emission Tomography, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
