The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Heavy metal ATPase 3 (HMA3) confers cadmium hypertolerance on the cadmium/zinc hyperaccumulator Sedum plumbizincicola
Open accessAbstract
Summary: Cadmium (Cd) is highly toxic to most organisms, but some rare plant species can hyperaccumulate Cd in aboveground tissues without suffering from toxicity. The mechanism underlying Cd detoxification by hyperaccumulators is interesting but unclear. Here, the heavy metal ATPase 3 (SpHMA3) gene responsible for Cd detoxification was isolated from the Cd/zinc (Zn) hyperaccumulator Sedum plumbizincicola. RNA interference (RNAi)‐mediated silencing and overexpression of SpHMA3 were induced to investigate its physiological functions in S. plumbizincicola and a nonhyperaccumulating ecotype of Sedum alfredii. Heterologous expression of Sp HMA 3 in Saccharomyces cerevisiae showed Cd‐specific transport activity. Sp HMA 3 was highly expressed in the shoots and the protein was localized to the tonoplast. The Sp HMA 3‐RNA i lines were hypersensitive to Cd but not to Zn, with the growth of shoots and young leaves being severely inhibited by Cd. Overexpressing Sp HMA 3 in the nonhyperaccumulating ecotype of S. alfredii greatly increased its tolerance to and accumulation of Cd, but not Zn. These results indicate that elevated expression of the tonoplast‐localized SpHMA3 in the shoots plays an essential role in Cd detoxification, which contributes to the maintenance of the normal growth of young leaves of S. plumbizincicola in Cd‐contaminated soils.
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Metadata
- Authors
- Liu, H., Zhao, H., Wu, L., Liu, A., Zhao, F., & Xu, W.
- Venue
- New Phytologist
- Publisher
- Wiley
- Published
- 2017-06-02
- Volume
- 215
- Issue
- 2
- Pages
- 687-698
- ISSN
- 0028-646X (ISSN-L)
- 1469-8137
- OpenAlex
- W2621283071
- Cited by
- 282
- References
- 45
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, H., Zhao, H., Wu, L., Liu, A., Zhao, F., & Xu, W. (2017). Heavy metal ATPase 3 (HMA3) confers cadmium hypertolerance on the cadmium/zinc hyperaccumulator Sedum plumbizincicola. New Phytologist. https://doi.org/10.1111/nph.14622
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