The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Altered colonic function and microbiota profile in a mouse model of chronic depression
Open accessAbstract
Background: Depression often coexists with the irritable bowel syndrome (IBS) which is characterized by alterations in gut function. There is emerging evidence that the microbial composition (microbiota) of the gut is altered in IBS, but the basis for this is poorly understood. The aim of this study was to determine whether the induction of chronic depression results in changes in the colonic function and in its microbial community, and to explore underlying mechanisms. Methods: Bilateral olfactory bulbectomy (OB x) was used to induce depression‐like behavior in mice. Colonic function was assessed by measuring muscle contractility, pellet excretion, c‐fos activity, and serotonin levels. Microbiota profiles were obtained using denaturing gradient gel electrophoresis (DGGE). The hypothalamic‐pituitary axis (HPA) was assessed by the hypothalamic expression of corticotropin‐releasing hormone (CRH). In separate studies, mice without OB x received CRH via intracerebroventricular (ICV) infusion for 4 weeks prior to assessing colonic function and microbiota profiles. Key Results: Olfactory bulbectomy mice demonstrated chronic depression‐ and anxiety‐like behaviors associated with elevated central CRH expression and increases in c‐Fos activity, serotonin levels, and motility in the colon. These changes were accompanied by an altered intestinal microbial profile. Central CRH administration produced similar changes in behavior and motility and altered the microbiota profile in the colon. Conclusions & Inferences: The induction of chronic depression alters motor activity and the microbial profile in the colon likely via activation of the HPA. These findings provide a basis for linking the behavioral and gastrointestinal manifestations of IBS.
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The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540
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Metadata
- Authors
- Park, A. J., Collins, J., Blennerhassett, P. A., Ghia, J. E., Verdu, E. F., Bercik, P., & Collins, S. M.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2013-06-17
- Volume
- 25
- Issue
- 9
- Pages
- 733
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2012312828
- Cited by
- 293
- References
- 13
- FWCI
- 19.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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