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Cited by 616

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival

Open access
Kuo, Wei‐Ting, Odenwald, Matthew A., Turner, Jerrold R., Zuo, Li·2022·Annals of the New York Academy of Sciences
DOI 10.1111/nyas.14798
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Abstract

Epithelial cells are the first line of mucosal defense. In the intestine, a single layer of epithelial cells must establish a selectively permeable barrier that supports nutrient absorption and waste secretion while preventing the leakage of potentially harmful luminal materials. Key to this is the tight junction, which seals the paracellular space and prevents unrestricted leakage. The tight junction is a protein complex established by interactions between members of the claudin, zonula occludens, and tight junction‐associated MARVEL protein (TAMP) families. Claudins form the characteristic tight junction strands seen by freeze‐fracture microscopy and create paracellular channels, but the functions of ZO‐1 and occludin, founding members of the zonula occludens and TAMP families, respectively, are less well defined. Recent studies have revealed that these proteins have essential noncanonical (nonbarrier) functions that allow them to regulate epithelial apoptosis and proliferation, facilitate viral entry, and organize specialized epithelial structures. Surprisingly, neither is required for intestinal barrier function or overall health in the absence of exogenous stressors. Here, we provide a brief overview of ZO‐1 and occludin canonical (barrier‐related) functions, and a more detailed examination of their noncanonical functions.

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Metadata

Authors
Kuo, W., Odenwald, M. A., Turner, J. R., & Zuo, L.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2022-05-17
Volume
1514
Issue
1
Pages
21-33
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/nyas.14798
OpenAlex
W4280529994
Cited by
616
References
110
FWCI
30.39
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival. https://app.cochat.ai/papers/10.1111/nyas.14798
The paper
Kuo, W., Odenwald, M. A., Turner, J. R., & Zuo, L. (2022). Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival. Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.14798

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.