Weaning stress and gastrointestinal barrier development: implications for lifelong gut health in pigs
Open accessAbstract
The gastrointestinal (GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions (e.g., digestion, absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility. Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed.
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In piglets, early weaning stress impairs intestinal barrier function and increases inflammation and oxidative stress.
“In piglets, early weaning stress impairs intestinal barrier function (271) and increases inflammation (272) and oxidative stress (273).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [271]
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- Authors
- Moeser, A. J., Pohl, C. S., & Rajput, M.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Moeser, Adam J.
- Venue
- Animal nutrition
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 3
- Issue
- 4
- Pages
- 313-321
- ISSN
- 2405-6383 (ISSN-L)
- 2405-6545
- PMC
- PMC5941262
- OpenAlex
- W2732972012
- Cited by
- 452
- References
- 95
- Citations by year
- 2026: 54 · 2025: 53 · 2024: 61 · 2023: 63 · 2022: 85 · 2021: 60 · 2020: 38 · 2019: 34 · 2018: 4
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Animal nutrition (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (HD072968)
- USDA National Institute of Food and Agriculture (2017-67015-26673)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- weaning stress, gastrointestinal barrier, pigs, gut health, intestinal epithelium, enteric nervous system, intestinal immunity, disease susceptibility, early life stress, barrier dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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