The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Clinical application of growth factors and cytokines in wound healing
Open accessAbstract
Wound healing is a complex and dynamic biological process that involves the coordinated efforts of multiple cell types and is executed and regulated by numerous growth factors and cytokines. There has been a drive in the past two decades to study the therapeutic effects of various growth factors in the clinical management of nonhealing wounds (e.g., pressure ulcers, chronic venous ulcers, diabetic foot ulcers). For this review, we conducted an online search of M edline/PubMed and critically analyzed the literature regarding the role of growth factors and cytokines in the management of these wounds. We focused on currently approved therapies, emerging therapies, and future research possibilities. In this review, we discuss four growth factors and cytokines currently being used on and off label for the healing of wounds. These include granulocyte‐macrophage colony‐stimulating factor, platelet‐derived growth factor, vascular endothelial growth factor, and basic fibroblast growth factor. While the clinical results of using growth factors and cytokines are encouraging, many studies involved a small sample size and are disparate in measured endpoints. Therefore, further research is required to provide definitive evidence of efficacy.
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Citations
Cites
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
Brown, L. F., Yeo, K. T., Berse, B., Yeo, T. K., Senger, D. R., Dvorak, H. F., & van de Water, L. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.5.1375 · Cited by 878
Interactions of cytokines, growth factors, and proteases in acute and chronic wounds
Mast, B. A., & Schultz, G. S. (1996) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1996.40404.x · Cited by 598
Smiell, J. M., Wieman, T. J., Steed, D. L., Perry, B. H., Sampson, A. R., & Schwab, B. H. (1999) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1999.00335.x · Cited by 454
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Cited by
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Self-citationTherapeutic strategies for enhancing angiogenesis in wound healing
Veith, A. P., Henderson, K., Spencer, A., Sligar, A. D., & Baker, A. B. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.010 · Cited by 1,021
The Role of MSC in Wound Healing, Scarring and Regeneration
Guillamat-Prats, R. (2021) · Cells · doi:10.3390/cells10071729 · Cited by 393
Pang, Y., Wang, H., Yao, Y., Chen, D., Yang, R., Wang, Z., Yang, J., Li, Y., & Liu, W. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202303095 · Cited by 76
RETRACTED: Skin boosters: Definitions and varied classifications
Yi, K., Winayanuwattikun, W., Kim, S., Wan, J., Vachatimanont, V., Putri, A. I., Hidajat, I. J., Yogya, Y., & Pamela, R. (2024) · Skin Research and Technology · doi:10.1111/srt.13627 · Cited by 74
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Metadata
- Authors
- Barrientos, S., Brem, H., Stojadinovic, O., & Tomic‐Canic, M.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2014-09
- Volume
- 22
- Issue
- 5
- Pages
- 569-578
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W1586551928
- Cited by
- 635
- References
- 5
- FWCI
- 28.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Barrientos, S., Brem, H., Stojadinovic, O., & Tomic‐Canic, M. (2014). Clinical application of growth factors and cytokines in wound healing. Wound Repair and Regeneration. https://doi.org/10.1111/wrr.12205
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
