Propagation patterns of jejunal motor activity measured by high‐resolution water‐perfused manometry
Open accessAbstract
BACKGROUND: The manometric diagnosis of severe intestinal dysmotility is performed at most institutions using catheters with 2-8 sensors 5-10 cm apart. The recent application of high-resolution manometry catheters with closely spaced sensors to other gut segments has been highly successful. The objective of the present study was to determine the feasibility of a jejunal high-resolution manometry method and to carry out a descriptive analysis of normal jejunal motor function. METHODS: A 36-channel high-resolution water-perfused manometry catheter (MMS-Laborie, Enschede, The Netherlands) was orally placed in the jejunum of 18 healthy subjects (10 men, eight women; 21-38 age range). Intestinal motility was recorded during 5 h, 3 during fasting, and 2 after a 450 kcal solid-liquid meal. Analysis of motility patterns was supported by computerized tools. KEY RESULTS: All healthy subjects except one showed at least one complete migrating motor complex during the 3 h fasting period. Phase III activity lasted 5 ± 1 min and migrated aborally at a velocity of 7 ± 3 cm/min. High-resolution spatial analysis showed that during phase III each individual contraction propagated rapidly (75 ± 37 cm/min) over a 32 ± 10 cm segment of the jejunum. During phase II, most contractile activity corresponded to propagated contractile events which increased in frequency from early to late phase II (0.5 ± 0.9 vs 2.5 ± 1.3 events/10 min, respectively; p < 0.001). After meal ingestion, non-propagated activity increased, whereas propagated events were less frequent than during late phase II. CONCLUSIONS & INFERENCES: Jejunal motility analysis with high-resolution manometry identifies propagated contractile patterns which are not apparent with conventional manometric catheters.
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Advanced techniques, including antroduodenal‐jejunal manometry, wireless motility capsule, gastric ultrasound, and high‐resolution electrogastrography (EGG), may provide additional pathophysiological insight, particularly in complex or mixed‐pattern cases.
“Advanced techniques, including antroduodenal‑jejunal manometry [71–75], wireless motility capsule [76–79], gastric ultrasound [80–82], and high‑resolution electrogastrography (EGG) [83–87] may provide additional pathophysiological insight, particularly in complex or mixed‑pattern cases.”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [72]
The Introduction and Discussion describe high-resolution jejunal manometry as useful for analysing propagation patterns and potentially valuable for diagnosis. The Discussion says its clinical relevance in patients with suspected dysmotility remains to be established; the study does not specifically address complex or mixed-pattern cases. This citation is attached to manometry, not to the other techniques listed in the sentence. (LLM, conf=0.85)
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- Authors
- Alcala‐Gonzalez, L. G., Malagelada, C., Galan, C., Nieto, A., Accarino, A., & Azpiroz, F.
- Affiliations
- Digestive System Research Unit, University Hospital Vall d'Hebron Barcelona Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd) Spain
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Malagelada, Carolina
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2021-08-11
- Volume
- 33
- Issue
- 12
- Pages
- e14240-e14240
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W3189389643
- Cited by
- 13
- References
- 23
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurogastroenterology & Motility (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by-nc-nd)
- Funders
- Societat Catalana de Digestologia
- Ministerio de Ciencia e Innovación (SAF 2016‐76648‐R)
- Instituto de Salud Carlos III (PI17/01794, CM20/00182)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Keywords
- jejunal motility, migrating motor complex, high-resolution manometry, phase III migrating motor complex, postprandial motility, intestinal dysmotility
- MeSH terms
- Adult, Eating, Fasting, Female, Humans, Jejunum, Male, Manometry, Prospective Studies, Water, Myoelectric Complex, Migrating, Young Adult
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