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Cited by 74Facial Rejuvenation and Surgery TechniquesSkin Protection and AgingDermatologic Treatments and Research

RETRACTED: Skin boosters: Definitions and varied classifications

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Yi, Kyu‐Ho, Winayanuwattikun, Waranaree, Kim, Sung‐Yeon, Wan, Jovian, Vachatimanont, Vanravi, Putri, Ardhiah Iswanda, Hidajat, Inneke Jane, Yogya, Yuri +1 more·2024·Skin Research and Technology
DOI 10.1111/srt.13627PMC PMC10938033
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Abstract

Background: The concept of “skin boosters” has evolved, marking a shift from traditional uses of hyaluronic acid (HA) fillers primarily for augmenting skin volume to a more diverse application aimed at improving dermal conditions. Restylane Vital and other HA fillers have been repurposed to combat skin aging and wrinkles by delivering HA directly to the dermis. Objectives: This review aims to define the term “skin booster” and to discuss the various components that constitute skin boosters. It seeks to provide a comprehensive overview of the different ingredients used in skin boosters, their roles, and their impact on enhancing dermal conditions. Methods: A comprehensive review was conducted, focusing on representative skin booster ingredients. The approach involved analyzing the different elements used in skin boosters and their specific roles in enhancing dermal improvement. Results: The findings indicate that skin boosters, encompassing a range of ingredients, are effective in improving the condition of the skin's dermis. The review identifies key ingredients in skin boosters and their specific benefits, including hydration, elasticity improvement, and wrinkle reduction. Conclusions: Skin boosters represent a significant development in dermatological treatments, offering diverse benefits beyond traditional HA fillers. This review provides valuable insights into the constituents of skin boosters and their effectiveness, aiding readers in making informed decisions about these treatments. The potential of skin boosters in dermatological practice is considerable, warranting further research and application.

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  • Despite limited sample size in some reported studies, PN treatment has yielded improvements in facial fine lines, overall skin texture, wrinkles, and tone.

    “Despite the limited sample size in some reported studies, PN treatment has also yielded improvements in facial fine lines, overall skin texture, wrinkles, and tone [15,153,171,172].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [15]

    In the ‘Deoxyribonucleic fragments’ section (page unavailable), the review reports improved tone and wrinkles in a five-patient PN study, and improved roughness in a 27-person PN trial, supporting the small-study qualification and the skin-texture claim. It does not specifically report an improvement in facial fine lines from PN; the passage mentioning fine lines concerns platelet-rich plasma instead. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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  1. [1]Landau M, Fagien S. Science of hyaluronic acid beyond filling: fibroblasts and their response to the extracellular matrix. Plast Reconstr Surg. 2015; 136(suppl 5): 188S‐ 195S. doi: 10.1097/PRS.0000000000001823 26441098 · DOI
  2. [3]Wang F, Garza LA, Kang S, et al. In vivo stimulation of de novo collagen production caused by cross‐linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol. 2007; 143(2): 155‐ 163. doi: 10.1001/archderm.143.2.155 17309996 · DOI
  3. [4]Yi KH, Lee JJ, Hur HW, Bae H, Kim HJ. Hyaluronic acid filler injection for deep nasolabial folds: a novel intraoral approach. Clin Anat. 2022; 35(6): 820‐ 823. Epub 20220614. doi: 10.1002/ca.23919 35665540 · DOI
  4. [5]Chen F, Guo X, Wu Y. Skin antiaging effects of a multiple mechanisms hyaluronan complex. Skin Res Technol. 2023; 29(6): e13350. doi: 10.1111/srt.13350 37357659 PMC10225814 · DOI
  5. [6]Hertz‐Kleptow D, Hanschmann A, Hofmann M, Reuther T, Kerscher M. Facial skin revitalization with CPM(®)‐HA20G: an effective and safe early intervention treatment. Clin Cosmet Investig Dermatol. 2019; 12: 563‐ 572. Epub 20190813. doi: 10.2147/ccid.S209256 PMC6698156 31496779 · DOI
  6. [7]Kleine‐Börger L, Hofmann M, Kerscher M. Microinjections with hyaluronic acid in combination with glycerol: how do they influence biophysical viscoelastic skin properties? Skin Res Technol. 2022; 28(4): 633‐ 642. doi: 10.1111/srt.13167 35643988 PMC9907673 · DOI
  7. [8]Schwartz J, Friedman AJ. Exogenous factors in skin barrier repair. J Drugs Dermatol. 2016; 15(11): 1289‐ 1294. PubMed PMID: 28095538 28095538
  8. [9]Fluhr J, Bornkessel A, Berardesca E. Glycerol—just a moisturizer? Biological and biophysical effects. Dry Skin and Moisturizers (pp. 227‐ 243). CRC Press; 2005.
  9. [10]Heidemann W, Jeschkeit S, Ruffieux K, et al. Degradation of poly(D,L)lactide implants with or without addition of calciumphosphates in vivo. Biomaterials. 2001; 22(17): 2371‐ 2381. doi: 10.1016/s0142-9612(00)00424-5 11511034 · DOI
  10. [11]Belmontesi M, De Angelis F, Di Gregorio C, et al. Injectable non‐animal stabilized hyaluronic acid as a skin quality booster: an expert panel consensus. J Drugs Dermatol. 2018; 17(1): 83‐ 88. PubMed PMID: 29320592 29320592
  11. [12]Iqbal N. Recent concepts in biodegradable polymers for tissue engineering paradigms: a critical review. Int Mater Rev. 2018; 64: 91‐ 126. doi: 10.1080/09506608.2018.1460943 · DOI
  12. [13]Sit RW, Chung V, Reeves KD, et al. Hypertonic dextrose injections (prolotherapy) in the treatment of symptomatic knee osteoarthritis: a systematic review and meta‐analysis. Sci Rep. 2016; 6: 25247. Epub 20160505. doi: 10.1038/srep25247 27146849 PMC4857084 · DOI
  13. [14]de Luca Brunori I, Battini L, Filippeschi M, Romani L, Tarani A, Urbano M. [Topical therapy with placental polydeoxyribonucleotide in cervical ectopy and ectropion]. Ann Ostet Ginecol Med Perinat. 1989; 110(1): 35‐ 41. PubMed PMID: 2757327 2757327
  14. [15]Perino A, Genova G, Vita C, et al. The pharmacologic therapy of post‐cauterization and post‐laser vaporization with polydeoxyribonucleotide. Ann Ostet Ginecol Med Perinat. 1990; 111(6): 372‐ 378. PubMed PMID: 2102064 2102064
  15. [16]Muratore O, Pesce Schito A, Cattarini G, et al. Evaluation of the trophic effect of human placental polydeoxyribonucleotide on human knee skin fibroblasts in primary culture. Cell Mol Life Sci. 1997; 53(3): 279‐ 285. doi: 10.1007/pl00000605 9104493 PMC11147285 · DOI
  16. [17]Thellung S, Florio T, Maragliano A, Cattarini G, Schettini G. Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes. Life Sci. 1999; 64(18): 1661‐ 1674. doi: 10.1016/s0024-3205(99)00104-6 10328526 · DOI · Paper page
  17. [18]Valdatta L, Thione A, Mortarino C, Buoro M, Tuinder S. Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study. Curr Med Res Opin. 2004; 20(3): 403‐ 408. doi: 10.1185/030079904125003116 15025849 · DOI · Paper page
  18. [20]Kim DS, Lee JK, Kim JH, et al. Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs. Sci Adv. 2021; 7(50): eabj1083. Epub 20211208. doi: 10.1126/sciadv.abj1083 34878837 PMC8654289 · DOI
  19. [21]Guizzardi S, Galli C, Govoni P, et al. Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: a new proposal for bone tissue repair. Life Sci. 2003; 73(15): 1973‐ 1983. doi: 10.1016/s0024-3205(03)00547-2 12899922 · DOI · Paper page
  20. [22]Altavilla D, Bitto A, Polito F, et al. Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers. Cardiovasc Hematol Agents Med Chem. 2009; 7(4): 313‐ 321. doi: 10.2174/187152509789541909 19860658 · DOI · Paper page
  21. [23]Galeano M, Bitto A, Altavilla D, et al. Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse. Wound Repair Regen. 2008; 16(2): 208‐ 217. doi: 10.1111/j.1524-475X.2008.00361.x 18318806 · DOI
  22. [24]Belletti S, Uggeri J, Gatti R, Govoni P, Guizzardi S. Polydeoxyribonucleotide promotes cyclobutane pyrimidine dimer repair in UVB‐exposed dermal fibroblasts. Photodermatol Photoimmunol Photomed. 2007; 23(6): 242‐ 249. doi: 10.1111/j.1600-0781.2007.00320.x 17986061 · DOI · Paper page
  23. [25]Kim YJ, Kim MJ, Kweon DK, Lim ST, Lee SJ. Polydeoxyribonucleotide activates mitochondrial biogenesis but reduces MMP‐1 activity and melanin biosynthesis in cultured skin cells. Appl Biochem Biotechnol. 2020; 191(2): 540‐ 554. Epub 20191207. doi: 10.1007/s12010-019-03171-2 31811642 · DOI · Paper page
  24. [26]Noh TK, Chung BY, Kim SY, et al. Novel anti‐melanogenesis properties of polydeoxyribonucleotide, a popular wound healing booster. Int J Mol Sci. 2016; 17(9): 1448. Epub 20160901. doi: 10.3390/ijms17091448 27598132 PMC5037727 · DOI · Paper page
  25. [27]Lee SH, Yoo SH, Lee HJ, et al. Anti‐allodynic effects of polydeoxyribonucleotide in an animal model of neuropathic pain and complex regional pain syndrome. J Korean Med Sci. 2020; 35(26): e225. Epub 20200706. doi: 10.3346/jkms.2020.35.e225 32627441 PMC7338212 · DOI
  26. [28]Mannino F, Pallio G, Bitto A, et al. Targeting adenosine receptor by polydeoxyribonucleotide: an effective therapeutic strategy to induce white‐to‐brown adipose differentiation and to curb obesity. Pharmaceuticals (Basel). 2021; 14(8): 728. Epub 20210727. doi: 10.3390/ph14080728 34451825 PMC8402160 · DOI
  27. [29]Park KY, Seok J, Rho NK, Kim BJ, Kim MN. Long‐chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients. Dermatol Ther. 2016; 29(1): 37‐ 40. Epub 20151102. doi: 10.1111/dth.12299 26814448 · DOI · Paper page
  28. [30]Kim JH, Jeong JJ, Lee YI, et al. Preventive effect of polynucleotide on post‐thyroidectomy scars: a randomized, double‐blinded, controlled trial. Lasers Surg Med. 2018: 755‐ 762. Epub 20180325. doi: 10.1002/lsm.22812 29574803 · DOI · Paper page
  29. [31]Lee YJ, Kim HT, Lee YJ, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double‐blind, split‐face trial. J Dermatolog Treat. 2022; 33(1): 254‐ 260. Epub 20200406. doi: 10.1080/09546634.2020.1748857 32248707 · DOI
  30. [32]Kim MJ, Park HJ, Oh SM, Yi KH. Polynucleotide injection treatment for iatrogenic fat atrophy in two patients: potential for safe volumization in aesthetic medicine. Skin Res Technol. 2023; 29(8): e13439. doi: 10.1111/srt.13439 37632185 PMC10423761 · DOI · Paper page
  31. [33]Lee D, Kim MJ, Park HJ, et al. Current practices and perceived effectiveness of polynucleotides for treatment of facial erythema by cosmetic physicians. Skin Res Technol. 2023; 29(9): e13466. doi: 10.1111/srt.13466 37753681 PMC10485387 · DOI
  32. [34]Alves R, Grimalt R. A review of platelet‐rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord. 2018; 4(1): 18‐ 24. Epub 20170706. doi: 10.1159/000477353 29457008 PMC5806188 · DOI
  33. [35]Garraud O, Tariket S, Sut C, et al. Transfusion as an inflammation hit: knowns and unknowns. Front Immunol. 2016; 7: 534. Epub 20161129. doi: 10.3389/fimmu.2016.00534 27965664 PMC5126107 · DOI
  34. [36]Lin MY, Lin CS, Hu S, Chung WH. Progress in the use of platelet‐rich plasma in aesthetic and medical dermatology. J Clin Aesthet Dermatol. 2020; 13(8): 28‐ 35. Epub 20200801. PubMed PMID: 33178379; PubMed Central PMCID: PMC7595356 PMC7595356 33178379
  35. [37]Nanda S, Chauhan K, Shetty V, Dashore S, Bhatia S. Platelet‐rich plasma in aesthetics. Indian Dermatol Online J. 2021; 12(Suppl 1): S41‐ S54. Epub 20211125. doi: 10.4103/idoj.idoj_290_21 34976880 PMC8664171 · DOI
  36. [38]Knighton DR, Hunt TK, Thakral KK, Goodson WH, 3rd. Role of platelets and fibrin in the healing sequence: an in vivo study of angiogenesis and collagen synthesis. Ann Surg. 1982; 196(4): 379‐ 388. doi: 10.1097/00000658-198210000-00001 6181748 PMC1352693 · DOI
  37. [39]Kawazoe T, Kim HH. Tissue augmentation by white blood cell‐containing platelet‐rich plasma. Cell Transplant. 2012; 21(2‐3): 601‐ 607. doi: 10.3727/096368911x605538 22793069 · DOI
  38. [40]Cameli N, Mariano M, Cordone I, Abril E, Masi S, Foddai ML. Autologous pure platelet‐rich plasma dermal injections for facial skin rejuvenation: clinical, instrumental, and flow cytometry assessment. Dermatol Surg. 2017; 43(6): 826‐ 835. doi: 10.1097/dss.0000000000001083 28375975 · DOI
  39. [41]Alam M, Hughart R, Champlain A, et al. Effect of platelet‐rich plasma injection for rejuvenation of photoaged facial skin: a Randomized Clinical Trial. JAMA Dermatol. 2018; 154(12): 1447‐ 1452. doi: 10.1001/jamadermatol.2018.3977 30419125 PMC6583756 · DOI
  40. [42]Abuaf OK, Yildiz H, Baloglu H, Bilgili ME, Simsek HA, Dogan B. Histologic evidence of new collagen formulation using platelet rich plasma in skin rejuvenation: a prospective controlled clinical study. Ann Dermatol. 2016; 28(6): 718‐ 724. Epub 20161123. doi: 10.5021/ad.2016.28.6.718 27904271 PMC5125953 · DOI
  41. [43]Kim DH, Je YJ, Kim CD, et al. Can platelet‐rich plasma be used for skin rejuvenation? Evaluation of effects of platelet‐rich plasma on human dermal fibroblast. Ann Dermatol. 2011; 23(4): 424‐ 431. Epub 20111103. doi: 10.5021/ad.2011.23.4.424 22148008 PMC3229934 · DOI
  42. [44]Hofny ERM, Abdel‐Motaleb AA, Ghazally A, Ahmed AM, Hussein MRA. Platelet‐rich plasma is a useful therapeutic option in melasma. J Dermatolog Treat. 2019; 30(4): 396‐ 401. Epub 20181129. doi: 10.1080/09546634.2018.1524821 30220226 · DOI
  43. [46]Merchan WH, Gomez LA, Chasoy ME, Alfonso‐Rodriguez CA, Munoz AL. Platelet‐rich plasma, a powerful tool in dermatology. J Tissue Eng Regen Med. 2019; 13(5): 892‐ 901. Epub 20190409. doi: 10.1002/term.2832 30793521 · DOI
  44. [47]Barrientos S, Brem H, Stojadinovic O, Tomic‐Canic M. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen. 2014; 22(5): 569‐ 578. doi: 10.1111/wrr.12205 24942811 PMC4812574 · DOI
  45. [48]Yun WJ, Bang SH, Min KH, Kim SW, Lee MW, Chang SE. Epidermal growth factor and epidermal growth factor signaling attenuate laser‐induced melanogenesis. Dermatol Surg. 2013; 39(12): 1903‐ 1911. Epub 20131017. doi: 10.1111/dsu.12348 24131350 · DOI
  46. [49]Lyons A, Stoll J, Moy R. A randomized, double‐blind, placebo‐controlled, split‐face study of the efficacy of topical epidermal growth factor for the treatment of melasma. J Drugs Dermatol. 2018; 17(9): 970‐ 973. PubMed PMID: 30235384 30235384
  47. [50]Choi J‐K, Chung H, Oh SJ, Kim J‐W, Kim S‐H. Functionally enhanced cell spheroids for stem cell therapy: Role of TIMP1 in the survival and therapeutic effectiveness of stem cell spheroids. Acta Biomaterialia 2023; 166: 454‐ 469. 10.1016/j.actbio.2023.05.033 37230438 · DOI
  48. [51]Zhang B, Gong J, He L, Khan A, Xiong T, Shen H, et al. Exosomes based advancements for application in medical aesthetics. Front Bioeng Biotechnol. 2022; 10: 1083640. Epub 20221220. doi: 10.3389/fbioe.2022.1083640 36605254 PMC9810265 · DOI
  49. [52]Olumesi KR, Goldberg DJ. A review of exosomes and their application in cutaneous medical aesthetics. J Cosmet Dermatol. 2023; 22(10): 2628‐ 2634. Epub 20230727. doi: 10.1111/jocd.15930 37498301 · DOI
  50. [53]Li KJ, Zhou PJ, Guo YN, et al. Recent advances in exosomal non‐coding RNA‐based therapeutic approaches for photoaging. Skin Res Technol. 2023; 29: e13463. doi: 10.1111/srt.13463 37753673 PMC10495620 · DOI
  51. [54]Yi K‐H, Park M‐S, Ree Y‐S, Kim HM. A review on “Skin Boosters”: hyaluronic acid, poly‐L‐lactic acid and pol‐D‐lactic acid, polydeoxyribonucleotide, polynucleotides, growth factor, and exosome. Aesthet. 2023; 4(1): 6. Epub 2023/04/30. doi: 10.46738/Aesthetics.2023.4.1.2 · DOI
  52. [55]Wu JY, Wu SN, Zhang LP, et al. Stem cell‐derived exosomes: a new method for reversing skin aging. Tissue Eng Regen Med. 2022; 19(5): 961‐ 968. Epub 20220709. doi: 10.1007/s13770-022-00461-5 35809187 PMC9477989 · DOI
  53. [56]Yang GH, Lee YB, Kang D, et al. Overcome the barriers of the skin: exosome therapy. Biomater Res. 2021; 25(1): 22. Epub 20210703. doi: 10.1186/s40824-021-00224-8 34217362 PMC8254055 · DOI
  54. [57]Xiong M, Zhang Q, Hu W, et al. The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacol Res. 2021; 166: 105490. Epub 20210212. doi: 10.1016/j.phrs.2021.105490 33582246 · DOI
  55. [58]Liu Y, Wang H, Wang J. Exosomes as a novel pathway for regulating development and diseases of the skin. Biomed Rep. 2018; 8(3): 207‐ 214. Epub 20180131. doi: 10.3892/br.2018.1054 29599975 PMC5867470 · DOI
  56. [59]Hong P, Yang H, Wu Y, Li K, Tang Z. The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review. Stem Cell Res Ther. 2019; 10(1): 242. Epub 20190807. doi: 10.1186/s13287-019-1358-y 31391108 PMC6686455 · DOI · Paper page
  57. [60]Vyas KS, Kaufman J, Munavalli GS, Robertson K, Behfar A, Wyles SP. Exosomes: the latest in regenerative aesthetics. Regen Med. 2023; 18(2): 181‐ 194. Epub 20230104. doi: 10.2217/rme-2022-0134 36597716 · DOI
  58. [61]Damayanti RH, Rusdiana T, Wathoni N. Mesenchymal stem cell secretome for dermatology application: a review. Clin Cosmet Investig Dermatol. 2021; 14: 1401‐ 1412. Epub 20211005. doi: 10.2147/ccid.S331044 PMC8502696 34675575 · DOI
  59. [62]Li L, Ngo HTT, Hwang E, et al. Conditioned medium from human adipose‐derived mesenchymal stem cell culture prevents UVB‐induced skin aging in human keratinocytes and dermal fibroblasts. Int J Mol Sci. 2019; 21(1): 49. Epub 20191219. doi: 10.3390/ijms21010049 31861704 PMC6981944 · DOI
  60. [63]Guo S, Wang T, Zhang S, et al. Adipose‐derived stem cell‐conditioned medium protects fibroblasts at different senescent degrees from UVB irradiation damages. Mol Cell Biochem. 2020; 463(1‐2): 67‐ 78. Epub 20191010. doi: 10.1007/s11010-019-03630-8 31602539 · DOI
  61. [64]de Sousa Victor R, Marcelo da Cunha Santos A, Viana de Sousa B, de Araújo Neves G, Navarro de Lima Santana L, Rodrigues Menezes R. A review on Chitosan's uses as biomaterial: tissue engineering, drug delivery systems and cancer treatment. Materials. 2020; 13(21): 4995. 33171898 PMC7664280
  62. [65]Kim Y, Zharkinbekov Z, Raziyeva K, et al. Chitosan‐based biomaterials for tissue regeneration. Pharmaceutics. 2023; 15(3): 807. 36986668 PMC10055885
  63. [66]Nanduri LSY. Chitosan––stem cell interactions. In: Chitosan for Biomaterials III: Structure‐Property Relationships. Springer; 2021: 343‐ 359.
  64. [67]Farhadihosseinabadi B, Zarebkohan A, Eftekhary M, Heiat M, Moosazadeh Moghaddam M, Gholipourmalekabadi M. Crosstalk between chitosan and cell signaling pathways. Cell Mol Life Sci. 2019; 76: 2697‐ 2718. 31030227 PMC11105701
  65. [68]Charoenwongpaiboon T, Supraditaporn K, Klaimon P, et al. Effect of alternan versus chitosan on the biological properties of human mesenchymal stem cells. RSC Adv. 2019; 9(8): 4370‐ 4379. 35520166 PMC9060545
  66. [69]Liu Z, Wang H, Wang Y, et al. The influence of chitosan hydrogel on stem cell engraftment, survival and homing in the ischemic myocardial microenvironment. Biomaterials. 2012; 33(11): 3093‐ 3106. 22265788
  67. [70]Kim JY, Kim SH, Choi MH, Lee SH, Cha M, Park JU. Novel chitosan dermal filler with enhanced moldability and elasticity. Macromol Biosci. 2022; 22(8): 2200081. 35698278
  68. [71]Sun Y, Li Y, Zhang Y, et al. Unparallel improvement patterns of dynamic wrinkles and skin quality after botulinum toxin type A treatment on the upper face. Skin Res Technol. 2023; 29(3): e13309. doi: 10.1111/srt.13309 36973993 PMC10155803 · DOI
  69. [72]Jeon IK, Chang SE, Park GH, Roh MR. Comparison of microneedle fractional radiofrequency therapy with intradermal botulinum toxin a injection for periorbital rejuvenation. Dermatology. 2013; 227(4): 367‐ 372. Epub 20131121. doi: 10.1159/000356162 24280617 · DOI
  70. [73]Kim MJ, Kim JH, Cheon HI, et al. Assessment of skin physiology change and safety after intradermal injections with botulinum toxin: a randomized, double‐blind, placebo‐controlled, split‐face pilot study in rosacea patients with facial erythema. Dermatol Surg. 2019; 45(9): 1155‐ 1162. doi: 10.1097/DSS.0000000000001819 30730346 · DOI · Paper page
  71. [74]Park KY, Hyun MY, Jeong SY, Kim BJ, Kim MN, Hong CK. Botulinum toxin for the treatment of refractory erythema and flushing of rosacea. Dermatology. 2015; 230(4): 299‐ 301. Epub 20150303. doi: 10.1159/000368773 25765295 · DOI
  72. [75]Bloom BS, Payongayong L, Mourin A, Goldberg DJ. Impact of intradermal abobotulinumtoxinA on facial erythema of rosacea. Dermatol Surg. 2015; 41(suppl 1): S9‐ S16. doi: 10.1097/DSS.0000000000000277 25548852 · DOI
  73. [76]Shie JH, Liu HT, Wang YS, Kuo HC. Immunohistochemical evidence suggests repeated intravesical application of botulinum toxin A injections may improve treatment efficacy of interstitial cystitis/bladder pain syndrome. BJU Int. 2013; 111(4): 638‐ 646. Epub 20120903. doi: 10.1111/j.1464-410X.2012.11466.x 22943596 · DOI
  74. [77]Sayed KS, Hegazy R, Gawdat HI, et al. The efficacy of intradermal injections of botulinum toxin in the management of enlarged facial pores and seborrhea: a split face‐controlled study. J Dermatolog Treat. 2021; 32(7): 771‐ 777. Epub 20200103. doi: 10.1080/09546634.2019.1708241 31865815 · DOI
  75. [78]Chang SP, Tsai HH, Chen WY, Lee WR, Chen PL, Tsai TH. The wrinkles soothing effect on the middle and lower face by intradermal injection of botulinum toxin type A. Int J Dermatol. 2008; 47(12): 1287‐ 1294. doi: 10.1111/j.1365-4632.2008.03895.x 19126019 · DOI
  76. [79]Stegemann A, Raker V, Del Rey A, Steinbrink K, Bohm M. Expression of the alpha7 nicotinic acetylcholine receptor is critically required for the antifibrotic effect of PHA‐543613 on skin fibrosis. Neuroendocrinology. 2022; 112(5): 446‐ 456. Epub 20210611. doi: 10.1159/000517772 34120115 · DOI
  77. [80]Arredondo J, Hall LL, Ndoye A, et al. Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine. Lab Invest. 2003; 83(2): 207‐ 225. doi: 10.1097/01.lab.0000053917.46614.12 12594236 · DOI
  78. [81]Yamauchi PS, Lask G, Lowe NJ. Botulinum toxin type A gives adjunctive benefit to periorbital laser resurfacing. J Cosmet Laser Ther. 2004; 6(3): 145‐ 148. doi: 10.1080/14764170410023767 15545098 · DOI
  79. [82]Carruthers J, Carruthers A. The effect of full‐face broadband light treatments alone and in combination with bilateral crow's feet Botulinum toxin type A chemodenervation. Dermatol Surg. 2004; 30(3): 355‐ 366. discussion 66. doi: 10.1111/j.1524-4725.2004.30101.x 15008861 · DOI
  80. [83]Jung JA, Kim BJ, Kim MS, et al. Protective effect of botulinum toxin against ultraviolet‐induced skin pigmentation. Plast Reconstr Surg. 2019; 144(2): 347‐ 356. doi: 10.1097/PRS.0000000000005838 31348342 · DOI
  81. [84]Kandhari R, Kaur I, Sharma D. Mesococktails and mesoproducts in aesthetic dermatology. Dermatol Ther. 2020; 33(6): e14218. Epub 20200910. doi: 10.1111/dth.14218 32827194 · DOI
  82. [85]Kim JE, Hong JY, Lee HJ, Lee SY, Kim HJ. Picosecond‐domain fractional laser treatment over hyaluronic acid fillers: in vivo and clinical studies. Lasers Surg Med. 2020; 52(10): 928‐ 934. Epub 20200429. doi: 10.1002/lsm.23254 32350899 · DOI
  83. [86]Lee JJ, Yi KH, Kim HS, et al. A novel needle‐free microjet drug injector using Er:YAG LASER: A completely new concept of trans‐dermal drug delivery system. Clin Anat. 2022; 35: 682‐ 685. doi: 10.1002/ca.23892 35445437 · DOI
  84. [87]Langevin HM, Churchill DL, Wu J, et al. Evidence of connective tissue involvement in acupuncture. Faseb J. 2002; 16(8): 872‐ 874. Epub 20020410. doi: 10.1096/fj.01-0925fje 11967233 · DOI · Paper page
  85. [88]Langevin HM, Bouffard NA, Badger GJ, Iatridis JC, Howe AK. Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo. Am J Physiol Cell Physiol. 2005; 288(3): C747‐ C756. Epub 20041020. doi: 10.1152/ajpcell.00420.2004 15496476 · DOI
  86. [89]Zhang B, Gong J, He L, Khan A, Xiong T, Shen H, et al. Exosomes based advancements for application in medical aesthetics. Front Bioeng Biotechnol. 2022; 10: 1083640. Epub 20221220. 36605254 PMC9810265

Cited by

Sorted by citations

Authors
Yi, K., Winayanuwattikun, W., Kim, S., Wan, J., Vachatimanont, V., Putri, A. I., Hidajat, I. J., Yogya, Y., & Pamela, R.
Affiliations
  • Yonsei University College of Dentistry (KR)
  • Mahidol University (TH)
  • VS Line Clinic Incheon South Korea
  • Asia‐Pacific Aesthetic Academy Honk Kong Hong Kong
  • iSKY Center Bangkok Thailand
  • Rejuva Clinic Surabaya Indonesia
  • Atma Jaya Catholic University of Indonesia (ID)
  • Padjadjaran University (ID)
  • Dermatology Research Center (US)
Corresponding author
  • Hidajat, Inneke Jane
  • Yogya, Yuri
  • Pamela, Ruri
ORCID
Venue
Skin Research and Technology
Publisher
Wiley
Published
2024-03
Volume
30
Issue
3
Pages
e13627-e13627
ISSN
  • 0909-752X (ISSN-L)
  • 1600-0846
DOI
10.1111/srt.13627
PMC
PMC10938033
OpenAlex
W4392813780
Cited by
74
References
3
Citations by year
2026: 20 · 2025: 40 · 2024: 14
FWCI
30.24
Type
journal article
Language
en
Status
Retracted
Update notices
retraction (2025-11-21)
Open access
Licence
Locations
  • Skin Research and Technology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
hyaluronic acid, skin aging, wrinkle reduction, skin elasticity, dermal fillers, retracted article
MeSH terms
Dermal Fillers, Cosmetic Techniques, Humans, Hyaluronic Acid, Rejuvenation, Skin, Skin Aging

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