CoChat
Sign Up
Cited by 35Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsGastrointestinal Bleeding Diagnosis and Treatment

Comprehensive characterization of antral and pyloric contractions by high resolution manometry: applied physiology in suspected gastroparesis

Open access
Zheng, Ting, BouSaba, Joelle, Sannaa, Wassel, Eckert, Deborah J., Burton, Duane D., Camilleri, Michael·2022·American Journal of Physiology-Gastrointestinal and Liver Physiology
DOI 10.1152/ajpgi.00119.2022PMC PMC9448275
Open this paper in CoChat — free account

Abstract

Current selection of different treatments for patients with gastroparesis is empiric or based on trial and error, though pyloric distensibility and diameter may predict response to pyloric interventions. High-resolution antropyloroduodenal manometry (HR-ADM) can characterize a variety of postprandial antral contractile and pyloric motility dysfunctions in patients with suspected gastroparesis. HR-ADM shows promise to provide guidance for selection and individualization of treatments such as prokinetic agents or pyloric interventions for patients with gastroparesis based on documented pathophysiology.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1152/ajpgi.00119.2022

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Advanced techniques, including antroduodenal‐jejunal manometry, wireless motility capsule, gastric ultrasound, and high‐resolution electrogastrography (EGG), may provide additional pathophysiological insight, particularly in complex or mixed‐pattern cases.

    “Advanced techniques, including antroduodenal‑jejunal manometry [71–75], wireless motility capsule [76–79], gastric ultrasound [80–82], and high‑resolution electrogastrography (EGG) [83–87] may provide additional pathophysiological insight, particularly in complex or mixed‑pattern cases.”

    From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [74]

    Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

No citation lists for this paper

No citation lists for this paper yet — checked again daily.

References 28 · Cited by 35

Research works printed but not linked: 26

  1. [1]1. Abell TL, Camilleri M, Donohoe K, Hasler WL, Lin HC, Maurer AH, McCallum RW, Nowak T, Nusynowitz ML, Parkman HP, Shreve P, Szarka LA, Snape WJ Jr, Ziessman HA; American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Am J Gastroenterol 103: 753–763, 2008. doi: 10.1111/j.1572-0241.2007.01636.x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  2. [2]2. Vijayvargiya P, Camilleri M, Chedid V, Mandawat A, Erwin PJ, Murad MH. Effects of promotility agents on gastric emptying and symptoms: a systematic review and meta-analysis. Gastroenterology 156: 1650–1660, 2019. doi: 10.1053/j.gastro.2019.01.249. [DOI] [PubMed] [Google Scholar] · DOI
  3. [3]3. Desprez C, Melchior C, Wuestenberghs F, Zalar A, Jacques J, Leroi AM, Gourcerol G. Pyloric distensibility measurement predicts symptomatic response to intrapyloric botulinum toxin injection. Gastrointest Endosc 90: 754–760.e1, 2019. doi: 10.1016/j.gie.2019.04.228. [DOI] [PubMed] [Google Scholar] · DOI
  4. [4]4. Arts J, Holvoet L, Caenepeel P, Bisschops R, Sifrim D, Verbeke K, Janssens J, Tack J. Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis. Aliment Pharmacol Ther 26: 1251–1258, 2007. doi: 10.1111/j.1365-2036.2007.03467.x. [DOI] [PubMed] [Google Scholar] · DOI
  5. [5]5. Friedenberg FK, Palit A, Parkman HP, Hanlon A, Nelson DB. Botulinum toxin A for the treatment of delayed gastric emptying. Am J Gastroenterol 103: 416–423, 2008. doi: 10.1111/j.1572-0241.2007.01676.x. [DOI] [PubMed] [Google Scholar] · DOI
  6. [6]6. Abell TL, Yamada G, McCallum RW, Van Natta ML, Tonascia J, Parkman HP, Koch KL, Sarosiek I, Farrugia G, Grover M, Hasler W, Nguyen L, Snape W, Kuo B, Shulman R, Hamilton FA, Pasricha PJ. Effectiveness of gastric electrical stimulation in gastroparesis: results from a large prospectively collected database of national gastroparesis registries. Neurogastroenterol Motil 31: e13714, 2019. doi: 10.1111/nmo.13714. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  7. [7]7. Ducrotte P, Coffin B, Bonaz B, Fontaine S, Bruley Des Varannes S, Zerbib F, Caiazzo R, Grimaud JC, Mion F, Hadjadj S, Valensi PE, Vuitton L, Charpentier G, Ropert A, Altwegg R, Pouderoux P, Dorval E, Dapoigny M, Duboc H, Benhamou PY, Schmidt A, Donnadieu N, Gourcerol G, Guerci B; ENTERRA Research Group. Gastric electrical stimulation reduces refractory vomiting in a randomized crossover trial. Gastroenterology 158: 506–514.e2, 2020. doi: 10.1053/j.gastro.2019.10.018. [DOI] [PubMed] [Google Scholar] · DOI
  8. [8]8. Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L; American College of Gastroenterology. Clinical guideline: management of gastroparesis. Am J Gastroenterol 108: 18–37, 2013. doi: 10.1038/ajg.2012.373. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  9. [9]9. Aghaie Meybodi M, Qumseya BJ, Shakoor D, Lobner K, Vosoughi K, Ichkhanian Y, Khashab MA. Efficacy and feasibility of G-POEM in management of patients with refractory gastroparesis: a systematic review and meta-analysis. Endosc Int Open 7: E322–E329, 2019. doi: 10.1055/a-0812-1458. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  10. [10]10. Vosoughi K, Ichkhanian Y, Benias P, Miller L, Aadam AA, Triggs JR, Law R, Hasler W, Bowers N, Chaves D, Ponte-Neto AM, Draganov P, Yang D, El Halabi M, Sanaei O, Brewer Gutierrez OI, Bulat RS, Pandolfino J, Khashab M. Gastric per-oral endoscopic myotomy (G-POEM) for refractory gastroparesis: results from an international prospective trial. Gut 71: 25–33, 2022. doi: 10.1136/gutjnl-2020-322756. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  11. [11]11. Zheng T, Camilleri M. Selecting optimal patients with gastroparesis for G-POEM procedure. Gut 71: 659–660, 2022. doi: 10.1136/gutjnl-2021-324631. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  12. [12]12. Martinek J, Hustak R, Mares J, Vackova Z, Spicak J, Kieslichova E, Buncova M, Pohl D, Amin S, Tack J. Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomized, sham-controlled trial. Gut. In press. doi: 10.1136/gutjnl-2022-326904. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  13. [13]13. Vosoughi K, Ichkhanian Y, Jacques J, Aadam AA, Benias PC, Law R, Hasler WL, Canakis A, Ragi O, Triggs J, Bowers N, Brewer Gutierrez OI, Kumbhari V, Kalloo AN, Bulat RS, Pandolfino JE, Khashab MA. Role of endoscopic functional luminal imaging probe in predicting the outcome of gastric peroral endoscopic pyloromyotomy (with video). Gastrointest Endosc 91: 1289–1299, 2020. doi: 10.1016/j.gie.2020.01.044. [DOI] [PubMed] [Google Scholar] · DOI
  14. [14]14. Camilleri M. Relationship of motor mechanisms to gastroparesis symptoms: toward individualized treatment. Am J Physiol Gastrointest Liver Physiol 320: G558–G563, 2021. doi: 10.1152/ajpgi.00006.2021. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  15. [15]15. Conchillo JM, Straathof JWA, Mujagic Z, Brouns JH, Bouvy ND, Keszthelyi D, Masclee AAM. Gastric peroral endoscopic pyloromyotomy for decompensated gastroparesis: comprehensive motility analysis in relation to treatment outcomes. Endosc Int Open 9: E137–E144, 2021. doi: 10.1055/a-1311-0859. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  16. [16]16. Thumshirn M, Bruninga K, Camilleri M. Simplifying the evaluation of postprandial antral motor function in patients with suspected gastroparesis. Am J Gastroenterol 92: 1496–1500, 1997. [PubMed] [Google Scholar]
  17. [17]17. Stanghellini V, Camilleri M, Malagelada JR. Chronic idiopathic intestinal pseudo-obstruction—clinical and intestinal manometric findings. Gut 28: 5–12, 1987. doi: 10.1136/gut.28.1.5. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  18. [18]18. Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology 90: 1919–1925, 1986. doi: 10.1016/0016-5085(86)90262-3. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  19. [19]19. Nelson AD, Camilleri M, Acosta A, Busciglio I, Linker Nord S, Boldingh A, Rhoten D, Ryks M, Burton D. Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers. Neurogastroenterol Motil 28: 1705–1713, 2016. doi: 10.1111/nmo.12870. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  20. [20]20. Camilleri M, Iturrino J, Bharucha AE, Burton D, Shin A, Jeong I-D, Zinsmeister AR. Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants. Neurogastroenterol Motil 24: 1076-e562, 2012. doi: 10.1111/j.1365-2982.2012.01972.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  21. [21]21. Tougas G, Eaker EY, Abell TL, Abrahamsson H, Boivin M, Chen J, Hocking MP, Quigley EM, Koch KL, Tokayer AZ, Stanghellini V, Chen Y, Huizinga JD, Rydén J, Bourgeois I, McCallum RW. Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterology 95: 1456–1462, 2000. doi: 10.1111/j.1572-0241.2000.02076.x. [DOI] [PubMed] [Google Scholar] · DOI
  22. [22]22. Camilleri M, Malagelada JR, Stanghellini V, Zinsmeister AR, Kao PC, Li CH. Dose-related effects of synthetic human β-endorphin and naloxone on fed gastrointestinal motility. Am J Physiol Gastrointest Liver Physiol 251: G147–G154, 1986. doi: 10.1152/ajpgi.1986.251.1.G147. [DOI] [PubMed] [Google Scholar] · DOI
  23. [23]23. Camilleri M, Brown ML, Malagelada JR. Relationship between impaired gastric-emptying and abnormal gastrointestinal motility. Gastroenterology 91: 94–99, 1986. doi: 10.1016/0016-5085(86)90444-0. [DOI] [PubMed] [Google Scholar] · DOI
  24. [24]24. Camilleri M, Malagelada JR, Brown ML, Becker G, Zinsmeister AR. Relation between antral motility and gastric-emptying of solids and liquids in humans. Am J Physiol Gastrointest Liver Physiol 249: G580–G585, 1985. doi: 10.1152/ajpgi.1985.249.5.G580. [DOI] [PubMed] [Google Scholar] · DOI
  25. [25]25. Camilleri M, Malagelada JR, Stanghellini V, Fealey RD, Sheps SG. Gastrointestinal motility disturbances in patients with orthostatic hypotension. Gastroenterology 88: 1852–1859, 1985. doi: 10.1016/0016-5085(85)90010-1. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  26. [28]28. Zheng T, Vosoughi K, Busciglio I, Tebay L, Burton D, Camilleri M. Fasting pyloric diameter and distensibility by functional endoluminal imaging probe in unsedated healthy volunteers. Neurogastroenterol Motil e14386, 2022. doi: 10.1111/nmo.14386. [DOI] [PMC free article] [PubMed] [Google Scholar] Articles from American Journal of Physiology - Gastrointestinal and Liver Physiology are provided here courtesy of American Physiological Society · DOI

Authors
Zheng, T., BouSaba, J., Sannaa, W., Eckert, D. J., Burton, D. D., & Camilleri, M.
Affiliations
Mayo Clinic (US)
Corresponding author
Camilleri, Michael
ORCID
Venue
American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher
American Physiological Society
Published
2022-09-01
Volume
323
Issue
3
Pages
G255-G264
ISSN
  • 0193-1857 (ISSN-L)
  • 1522-1547
DOI
10.1152/ajpgi.00119.2022
PMC
PMC9448275
OpenAlex
W4285077248
Cited by
35
References
28
Citations by year
2026: 11 · 2025: 9 · 2024: 9 · 2023: 5 · 2022: 1
FWCI
5.25
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK122280, R01-DK125680)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
Keywords
gastroparesis, antral contractions, postprandial motility, prokinetic agents, treatment selection
MeSH terms
Duodenum, Esophageal Achalasia, Gastric Emptying, Gastrointestinal Motility, Humans, Manometry, Pyloric Antrum, Pylorus, Gastroparesis, Esophageal Sphincter, Lower

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review