Cited by 453Animal Nutrition and PhysiologyVeterinary medicine and infectious diseasesGastrointestinal motility and disorders

Weaning stress and gastrointestinal barrier development: implications for lifelong gut health in pigs

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Moeser, Adam J., Pohl, Calvin S., Rajput, Mrigendra·2017·Animal nutrition

Abstract

The gastrointestinal (GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions (e.g., digestion, absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility. Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed.

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Authors
Moeser, A. J., Pohl, C. S., & Rajput, M.
Affiliations
Michigan State University (US)
Corresponding author
Moeser, Adam J.
Venue
Animal nutrition
Publisher
Elsevier BV
Published
2017-12
Volume
3
Issue
4
Pages
313-321
ISSN
  • 2405-6383 (ISSN-L)
  • 2405-6545
OpenAlex
W2732972012
Cited by
452
References
95
Citations by year
2026: 54 · 2025: 53 · 2024: 61 · 2023: 63 · 2022: 85 · 2021: 60 · 2020: 38 · 2019: 34 · 2018: 4
FWCI
2.53
Type
journal article
Language
en
Open access
Locations
  • Animal nutrition (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (HD072968)
  • USDA National Institute of Food and Agriculture (2017-67015-26673)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
weaning stress, gastrointestinal barrier, pigs, gut health, intestinal epithelium, enteric nervous system, intestinal immunity, disease susceptibility, early life stress, barrier dysfunction

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