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Cited by 203Garlic and Onion StudiesLipoproteins and Cardiovascular HealthNatural Products and Biological Research

The DOI matches its Crossref record; 85 of the 89 references it cites were found in a registry or an index.

Effect of garlic on serum lipids: an updated meta-analysis

Open access
Ried, Karin, Toben, Catherine, Fakler, Peter·2013·Nutrition Reviews
DOI 10.1111/nure.12012
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Abstract

Background: Epidemiologic studies suggest that garlic may have beneficial effects on risk factors associated with cardiovascular disease (CVD).However, these findings are not unambiguously supported by randomized placebo-controlled clinical trials.Objective: We sought to investigate the effects of a chemically well-characterized garlic preparation on biomarkers for inflammation, endothelial function, and lipid metabolism in subjects with risk factors for CVD.Design: This was a double-blind, randomized, placebo-controlled trial in 90 overweight [body mass index (in kg/m 2 ) 24.5] subjects aged 40 -75 y who smoked 10 cigarettes/d.The subjects were randomly assigned to 3 parallel treatment groups: garlic powder (2.1 g/d), atorvastatin (40 mg/d), or placebo.Duplicate measurements were performed at baseline and after 1 and 3 mo of treatment.Treatments were compared with analysis of covariance with baseline as the covariate, and differences between the treatments were reported as mean percentage difference and corresponding 97.5% CI.Results: None of the variables showed significant differences between the garlic-treated and the placebo groups.In contrast, compared with the placebo group, atorvastatin treatment resulted in significantly lower plasma concentrations of C-reactive protein (20.2%; 1.7%, 35.3%), total cholesterol (37.2%; 33.1%, 41.1%), LDL cholesterol (52.7%; 47.9%, 57.1%), triacylglycerols (31.9%; 20.8%, 41.5%), and tumor necrosis factor ␣ (TNF-␣; 41.9%; 19.0%, 58.3%) and increased the ratio of ex vivo whole blood lipopolysaccharidestimulated to nonstimulated TNF-␣ concentrations (109.7%;37.9%, 218.9%). Conclusion:We conclude that a chemically well-characterized garlic preparation has no significant effect on inflammatory biomarkers, endothelial function, or lipid profile in normolipidemic subjects with risk factors for CVD.

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4 of the 89 references couldn’t be matched to a known paper.

Research works printed but not linked: 15

  1. AIHW Australian GP Statistics and Classification Centre, 2010, 2010, SAND abstract No. 151 from the BEACH program: lipid medication use and cardiovascular risk in patients seen in general practice
  2. AIHW Australian GP Statistics and Classification Centre, 2008, 2010, SAND abstract No. 111 from the BEACH program: adverse drug events in general practice patients
  3. Han, 2011, Antihypertensive activities of processed garlic on spontaneously hypertensive rats and hypertensive humans, Bot Stud., 52, 277
  4. 2011, Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0
  5. The Cochrane Collaboration Review Manager (RevMan). Version 5.1.6 2011
  6. Barrie, 1987, Effects of garlic oil on platelet aggregation, serum lipids and blood pressure in humans, J Orthomolecular Med., 2, 15
  7. DeA Santos, 1993, Effect of garlic powder tablets on blood lipids and blood pressure: a six-month placebo-controlled, double-blind study, Br J Clin Res., 4, 37
  8. Rahmani, 1999, Effect of dried garlic supplementation on blood lipids in mild and moderate hypercholesterolemic patients, Arch Iran Med., 2, 19
  9. Kandziora, 1988, Blutdruck- und lipidsenkende Wirkung eines Knoblauch-Präparates in Kombination mit einem Diuretikum (Study 1) [in German], Aerztliche Forschung., 35, 3
  10. Mansell, 1996, The effect of dried garlic powder tablets on serum lipids in non-insulin dependent diabetic patients, Eur J Clin Res., 8, 25
  11. Czerny, 1996, Klinische Untersuchungen mit einem Knoblauch-Lezithin-Präparat [in German], J Arztezeitschr Naturheilverf., 37, 126
  12. Lutomski, 1984, Klinische Untersuchungen zur therapeutischen Wirksamkeit von Ilja Rogoff Knoblauchpillen mit Rutin [in German], Z Phytother., 5, 938
  13. Schmidt, 1991, The lipid lowering effects of garlic powder tablets. A comparative study between a garlic powder preparation and bezafibrate [in German], Med Welt., 42, 6
  14. DeA Santos, 1995, Effects of garlic powder and garlic oil preparations on blood lipids, blood pressure and well-being, Br J Clin Res., 6, 91
  15. Jung, 1991, Influence of garlic on the effect of fat intake on plasma lipids and skin capillary circulation [in German], Med Welt., 42, 16

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Metadata

Authors
Ried, K., Toben, C., & Fakler, P.
Affiliations
  • National Institute of Integrative Medicine (AU)
  • The University of Adelaide (AU)
ORCID
Venue
Nutrition Reviews
Publisher
Oxford University Press (OUP)
Published
2013-03-07
Volume
71
Issue
5
Pages
282-299
ISSN
0029-6643 (ISSN-L)
DOI
10.1111/nure.12012
OpenAlex
W2136157827
Cited by
203
References
89
Citations by year
2026: 8 · 2025: 15 · 2024: 12 · 2023: 16 · 2022: 17 · 2021: 14 · 2020: 16 · 2019: 14 · 2018: 18 · 2017: 19 · 2016: 18 · 2015: 21 · 2014: 14
FWCI
1.89
Type
journal article
Language
en
Open access
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Phaidra (Universität Wien) (submittedVersion, cc-by-nc-nd)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders
  • Primary Health Care Research, Evaluation and Development
  • Australian Government
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
Keywords
garlic, serum lipids, hypercholesterolemia, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, cholesterol-lowering drugs, coronary heart disease risk, dietary intervention
MeSH terms
Anticholesteremic Agents, Cholesterol, Garlic, Humans, Hypercholesterolemia, Phytotherapy, Plant Extracts, Treatment Outcome

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