The DOI matches its Crossref record; 188 of the 188 references it cites were found in a registry or an index.
What is metabolic syndrome, and why are children getting it?
Open accessAbstract
Metabolic syndrome comprises a cluster of cardiovascular risk factors (hypertension, altered glucose metabolism, dyslipidemia, and abdominal obesity) that occur in obese children. However, metabolic syndrome can also occur in lean individuals, suggesting that obesity is a marker for the syndrome, not a cause. Metabolic syndrome is difficult to define, due to its nonuniform classification and reliance on hard cutoffs in the evaluation of disorders with non‐Gaussian distributions. Defining the syndrome is even more difficult in children, owing to racial and pubertal differences and lack of cardiovascular events. Lipid partitioning among specific fat depots is associated with insulin resistance, which can lead to mitochondrial overload and dysfunctional subcellular energy use and drive the various elements of metabolic syndrome. Multiple environmental factors, in particular a typical Western diet, drive mitochondrial overload, while other changes in Western society, such as stress and sleep deprivation, increase insulin resistance and the propensity for food intake. These culminate in an adverse biochemical phenotype, including development of altered glucose metabolism and early atherogenesis during childhood and early adulthood.
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Cites
1 retracted
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Cited by
Collins, K. H., Herzog, W., MacDonald, G. Z., Reimer, R. A., Rios, J. L., Smith, I. C., Zernicke, R. F., & Hart, D. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00112 · Cited by 308
Rinaldi, A. E. M., Gabriel, G. F. C. P., Moreto, F., Corrente, J. E., McLellan, K. C. P., & Burini, R. C. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0178-9 · Cited by 46
Wang, J., Perona, J. S., Schmidt-RioValle, J., Chen, Y., Jing, J., & González-Jiménez, E. (2019) · Nutrients · doi:10.3390/nu11071568 · Cited by 33
Fernández-Aparicio, Á., Schmidt-RioValle, J., Perona, J. S., Correa-Rodríguez, M., Castellano, J. M., & González-Jiménez, E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091294 · Cited by 25
Metadata
- Authors
- Weiss, R., Bremer, A. A., & Lustig, R. H.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2013-01-28
- Volume
- 1281
- Issue
- 1
- Pages
- 123-140
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1576436451
- Cited by
- 307
- References
- 188
- FWCI
- 20.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Weiss, R., Bremer, A. A., & Lustig, R. H. (2013). What is metabolic syndrome, and why are children getting it? Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.12030
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
