The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity
Open accessAbstract
Background: Early adverse life events (EAL s) are associated with irritable bowel syndrome (IBS). Exposure to EAL s as assessed by the Adverse Childhood Experiences (ACE) questionnaire is associated with greater disease prevalence, but ACE has not been studied in gastrointestinal disorders. Study aims were to: (i) Estimate the prevalence of EAL s in the IBS patients using the ACE questionnaire; (ii) Determine correlations between ACE and Early Trauma Inventory Self Report‐Short Form (ETI‐SR) scores to confirm its validity in IBS; and (iii) Correlate ACE scores with IBS symptom severity. Methods: A total of 148 IBS (73% women, mean age = 31 years) and 154 HC s (59% women, mean age = 30 years) completed the ACE and ETI‐SR between June 2010 and April 2015. These surveys measured EAL s before age 18 in the domains of physical, sexual, and emotional abuse, and general trauma. IBS and abdominal pain severity was measured by a 20‐point scale (0 = none, 20 = worst symptoms). Key Results: The ACE score increased the odds of having IBS (odds ratio [OR] = 2.05, 95% confidence interval [CI]: 1.21–3.48, p = 0.008). Household mental illness (p < 0.001), emotional abuse (p = 0.004), and incarcerated household member (p = 0.019) were significant predictors of IBS. Adverse childhood experiences and ETI‐SR scores were strongly correlated (r = 0.59, p < 0.001). ACE, but not ETI‐SR, modestly correlated with IBS severity (r = 0.17, p = 0.036) and abdominal pain (r = 0.20, p = 0.015). Conclusions & Inferences: The ACE questionnaire is a useful instrument to measure EAL s in IBS based on its use in large studies, its ability to measure prevalence across different EAL domains, and its correlation with symptom severity.
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“Physically, childhood trauma has been associated with increased risk of cardiovascular disease (6), autoimmune disease (7), gastrointestinal symptoms (8), poor dental health (9), obesity, and type 2 diabetes (10).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [8]
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The microbiome-gut-brain axis in health and disease
Dinan, T. G., & Cryan, J. F. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.007 · Cited by 1,111
Pathophysiology of irritable bowel syndrome
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“, psychological trauma, inflammation, infection) are risk factors for GI inflammatory and functional diseases later in life (Bradford et al., 2012; Chaloner and Greenwood-Van Meerveld, 2013; Maccari et al., 2014; Park et al., 2016; Sanchez et al., 2001).”
BackgroundEpigenetic Modifications in Stress Response Genes Associated With Childhood Trauma
Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00808 · Cited by 288
“Physically, childhood trauma has been associated with increased risk of cardiovascular disease (6), autoimmune disease (7), gastrointestinal symptoms (8), poor dental health (9), obesity, and type 2 diabetes (10).”
BackgroundLabanski, A., Langhorst, J., Engler, H., & Elsenbruch, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104501 · Cited by 200
Metadata
- Authors
- Park, S. H., Videlock, E. J., Shih, W., Presson, A. P., Mayer, E. A., & Chang, L.
- Affiliations
- University of California, Los Angeles (US)
- University of Utah (US)
- Corresponding author
- Chang, L.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2016-04-08
- Volume
- 28
- Issue
- 8
- Pages
- 1252-1260
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- PMC
- PMC4956522
- OpenAlex
- W2317543412
- Cited by
- 156
- References
- 38
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 24 · 2023: 12 · 2022: 17 · 2021: 11 · 2020: 25 · 2019: 14 · 2018: 9 · 2017: 7 · 2016: 1
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- Funders
- NIH/NIDDK (P50 DK064539, P30 DK41301)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- adverse childhood experiences, irritable bowel syndrome, gastrointestinal symptom severity, abdominal pain, early trauma, emotional abuse, household mental illness, childhood abuse
- MeSH terms
- Adult Survivors of Child Adverse Events, Adult, Female, Humans, Life Change Events, Male, Severity of Illness Index, Abdominal Pain, Child of Impaired Parents, Gastrointestinal Tract, Irritable Bowel Syndrome, Young Adult, Symptom Assessment
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