Cited by 119Gastrointestinal motility and disordersCongenital gastrointestinal and neural anomaliesPelvic floor disorders treatments

High amplitude propagated contractions

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Bharucha, A. E.·2012·Neurogastroenterology & Motility

Abstract

While most colonic motor activity is segmental and non‐propulsive, colonic high amplitude propagated contractions (HAPC) can transfer colonic contents over long distances and often precede defecation. High amplitude propagated contractions occur spontaneously, in response to pharmacological agents or colonic distention. A subset of patients with slow transit constipation have fewer HAPC. In this issue of Neurogastroenterology and Motility, Rodriguez et al.report that anal relaxation during spontaneous and bisacodyl‐induced HAPC exceeds anal relaxation during rectal distention in constipated children undergoing colonic manometry. Moreover, and consistent with a neural mechanism, anal relaxation often precedes arrival of HAPC in the left colon. High amplitude propagated contractions are also used to evaluate the motor response to a meal and pharmacological stimuli (e.g., bisacodyl, neostigmine) and to identify colonic inertia during colonic motility testing in chronic constipation. This editorial comprehensively reviews the characteristics, physiology and pharmacology of HAPC, their assessment by manometry, and relevance to constipation and diarrhea.

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  1. [9]Cook IJ Furukawa Y Panagopoulos V Collins PJ Dent J Relationships between spatial patterns of colonic pressure and individual movements of content American Journal of Physiology - Gastrointestinal & Liver Physiology 2000 278 G329 341 10666058

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Authors
Bharucha, A. E.
Affiliations
Mayo Clinic (US)
Corresponding author
Bharucha, A. E.
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2012-10-11
Volume
24
Issue
11
Pages
977-982
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
OpenAlex
W1911298215
Cited by
119
References
52
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 23 · 2022: 6 · 2021: 8 · 2020: 14 · 2019: 17 · 2018: 12 · 2017: 8 · 2016: 14 · 2015: 4 · 2014: 4 · 2013: 2
Type
journal article
Language
en
Open access
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Public Health Service (R01 DKDK78924)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P01DK068055, R01DK078924, P01-DK-68055)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
  • Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
Keywords
colonic motility, slow transit constipation, colonic manometry, bisacodyl, neostigmine, colonic distension, defecation, diarrhea
MeSH terms
Constipation, Gastrointestinal Motility, Humans, Muscle Contraction, Muscle, Smooth

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