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Cited by 109Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsOral and gingival health research

Gingival crevicular fluid and its immune mediators in the proteomic era

Bostanci, Nagihan, Belibasakis, Georgios N.·2018·Periodontology 2000
DOI 10.1111/prd.12154
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Abstract

The discovery of biomarkers for periodontal disease requires an in‐depth understanding of the molecular basis of the initiation and progression of the disease. The gingival crevicular fluid is a biological medium suitable for identifying and measuring such biomarkers because it can be easily and noninvasively sampled from the immediate vicinity of the affected tissues. An ever‐expanding pool of gingival crevicular fluid proteins associated with periodontal health or disease has been catalogued over the years, particularly with the recent implementation of proteomic technologies. ‘Proteomics’ refers to the large‐scale study of entire arrays of proteins expressed by a genome and present in a cell, tissue, biological fluid or organism. Hence, such technologies provide a broad qualitative and quantitative insight of the proteins present in gingival crevicular fluid. Pertinent studies have amassed on the information gathered to date on protein signatures in periodontal health and disease, and have confirmed the nature of the immunological host response. This review discusses the application of proteomic technologies in characterizing the molecular networks present in gingival crevicular fluid, their potential for discovery of biomarkers that are meaningful for clinical practice, and the associated technical challenges.

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Crossref · 10.1111/prd.12154

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89 of 89 references verified0 citation errors · 0 not checkable

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  • The absorption technique through paper strips is the easiest and most accurate method for obtaining gingival crevicular fluid exudate.

    “GCF collection methods include intracrevicular lavage technique, microcapillary technique and absorption technique through the use of paper strips being the easiest and most accurate method for obtaining such exudate [90].”

    From Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review (2023) · cites this paper as [90]

  • Proteomic applications have been applied to understand changes in the proteome that diverge states of periodontal health from disease and to further characterize various periodontal disease states, including gingivitis, mild, moderate, chronic, and aggressive periodontitis.

    “Proteomic applications have been applied to understand changes in the proteome that diverge states of periodontal health from disease and to further characterize various periodontal disease states, including gingivitis, mild, moderate, chronic, and aggressive periodontitis.70, 101, 102, 103, 104”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [102]

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Authors
Bostanci, N., & Belibasakis, G. N.
ORCID
Belibasakis, Georgios N.
Venue
Periodontology 2000
Publisher
Wiley
Published
2017-11-30
Volume
76
Issue
1
Pages
68-84
ISSN
  • 0906-6713 (ISSN-L)
  • 1600-0757
DOI
10.1111/prd.12154
OpenAlex
W2773076305
Cited by
109
References
89
Citations by year
2026: 9 · 2025: 15 · 2024: 17 · 2023: 10 · 2022: 9 · 2021: 20 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 2
FWCI
1.11
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Periodontology 2000 (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
Keywords
gingival crevicular fluid, periodontal disease, biomarkers, proteomics, host immune response, periodontitis, non-invasive diagnosis
MeSH terms
Diagnosis, Oral, Gingival Crevicular Fluid, Humans, Immunologic Factors, Inflammation, Periodontal Pocket, Biomarkers, Cytokines, Disease Progression, Proteomics, High-Throughput Screening Assays

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