Puberty as an accelerator for diabetes complications
Abstract
Much is written about how difficult it is to deal with diabetes during adolescence, and rightly so. Less is understood as to how puberty may be an accelerator of vascular complications. With the increase in childhood diabetes, complication risks need to be revisited in relation to puberty and the secular increase in adiposity. Recent data suggest greater risk for severe vascular complications in those with diabetes during puberty, compared with young people who develop diabetes after puberty. It is also widely recognized that higher hemoglobin A1c (HbA1c) results are often seen during the pubertal period. This article will review complication outcomes in relation to puberty and examine mechanisms by which puberty may modify risk above glycemic exposure, and possible gender disparities in the risk of complications in the adolescent period.
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Puberty seems to speed up complication development in type 1 diabetes.
“Type 1 diabetes during puberty also appears to accelerate the development of complications.117”
From Type 1 diabetes (2018) · cites this paper as [117]
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- Authors
- Cho, Y. H., Craig, M. E., & Donaghue, K. C.
- Affiliations
- The University of Sydney (AU)
- Venue
- Pediatric Diabetes
- Publisher
- Wiley
- Published
- 2014-01-20
- Volume
- 15
- Issue
- 1
- Pages
- 18-26
- ISSN
- 1399-543X (ISSN-L)
- OpenAlex
- W1710295512
- Cited by
- 145
- References
- 71
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 10 · 2023: 11 · 2022: 10 · 2021: 20 · 2020: 13 · 2019: 14 · 2018: 17 · 2017: 11 · 2016: 15 · 2015: 6 · 2014: 5
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- puberty, diabetes complications, vascular complications, adolescent diabetes, pediatric diabetes, adiposity, HbA1c, glycemic control, gender differences, complication risk
- MeSH terms
- Adolescent, Albuminuria, Child, Child, Preschool, Diabetes Mellitus, Type 1, Diabetic Retinopathy, Female, Glycated Hemoglobin, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Male, Obesity, Polycystic Ovary Syndrome, Puberty, Sexual Maturation, Age of Onset, Human Growth Hormone, Diabetes Complications, Adiposity
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