Cited by 156Gastrointestinal motility and disordersChild Abuse and TraumaPsychosomatic Disorders and Their Treatments

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Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity

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Park, S. H., Videlock, E. J., Shih, W., Presson, A. P., Mayer, E. A., Chang, L.·2016·Neurogastroenterology & Motility

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Abstract

Background: Early adverse life events (EAL s) are associated with irritable bowel syndrome (IBS). Exposure to EAL s as assessed by the Adverse Childhood Experiences (ACE) questionnaire is associated with greater disease prevalence, but ACE has not been studied in gastrointestinal disorders. Study aims were to: (i) Estimate the prevalence of EAL s in the IBS patients using the ACE questionnaire; (ii) Determine correlations between ACE and Early Trauma Inventory Self Report‐Short Form (ETI‐SR) scores to confirm its validity in IBS; and (iii) Correlate ACE scores with IBS symptom severity. Methods: A total of 148 IBS (73% women, mean age = 31 years) and 154 HC s (59% women, mean age = 30 years) completed the ACE and ETI‐SR between June 2010 and April 2015. These surveys measured EAL s before age 18 in the domains of physical, sexual, and emotional abuse, and general trauma. IBS and abdominal pain severity was measured by a 20‐point scale (0 = none, 20 = worst symptoms). Key Results: The ACE score increased the odds of having IBS (odds ratio [OR] = 2.05, 95% confidence interval [CI]: 1.21–3.48, p = 0.008). Household mental illness (p < 0.001), emotional abuse (p = 0.004), and incarcerated household member (p = 0.019) were significant predictors of IBS. Adverse childhood experiences and ETI‐SR scores were strongly correlated (r = 0.59, p < 0.001). ACE, but not ETI‐SR, modestly correlated with IBS severity (r = 0.17, p = 0.036) and abdominal pain (r = 0.20, p = 0.015). Conclusions & Inferences: The ACE questionnaire is a useful instrument to measure EAL s in IBS based on its use in large studies, its ability to measure prevalence across different EAL domains, and its correlation with symptom severity.

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Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(98)00017-8 · Cited by 18,943
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Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
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Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
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Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
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The impact of patient-centered care on outcomes.
Stewart, M., Brown, J. B., DONNER, A. P., McWhinney, I. R., Oates, J., Weston, W. W., & Jordan, J. (2000) · PubMed · Cited by 2,508
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Drossman, D. A., Leserman, J., Nachman, G., Li, Z., Gluck, H., Toomey, T. C., & Mitchell, C. M. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-11-828 · Cited by 898
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Gilbert, L. K., Breiding, M. J., Merrick, M. T., Thompson, W., Ford, D. C., Dhingra, S. S., & Parks, S. E. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.09.006 · Cited by 615
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Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614
Psychometric properties of the Early Trauma Inventory-Self Report
Bremner, J. D., Bolus, R., & Mayer, E. A. (2007) · Journal of Nervous & Mental Disease · doi:10.1097/01.nmd.0000243824.84651.6c · Cited by 550
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Authors: Park, S. H., Videlock, E. J., Shih, W., Presson, A. P., Mayer, E. A., & Chang, L.
Affiliations: University of California, Los Angeles (US)
University of Utah (US)
Corresponding author: Chang, L.
ORCID: Park, S. H.
Videlock, E. J.
Shih, W.
Presson, A. P.
Mayer, E. A.
Chang, L.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2016-04-08
Volume: 28
Issue: 8
Pages: 1252-1260
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/nmo.12826
PMC: PMC4956522
OpenAlex: W2317543412
Cited by: 156
References: 38
Citations by year: 2026: 16 · 2025: 20 · 2024: 24 · 2023: 12 · 2022: 17 · 2021: 11 · 2020: 25 · 2019: 14 · 2018: 9 · 2017: 7 · 2016: 1
FWCI: 11.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
Funders: NIH/NIDDK (P50 DK064539, P30 DK41301)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: adverse childhood experiences, irritable bowel syndrome, gastrointestinal symptom severity, abdominal pain, early trauma, emotional abuse, household mental illness, childhood abuse
MeSH terms: Adult Survivors of Child Adverse Events, Adult, Female, Humans, Life Change Events, Male, Severity of Illness Index, Abdominal Pain, Child of Impaired Parents, Gastrointestinal Tract, Irritable Bowel Syndrome, Young Adult, Symptom Assessment

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Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity

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