The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Presentation of Phagocytosed Antigens by MHC Class I and II
Open accessAbstract
Phagocytosis provides innate immune cells with a mechanism to take up and destroy pathogenic bacteria, apoptotic cells and other large particles. In some cases, however, peptide antigens from these particles are preserved for presentation in association with major histocompatibility complex (MHC) class I or class II molecules in order to stimulate antigen‐specific T cells. Processing and presentation of antigens from phagosomes presents a number of distinct challenges relative to antigens internalized by other means; while bacterial antigens were among the first discovered to be presented to T cells, analyses of the cellular mechanisms by which peptides from phagocytosed antigens assemble with MHC molecules and by which these complexes are then expressed at the plasma membrane have lagged behind those of conventional model soluble antigens. In this review, we cover recent advances in our understanding of these processes, including the unique cross‐presentation of phagocytosed antigens by MHC class I molecules, and in their control by signaling modalities in phagocytic cells.
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1 retracted
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Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
Junker, F., Gordon, J., & Qureshi, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01393 · Cited by 219
Antigen processing and presentation
(2019) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.07.005 · Cited by 194
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Emergence and significance of carbohydrate-specific antibodies
Kappler, K., & Hennet, T. (2020) · Genes & Immunity · doi:10.1038/s41435-020-0105-9 · Cited by 118
Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture
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Metadata
- Authors
- Mantegazza, A. R., Magalhaes, J. G., Amigorena, S., & Marks, M. S.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2012-11-29
- Volume
- 14
- Issue
- 2
- Pages
- 135-152
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1548452743
- Cited by
- 259
- References
- 215
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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