Diabetes, physical activity participation and exercise capacity in patients with schizophrenia
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Aim: The aim of this study was to determine if in schizophrenia patients the presence of diabetes is associated with lower physical activity participation and lower exercise capacity compared to patients with pre‐diabetes and to patients without (pre‐) diabetes. Methods: Schizophrenia patients without (pre‐)diabetes (n = 86) were compared with pre‐diabetic (n = 10) and diabetic patients (n = 10). Patients were assessed on physical activity participation using the Baecke physical activity questionnaire and on exercise capacity using a 6‐min walk test (6MWT). Results: The three groups were similar in age, sex, mean antipsychotic medication dose, negative and depressive symptoms and smoking behavior. Distance achieved on the 6MWT, however, was approximately 15% shorter (P < 0.05) in patients withdiabetes than in patients without (pre‐)diabetes (500.3 ± 76.9 m vs 590.7 ± 101.8 m). Patients with diabetes were also significantly less physically active (P < 0.05). No differences between diabetic and pre‐diabetic patients were found. Pre‐diabetic patients had a higher body mass index (BMI) than non‐diabetic patients (30.0 ± 7.3 vs 24.3 ± 4.3, P < 0.05). An interaction effect with BMI for differences in Baecke (F = 29.9, P < 0.001) and 6MWT (F = 13.0, P < 0.001) scores was seen between diabetic and non‐diabetic patients on univariate ANCOVA. Conclusion: The additive burden of diabetes might place patients with schizophrenia at an even greater risk for functional limitations in daily life.
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Other diagnostic-independent factors likely influence T2DM frequency, including hyperglycaemia following psychotropic medication use and long-term exposure to unhealthy lifestyle behaviors, as well as potential genetic factors linking psychiatric and medical risk.
“Thus, other diagnosticindependent factors likely influence T2DM frequency, including hyperglycaemia following psychotropic medication use 26 and long-term exposure to unhealthy lifestyle behaviors 27,28 , as well as potential genetic factors linking psychiatric and medical risk 29 .”
From Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis (2016) · cites this paper as [28]
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- [2]2. De Hert M, Detraux J, Vancampfort D et al . Severe mental illness and diabetes type 2. Psychiatrie Grundl. Perspekt. 2012; 3 : 159-164.
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- Authors
- Vancampfort, D., De Hert, M., Sweers, K., De Herdt, A., Detraux, J., & Probst, M.
- Affiliations
- KU Leuven (BE)
- Campus Kortenberg UPC KU Leuven Kortenberg
- Corresponding author
- Vancampfort, Davy
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2013-08-13
- Volume
- 67
- Issue
- 6
- Pages
- 451-456
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1874122342
- Cited by
- 34
- References
- 39
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 6 · 2014: 4
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- H. Lundbeck A/S
- Cilag
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- schizophrenia, diabetes mellitus, physical activity, exercise capacity, prediabetes, 6-minute walk test, body mass index, functional limitations, comorbidities
- MeSH terms
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Motor Activity, Psychiatric Status Rating Scales, Surveys and Questionnaires, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Walking, Exercise Tolerance, Diagnostic and Statistical Manual of Mental Disorders, Diabetes Complications, Young Adult
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