High amplitude propagated contractions
Open accessAbstract
While most colonic motor activity is segmental and non‐propulsive, colonic high amplitude propagated contractions (HAPC) can transfer colonic contents over long distances and often precede defecation. High amplitude propagated contractions occur spontaneously, in response to pharmacological agents or colonic distention. A subset of patients with slow transit constipation have fewer HAPC. In this issue of Neurogastroenterology and Motility, Rodriguez et al.report that anal relaxation during spontaneous and bisacodyl‐induced HAPC exceeds anal relaxation during rectal distention in constipated children undergoing colonic manometry. Moreover, and consistent with a neural mechanism, anal relaxation often precedes arrival of HAPC in the left colon. High amplitude propagated contractions are also used to evaluate the motor response to a meal and pharmacological stimuli (e.g., bisacodyl, neostigmine) and to identify colonic inertia during colonic motility testing in chronic constipation. This editorial comprehensively reviews the characteristics, physiology and pharmacology of HAPC, their assessment by manometry, and relevance to constipation and diarrhea.
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High-amplitude propagated contractions propagate colonic contents.
“Such highamplitude propagated contractions propagate colonic contents. 83”
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Integrated responses of the SIP syncytium generate a major motility pattern in the colon
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Usefulness of Bisacodyl Testing on Therapeutic Outcomes in Refractory Constipation
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Physiology of the Colon and Its Measurement
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A Study of risk factors of postoperative ileus after laparoscopic colorectal resection
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Neurophysiologic Mechanisms of Human Large Intestinal Motility ☆
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A model for gastrointestinal tract motility in a 4D imaging phantom of human anatomy
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Motility of the Small Intestine and Colon
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Colonic Inertia: approach and treatment
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Physiology of the Colon and Its Measurement
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Self-citationIntestine motility, secretion, and constipation treatment principles
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Translumbosacral Neuromodulation Therapy Is a Promising Option for Fecal Incontinence
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Transient Anal Sphincter Relaxations Are a Normal Phenomenon in Healthy Subjects
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- Authors
- Bharucha, A. E.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Bharucha, A. E.
- ORCID
- Bharucha, A. E.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2012-10-11
- Volume
- 24
- Issue
- 11
- Pages
- 977-982
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- PMC
- PMC3471560
- OpenAlex
- W1911298215
- Cited by
- 119
- References
- 52
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 23 · 2022: 6 · 2021: 8 · 2020: 14 · 2019: 17 · 2018: 12 · 2017: 8 · 2016: 14 · 2015: 4 · 2014: 4 · 2013: 2
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (R01 DKDK78924)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK068055, R01DK078924, P01-DK-68055)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Keywords
- colonic motility, slow transit constipation, colonic manometry, bisacodyl, neostigmine, colonic distension, defecation, diarrhea
- MeSH terms
- Constipation, Gastrointestinal Motility, Humans, Muscle Contraction, Muscle, Smooth
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