Photodynamic Therapy for Cancer: What's Past is Prologue
Open accessAbstract
Thomas J Dougherty from Roswell Park Cancer Center played a major role in the progress of photodynamic therapy (PDT) from a laboratory science into a real‐world clinical therapy to treat patients with cancer. Nevertheless over the succeeding 45 years, it is fair to say that the overall progress of clinical PDT for cancer has been somewhat disappointing. The goal of this perspective article is to summarize some of the clinical trials run by various companies using photosensitizers with different structures that have been conducted for different types of cancer. While some have been successful, others have failed, and several are now ongoing. I will attempt to touch on some factors, which have influenced this checkered history and look forward to the future of clinical PDT for cancer.
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Chlorin has absorption at 662 nm and has been shown to be less painful to patients than MAL and ALA treatments.
“A further photosensitizing drug, chlorin, comprising of chlorin e6, chlorin p6, and purpurin 5, has been approved for use in Russia and Republic of Korea with absorption at 662 nm and has been shown to be less painful to patients than MAL and ALA treatments.66,67,114”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [114]
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- Authors
- Hamblin, M. R.
- Affiliations
- Harvard University (US)
- Corresponding author
- Hamblin, Michael R.
- ORCID
- Hamblin, Michael R.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2020-01-07
- Volume
- 96
- Issue
- 3
- Pages
- 506-516
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- PMC
- PMC7282978
- OpenAlex
- W2996537976
- Cited by
- 310
- References
- 82
- Citations by year
- 2026: 30 · 2025: 49 · 2024: 56 · 2023: 59 · 2022: 59 · 2021: 42 · 2020: 14 · 2014: 1
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01AI050875, R21AI121700)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- photodynamic therapy, cancer, photosensitizers, clinical trials, history of photodynamic therapy, clinical translation, treatment failure
- MeSH terms
- Humans, Neoplasms, Photochemotherapy, Photosensitizing Agents
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