Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans
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Aims: In humans, impaired gastric accommodation is associated with early satiety and weight loss. In animals, accommodation involves activation of gastric nitrergic neurones. Our aim was to study involvement of nitric oxide in gastric accommodation and in meal induced satiety in humans. Methods: The effect of N G -monomethyl- l -arginine (l -NMMA) 4 mg/kg/h and 8 mg/kg/h on gastric compliance, on sensitivity to distension, and on gastric accommodation was studied with a barostat in double blind, randomised, placebo controlled studies. The effect of l -NMMA 8 mg/kg/h on meal induced satiety was studied using a drinking test. Results: l -NMMA had no significant effect on fasting compliance and sensitivity. Ingestion of a meal induced a relaxation of 274 (15) ml which was significantly smaller after l -NMMA 4 mg/kg/h (132 (45) ml; p=0.03) or l -NMMA 8 mg/kg/h (82 (72) ml; p=0.03). l -NMMA 8 mg/kg/h significantly decreased the amount of food ingested at maximum satiety from 1058 (67) to 892 (73) kcal (p<0.01). Conclusion: In humans, fasting gastric tone and sensitivity to distension are not influenced by nitric oxide synthase inhibition, but the gastric accommodation reflex involves activation of nitrergic neurones. Inhibition of nitric oxide synthase impairs accommodation and enhances meal induced satiety.
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l-NMMA at 4 mg/kg/h stimulated small intestinal motility and reduced postprandial accommodation in healthy subjects.
“In healthy subjects, this dose stimulated small intestinal motility (38) and reduced postprandial accommodation (45).”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [45]
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- Authors
- Tack, J., Demedts, I., Meulemans, A., Schuurkes, J., & Janssens, J.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Janssen (Belgium) (BE)
- Corresponding author
- Tack, J
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2002-08
- Volume
- 51
- Issue
- 2
- Pages
- 219-224
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1773301
- OpenAlex
- W2000621683
- Cited by
- 210
- References
- 41
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 11 · 2016: 12 · 2015: 6 · 2014: 4 · 2013: 9 · 2012: 7
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- nitric oxide, gastric accommodation, nitric oxide synthase inhibition, L-NMMA, gastric compliance, early satiety, weight loss
- MeSH terms
- Adaptation, Physiological, Adult, Double-Blind Method, Eating, Enzyme Inhibitors, Female, Humans, Male, Nitric Oxide, Satiation, Stomach, Nitric Oxide Synthase, omega-N-Methylarginine
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